Creative, highly-motivated researcher with 16 years of experience in basic research in top research institutes in the US and France. Long-lasting interest in understanding the mechanisms of immune system functions in development and disease. Excellent research background in immuno-oncology, oncology, inflammation, bone biology and immune tolerance, and in developing cell culture methods and mouse models to study human disease. Extensive experience in molecular biology, including RNAi, immunomonitoring and imaging techniques.
Successful in developing research objectives and strategies. Proven ability to coordinate a group of scientists from different disciplines. Successful in networking and collaborating with international partner institutions. Experienced in writing grant proposals and manuscripts, and budget managing. Excellent publication record. Frequent participation in conferences and workshops. Eager to take over new jobs and responsibilities, to test new limits and contribute to ground-breaking research.
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Managing the maternal/fetal tolerance project
Supervising a PhD student and coordination of national and international collaborators
Developing a comparative method to identify common mechanisms in tumor grow and pregnancy
Establishing novel research methods to study immune tolerance in pregnancy
Identification of a distinct regulatory T cell population in the uterus and its relationship to mast cells
Experience in clinical trials management: French and international regulation, selection, set up, monitoring, closure
Development of methods to study the effects of combinatorial therapies (anti-CTLA-4 and local radiation) to understand immune cell functions during tumor development and regression.
Establishment of in vivo and in vitro cell migration assays and data analysis.
Supervision of undergraduate students.
Establishment of a model to study inflammation-induced bone loss and methods to record and quantify mouse behavior
Expertise in signal transduction cell culture systems and NF-kB signaling
Bone biology and methods to study bone development and diseases
Animal handling
Gene functions and regulation/ AP-1 transcription factor
Molecular and cellular biology
Cell culture
AP-1/Fos-Jun
Florez L, Fourcade L, Nehar-Belaid D, Vasquez T, Courau T, Charlaud G, Beault B, Pumarola-Beatle M , Fondevila MD, Klatzmann D and Ruocco MG. IL-2 independent uterine Tregs produce IL-9 and recruit mastocytes to enforce maternal-fetal tolerance (In preparation)
Nehar-Belaid D, Courau T, Dérian N, Florez L, Ruocco MG and Klatzmann D. Regulatory T cells orchestrate similar immune evasion of fetuses and tumors in mice. J Immunol. 2016 Jan 15;196(2):678-90
Ruocco MG, Chaouat G, Florez L, Bensussan A, Klatzmann D. Regulatory T cells in pregnancy: historical perspective, state of the art and burning questions. Front. Immunol. 2014 Aug 21;5:389. (review)
Ruocco MG, Pilones KA, Kawashima N, Cammer M, Huang J, Babb JS, Liu M, Formenti SC, Dustin ML, Demaria S. Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects.
J Clin Invest. 2012 Oct 1;122(10):3718-30
Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG, Klinakis A, Lukyanov Y, Tseng JC, Sen F, Gehrie E, Li M, Newcomb E, Zavadil J, Meruelo D, Lipp M, Ibrahim S, Efstratiadis A, Zagzag D, Bromberg JS, Dustin ML, Aifantis I. Regulation of leukemic cell CNS infiltration by Notch1-induced CCR7 chemotaxis. Nature. 2009 Jun 18;459(7249):1000-4
Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M., I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005 2005 May16; 201(10):1677-87
2015 DIM BIOTHERAPIES Médecine Régénérative, Cellules souches et Transplantation, Co-financement de Manifestation Scientifique to organize the International Symposium "Materno-fetal tolerance", together with David Klatzmann and Gerard Chaouat
2013 DIM BIOTHERAPIES Médecine Régénérative, Cellules souches et Transplantation, Co-financement de Petits et Moyens Equipements
2013-2016 DIM BIOTHERAPIES Médecine Régénérative, Cellules souches et Transplantation: Allocation Doctorale, Ecole Doctorale Physiologie Physiopathologie
2012-2014 Marie Curie International Incoming Fellowship (IIF)
2009 Young Investigator Travel Award, International Society for Biological Therapy of Cancer
2006-2009 Boehringer Ingelheim Postdoctoral Fellowship
2000 FEBS/EMBO Summer School Fellowship
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