A diversely-skilled pharmacologist with over seven years of work experience in pharmaceutical, biotech and CRO environments. A motivated individual with a logical analytical mindset, ability to digest large datasets, excellent organizational skills and strong work ethic, Skilled in cell HTS screening, assay development and optimization, liquid-handling robotics programming, bioanalysis and in vitro ADME and PK analyses. Enthusiastic learner, eager to tackle new challenges collaboratively and independently, with a passion for innovative research and a track record of delivering on multiple projects to deadlines.
Actively pursing a Senior Research Scientist role with a thriving company in the Bay Area. Legally authorized to work in the US on L2 visa and EAD.
Pharmaceutical Sciences Analytical Research Development Group
Discovery Biology GenitoUrinary Therapeutic Area
Autotaxin is a lysophospholipase D enzyme and the predominant enzyme responsible for production of the bioactive lipid agonist, lysophosphatidic acid. My project demonstrated that this classically secreted protein is found extracellularly as both a soluble and vesicular enzyme, externally bound to an important population of intercellular signaling vesicles named exosomes.
Experiments demonstrated that vesicular ATX is functionally relevant as it catalyses exosomal lysophosphatidylcholine to produce a localized source of the signaling molecule LPA. In this form, ATX can deliver LPA directly to its cognate receptors and initiate downstream growth and motility signaling responses. Further work identified novel linking proteins and explored the mechanism by which ATX associates with them utilizing site-directed mutagenesis and recombinant protein expression approaches.
Received a fully-funded four year studentship from the BBSRC and the Oon Khye Beng Ch'Hia Tsio studentship in preventative medicine from Downing College, University of Cambridge
Jethwa S.A., Leah E.J., Zhang, Q., Bright N.A., Oxley D., Bootman M.D., Rudge S.A. and Wakelam M.J.O.; Exosomes bind autotaxin and act as a physiological delivery mechanism to stimulate LPA receptor signalling in recipient cells. Oct 2016, Journal of Cell Science
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