Senior Scientist Resume Example Cobalt Biomedicine (A Flagship Pioneering Venture)

SENIOR SCIENTIST

Professional Summary

Hands-on leader currently managing a research team at Cobalt Biomedicine, an series A-funded biotech (was the first employee, inventor on 2 patents). Significant experience in leading collaborative projects between academic labs or between academia and industry. Strong understanding of cell biology and metabolism in the context of several different biological and disease contexts: obesity/diabetes, cancer/immune-oncology, neurodegeneration, cellular differentiation, diabetic retinopathy, lysosomal storage diseases, among others.

Skills

concept, diabetic, experiments, Imaging, interpretation, novel, Physiology, quality control, Research, scientific, Symposium, Teaching, technical training

Work History

December 2016-CurrentSenior Scientist | Cobalt Biomedicine (a Flagship Pioneering venture) | Cambridge, Massachusetts

Team lead for in vitro scientific discovery team for a Series A-stage biotech start-up (founded by Flagship VentureLabs)
Design and conduct in vitro and in vivo experiments to understand efficacy of potential therapeutics in different disease contexts including metabolic disease, cancer/immuno-oncology, among others
Co-inventor on 2 patent applications

April 2016-CurrentContract Science Writer | JetPub Scientific Communications | Boston, MA

Write/edit scientific web content and reviews.

Consultant |

Flagship VentureLabs.
Led design, execution, and analysis of in vitro work to demonstrate proof of concept of a novel therapeutic.
Aided in design, execution, and interpretation of in vivo animal studies conducted at CROs, involving several different disease models.

May 2016-November 2016Postdoctoral Research Fellow | Lab of Dr. Orian Shirihai, Boston Univ. School of Medicine | Boston, MA

Research work focused on how cellular nutrient exposure dictates mitochondrial dynamics and function in the pancreatic beta-cell.
General research interest includes understanding mechanisms of mitochondrial quality control and how these mechanisms change in human disease.

September 2010-May 2016Graduate Research Student | Lab of Orian Shirihai, Boston University School of Medicine | Boston, MA

Thesis work investigated how cellular nutrient exposure dictates mitochondrial dynamics and function in the pancreatic beta-cell.
General research interest includes understanding mechanisms of mitochondrial quality control and how these mechanisms change in human disease.

March 2008-August 2010Undergraduate Research Assistant | Lab of Dr. Sayon Roy, Boston University School of Medicine | Boston, MA

Senior year Work for Distinction thesis investigated high glucose-induced perturbations to mitochondrial morphology and function and the consequences for retinal cell viability related to diabetic retinopathy.

Education

2016Ph.D: Molecular and Translational MedicineBoston University School of Medicine

Thesis: Elucidating the role of mitochondrial fusion, fission, motility, and turnover in the adaptation to nutrient excess in the pancreatic beta-cell. Advisor: Orian Shirihai
Graduate Research Fellowship from National Science Foundation (2010-2016)
Levinsky Fellowship from Boston University School of Medicine, Molecular Medicine Program (2006-2008)
Russek Student Achievement Day – 1st prize recipient, Boston University School of Medicine, Russek Foundation (2015)
Poster Award, Joint IUBMB/MiP Symposium on Mitochondrial Physiology (2014)
Travel Award, American Physiological Society Conference: Physiological Bioenergetics – From Bench to Bedside (2015)

2010B.A.: Biochemistry and Molecular BiologyBoston University, Boston, MA

Publications

Co-inventor on 2 patents. First author on 7 publications and co-author on 10 publications. Complete list available upon request.

Trudeau K.M., Colby A.H., Zeng J., Las G., Feng J.H., Grinstaff M.W., Shirihai O.S. (2016). Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity. Journal of Cell Biology, 214(1):25-34. Forni, M.F., Peloggia, J., Trudeau, K., Shirihai, O., Kowaltowski, A.J. (2015). Murine Mesenchymal Stem Cell Commitment to Differentiation is Regulated by Mitochondrial Dynamics. Stem Cells, doi: 10.1002/stem.2248. Trudeau, K. M., Gottlieb, R. A., & Shirihai, O. S. (2014). Measurement of mitochondrial turnover and life cycle using MitoTimer. Methods in Enzymology, 547, 21-38.
Ferree, A. W.,
Trudeau, K., Zik, E., Benador, I. Y., Twig, G., Gottlieb, R. A., & Shirihai, O. S. (2013). MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy, 9(11), 1887-1896.
Authors contributed equally to the work. Guan, J., Mishra, S., Qiu, Y., Shi, J., Trudeau, K., Las, G., Liesa, M., Shirihai, O.S., Connors, L.H., Seldin, D.C., Falk, R.H., MacRae, C.A., Liao, R. (2014). Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Molecular Medicine, 6(11), 1493-507. Lovy, A., Molina, A. J. A., Cerqueira, F. M., Trudeau, K., & Shirihai, O. S. (2012). A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy. Journal of Visualized Experiments. Trudeau, K., Muto, T., & Roy, S. (2012). Downregulation of mitochondrial connexin 43 by high glucose triggers mitochondrial shape change and cytochrome c release in retinal endothelial cells. Investigative Ophthalmology and Visual Science, 53(10), 6675-6681. Roy, S., Trudeau, K., Roy, S., Tien, T., & Barrette, K. F. (2013). Mitochondrial dysfunction and endoplasmic reticulum stress in diabetic retinopathy: mechanistic insights into high glucose-induced retinal cell death. Current Clinical Pharmacology, 8(4), 278-284. Trudeau, K., Molina, A. J. A., & Roy, S. (2011). High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Investigative Ophthalmology and Visual Science, 52(12), 8657-64. Trudeau, K., Roy, S., Guo, W., Hernández, C., Villarroel, M., Simó, R., & Roy, S. (2011). Fenofibric acid reduces fibronectin and collagen type IV overexpression in human retinal pigment epithelial cells grown in conditions mimicking the diabetic milieu: Functional implications in retinal permeability. Investigative Ophthalmology and Visual Science, 52(9), 6348-6354. Chronopoulos, A., Trudeau, K., Roy, S., Huang, H., Vinores, S. A., & Roy, S. (2011). High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: implications for diabetic retinopathy. Current Eye Research, 36(8), 747-753. Trudeau, K., Molina, A. J. A., Guo, W., & Roy, S. (2010). High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. The American Journal of Pathology, 177(1), 447-455. Bobbie, M. W., Roy, S., Trudeau, K., Munger, S. J., Simon, A. M., & Roy, S. (2010). Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice. Investigative Ophthalmology and Visual Science, 51(7), 3758-3763. Roy, S., Ha, J., Trudeau, K., & Beglova, E. (2010). Vascular basement membrane thickening in diabetic retinopathy. Current Eye Research, 35(12), 1045-1056. Roy, S., Trudeau, K., Behl, Y., Dhar, S., & Chronopoulos, A. (2010). New insights into hyperglycemia-induced molecular changes in microvascular cells. Journal of Dental Research, 89(2), 116-127.

Presentations

Presented research work >8 times at various conferences, both domestic and international. Can provide a complete list upon request.

Resume Overview

Companies Worked For:

Cobalt Biomedicine (a Flagship Pioneering venture)
JetPub Scientific Communications
Lab of Dr. Orian Shirihai, Boston Univ. School of Medicine
Lab of Orian Shirihai, Boston University School of Medicine
Lab of Dr. Sayon Roy, Boston University School of Medicine

School Attended

Boston University School of Medicine
Boston University

Job Titles Held:

Senior Scientist
Contract Science Writer
Consultant
Postdoctoral Research Fellow
Graduate Research Student
Undergraduate Research Assistant

Degrees

Ph.D : Molecular and Translational Medicine
B.A. : Biochemistry and Molecular Biology

Senior Scientist Resume Example

Resume Score: 60%

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