Multitalented, results-oriented professional with extensive knowledge in: enzymology, molecular/cellular biology, medical research investigation, achieving a PhD in Pharmacy, a patent-holder and author of numerous publications. Possesses the detailed knowledge and expertise necessary to make a significant contribution within the pharmaceutical, drug discovery, biotechnology, and life science industries. Proven track record for effective leadership, fostering consensus building among inter-disciplinary team and managing a broad spectrum of projects and services driving results and creating revenue.
Application of a polysaccharide derived from Ophiopogon japonicas in preparation of food additives, health care products and drugs with antiobesity effect.
PCT/CN2001/074709 2011 2.
Application of one kind of health care products complete sample.
CN 201110021218.1 (China) 2011 3.
Application of extract from Alocasia cucullata in preparation of anti-cervical cancer drug.
CN 201110148300.0 (China) 2011 4.
Application of senkyunolide I in preparation of drugs with antistroke effect and convalescence stage therapy.
CN 201010107765.7 (China) 2010 5.
Application of senkyunolide H in preparation of drugs with antistroke effect.
CN 201010107770.8 (China) 2010 6.
Preparation method of extract from Alocasia cucullata in anticancer drug.
CN 201010608330.0(China) 2010 7.
Application of senkyunolide J in preparation of drugs with antiapoplexy effect.
CN 201010107759.1 (China) 2010 8.
Application of polysaccharide from Ophiopogon japonicas, MDG-1, in preparation of drugs with angiogenesis effect.
CN 200910200667.5 (China) 2009.
University of GeorgiaSeptember 2013 to CurrentAthens, GA
Postdoctoral Research Associate Professor Kelley Moremen's Lab, Complex Carbohydrate Research Center Optimized large-scale expression system with mammalian cells for the recombinant protein expression and expressed/ purified more than 50 proteins for structural and functional studies Collaborations with investigators for NMR, MS, structure and activities resulted in publications in eLife, JBC, Angewandte Chemie Characterization of mammalian glycosylation enzymes with diverse enzyme activity assays to determine the interaction between glycosidases and glycosyltransferases and corresponding substrates.
Queen's UniversityApril 2012 to August 2013Ontario
Postdoctoral Research Associate Professor Inka Brockhausen's Glycobiology Lab, Biomedical/Molecular Sciences Extensive expertise in both native and affinity tagged protein expression and purification using microbial systems Experience in enzyme kinetics, assay development and optimization, enzyme inhibitor design and high throughput screening Hands-on experience on radio/fluorescence/luminescence enzyme activity assay, and developing enzyme activity assay with capillary electrophoresis, HPLC and MS Expressed, purified and characterized two -1,3-Galactosyltransferase from E.
coli and a 1,3-rhamnosyltransferase from P.
aeruginosa and test as targets for the development of antibacterial drug candidates Designed two-step enzymatic synthesis of GDP-D-[3H]Rha for using as substrate in rhamnosyltransferase study.
Shanghai University of Traditional Chinese MedicineJanuary 2009 to January 2012Research Assistant Shanghai, China
Obtained three government research grants as primary investigator and seven funding as co-investigator Supervised and mentored three graduate students to obtain their PhD's Led team of six scientists to study large-scale factory production, quality control, DMPK, bioactivities and mechanism preclinical studies of novel botanic polysaccharide, MDG-1, from Ophiopogon japonicas Applied for PCT patent of MDG-1 in preparation of food additives, health care products and drugs with anti-obesity effect.
Beijing Double-Crane Pharmaceutical Co., LtdJuly 2002 to July 2003Research Scientist Beijing, China
Performed research pharmacology within drug discovery program teams on preclinical studies of immunological, cardiovascular, diabetes and cancer drug candidates Complied with company policies and SOPs.
Shanghai University of Traditional Chinese Medicine1 2009PhDShanghai, ChinaFirst reported cases of a polysaccharide from plant display potential anti-ischemic properties and demonstrated its mechanism
involved in inducing S1P1 expression and augmenting survival and angiogenesis in ischemic heart. Published in Glycobiology
Colleges of Traditional Chinese Medicine of Jiangxi, Nanchang, Jiangxi, China 2006
Shenyang Pharmaceutical University1 2002Master of ScienceShenyang, Liaoning Province, China
Bachelor of Science
1. Shuo Wang, Diana Czuchry, Bin Liu, Anna N. Vinnikova, Yin Gao, Jason Z. Vlahakis, Walter A. Szarek, Lei Wang, Lu Feng, Inka Brockhausen. Characterization of Two UDP-Gal:GalNAc-Diphosphate-Lipid 1,3-Galactosyltransferases WbwC from Escherichia coli Serotypes O104 and O5. Journal of Bacteriology. 2014, 196(17): 31223133. 2. Jeremy L. Praissman, David H. Live, Shuo Wang, Annapoorani Ramiah, Kelley W. Moremen, Lance Wells. B4GAT1 is the Priming Enzyme for the LARGE-dependent Functional Glycosylation of -Dystroglycan. eLife. DOI: 2014;10.7554/eLife.03943. 3. Chen Zhang, You Zhuo, Heather A. Moniz, Shuo Wang, Kelley W. Moremen, James Prestegard, Edward M. Brown. Becker. Direct Determination of Multiple Ligand Interactions on the Extracellular Domain of the Calcium Sensing Receptor. Journal of Biological Chemistry. Accepted. 2014. 4. Anna N. Vinnikova, Tatyana N. Druzhinina, Leonid L. Danilov, Natalia S. Utkina, Vladimir I. Torgov, Vladimir V. Veselovsky, Shuo Wang, Bin Liu, Lei Wang, Inka Brockhausen. The Synthesis of P1-[11-(Anthracen-9- ylmethoxy)undecyl]-P2-(2-acetamido-2-deoxy--D-glucopyranosyl) diphosphate and the Study of Its Acceptor Properties in the Enzymatic Reaction Catalyzed by a D-Rhamnosyltransferase from PSEUDOMONAS AERUGINOSA. Russian Journal of Bioorganic Chemistry. Accepted. 2014. 5. Shuo Wang, Youai Hao, Joseph S Lam, Jason Z Vlahakis, Walter A Szarek, Anna Vinnikova, Ole Hindsgaul, Inka Brockhausen. Biosynthesis of the Common Polysaccharide Antigen of Pseudomonas aeruginosa PAO1: Characterization and role of GDP-D-rhamnose: GlcNAc/GalNAc-diphosphate-lipid 1,3-D-rhamnosyl-transferase WbpZ. Journal of Bacteriology. in press. 6. Claudia Bello, Shuo Wang, Lu Meng, Kelley W. Moremen Christian F. W. Becker. A PEGylated Photocleavable Auxiliary Mediates the Site-Specific Glycosylation and Native Chemical Ligation of Peptides. Angewandte Chemie. in press. 7. Zhixuan Li, Heather A. Moniz, Shuo Wang, Annapoorani Ramiah, Kelley W. Moremen and Joshua S. Sharp. High Structural Resolution Hydroxyl Radical Protein Footprinting Reveals an Extended Robo1-Heparin Binding Interface. Journal of Biological Chemistry. in press. 8. Shuo Wang, Hidenori Tanaka, Ole Hindsgaul, Joseph S. Lam, Inka Brockhausen. A convenient synthesis of GDP-D- rhamnose: the donor substrate for D-rhamnosyltransferase WbpZ from Pseudomonas aeruginosa PAO1. Bioorg. Med. Chem. Lett. 2013, 23(12): 34913495. 9. Anna N. Vinnikova, Tatyana N. Druzhinina, Leonid L. Danilov, Natalia S. Utkina, Vladimir I. Torgov,Vladimir V. Veselovsky, Shuo Wang, Bin Liu, Lei Wang, Inka Brockhausen. Synthesis of a fluorescent acceptor substrate for glycosyltransferases involved in the assembly of O-antigens of enterohemorrhagic Escherichia coli O157 and O5. Carbohydrate Research. 2013, 366: 17-24. 10. Shuo Wang, Xiao Lin, Ling-Yi Wang, Ke-Feng Ruan, Yi Feng, Xiao-Yan Li. A polysaccharide MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression. International Journal of Biological Macromolecules. 2012, 50(3): 734-740. 11. Ling-Yi Wang, Yuan Wang, De-Sheng Xu, Ke-Feng Ruan, Yi Feng, Shuo Wang. MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKay mouse model, Journal of Ethnopharmacology. 2012, 143: 3347354 (Corresponding author) 12. Chun-Yong He, Shuo Wang, YiFeng, ShuangLiang, XiaoLin, De-ShengXu, Ke-FengRuan. Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae). Journal of Ethnopharmacology. 2012, 142: 706713. 13. Jie Xu, Yuan Wang, De-Sheng Xu, Yi Feng, Shuo Wang. Hypoglycemic effects of MDG-1, a polysaccharide derived from Ophiopogon japonicas, in the ob/ob mouse model of type 2 diabetes mellitus, International Journal of Biological Macromolecules, 2011, 49 (4) 657662 (Corresponding author). 14. Xiao Lin, Zhuo-Jun Wang, Shuo Wang, Lan Shen, Yi Feng, De-sheng Xu. Comparison of tissue distribution of a PEGylated Radix Ophiopogonis polysaccharide in mice with normal and ischemic myocardium. European Journal of Pharmaceutics and Biopharmaceutics, 2011, 79: 621-626. 15. Shuo Wang, Zhang Zhang, Xiao Lin, De-Sheng Xu, Yi Feng and Kan Ding. A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart, Glycobiology, 2010, 20(4): 473-484. 16. Xiao Lin, Shuo Wang, Yan Jiang, Zhuo-jun Wang, Gui-lan Sun, De-sheng Xu, Yi Feng, Lan Shen. Poly (ethylene glycol)- Radix Ophiopogonis polysaccharide conjugates: Preparation, characterization, pharmacokinetics and in vitro bioactivity, European Journal of Pharmaceutics and Biopharmaceutics, 2010, 76: 230-237. 17. Zhang Zhang, Shuo Wang, Hong Qiu, Chao-Hui Duan, Zheng-Tao Wang, Kan Ding. WT, a new triterpene from Gentiana waltonii Burkill, induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo, Cancer Letters 2009, 286(2): 223-231. 18. Shuo Wang, Yi Feng, Yuan Wang, De-Sheng Xu. The effect of polysaccharide from Radix astragali on cells survive against oxygen glucose deprivation and phosphorylation of Akt, Chinese Journal of Pharmaceutical Biotechnology, 2011, 18(4): 288-290. 19. Shuo Wang, Yi Feng, Yuan Wang, Shuang Liang, Ling-Yi Wang, De-Sheng Xu. Senkyunolide I promotes endothelial cells angiogenesis through PIGF signaling pathway, Chinese Journal of Pharmaceutical Biotechnology, 2011, 18(3): 211- 214. 20. Ling-Yi Wang, Yuan Wang, Ke-Feng Ruan, Shuo Wang, Yi Feng. Effects of polysaccharide MDG-1 from Ophiopogon japonicus on glucose tolerance and intestinal flora in non-diabetic mice, Chinese Journal of New Drugs and Clinical Remedies, 2011, 6(30): 453-457 (Corresponding author). 21. Shuo Wang, Yi Feng, Kan Ding, Xin-Ping Wang, De-Sheng Xu. Cell protection of polysaccharide from Ophiopogon Japonieus under the condition of oxygen glucose deprivation through S1P1 signaling pathway, Chinese Journal of Pharmaceutical Biotechnology, 2009, 16(3): 220-224. 22. Shuo Wang, Yi Feng, Kan Ding, Xin-Ping Wang, De-Sheng Xu. Effect of Ophiopogon Japonieus polysaccharide MDG-1 on leptin expression in human microvascular endothelial cells, Chinese Journal of Applied Physiology, 2009, 25(2): 160- 161.