My doctoral study on neuro-degenerative disorders namely Parkinson's Disease (PD), Multiple System Atrophy (MSA), and Progressive Supra-nuclear Palsy (PSP) was aimed at developing suitable paradigms to pattern measure the hemo-dynamic response for speech, motor and short term memory loss. The differential BOLD brain activation pattern for the parkinsonian patients, and its significance in differential diagnosis was attempted. The extent of neuro-degeneration was ascertained using voxel based morphometry (VBM), and fiber tractography using diffusion tensor imaging (DTI). The studies repeated after a period of 12 months evaluated the neuronal loss in the concerned brain areas and the effect of dopaminergic therapy and progress of the disease.
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