PhD level biomedical scientist with 15 years of experience with great expertise on initiating, directing and executing scientific research on neuroscience and cardiovascular biology.
*Extensive experience in vitro and in vivo models of neurodegenerative and cardiovascular diseases.
*Hands on experience on tissue cardiac stem cell and fibroblast derivation, characterization and functional assessment.
*Strong publication record in peer-reviewed scientific journals.
Protein Science: Extensive expertise in Western blotting and IP, ELISA, Enzyme Activity Assays
Cell-Based Assays: Excellent tissue/cell culture skills and working with relevant instrumentation such as isolation and maintenance of adult stem cells and fibroblast from cardiovascular tissue. Mammalian and primary cell culture techniques, transfection and lentiviral transduction.
Molecular Biology: -RNA and DNA isolation, PCR, Quantitative PCR, molecular cloning techniques.
Imaging techniques: Immunohistocemistry, Immunofluorescence and Immnunocytochemistry, In-situ hybridization, Fluorescent and Confocal microscopy.
Animal Husbandry: Handling experimental animals: breeding and maintaining the colony of transgenic mice.
Post-doctoral Researcher01/2010 to 01/2015Banner Sun Health Research Institute Dr. Mohamed GaballaSun City, AZ
Initiated and performed research to investigate epigenetic regulation of cardiac fibrosis in heart failure.
Identified class-I histone deacetylases dependent signaling pathways associated with cardiac fibrosis by executing in vivo and in vitro experiments.
Developed and performed isolation and culture of cardiac fibroblasts from adult cardiovascular tissue.
Isolated subpopulation of cardiac fibroblast based on cell surface markers.
Investigated molecular factors involved in regulation of cardiac stem cell biology.
Contributed to discovery of beneficial effects of cardiac stem cells in regeneration and cardiac repair in heart failure.
Led a project to investigate structural and functional changes occur in brain due to myocardial infarction.
Supervised and trained research associates and interns.
Performed independent planning and execution of projects, data analysis and manuscript and grant proposal writing.
Served as reviewer to manuscripts submitted to peer-reviewed journals.
07/2009 to 07/2010
PI (Hikmet Nural), Arizona Alzheimer's Disease Core Center pilot Grant, 5 P30 AG019610-09," Investigation of therapeutic effects of Thalidomide in Alzheimer's disease model".
Post-doctoral Researcher01/2008 to 01/2010Banner Sun Health Research InstituteSun City, AZ
Initiated and involved in development of a specific ELISA to measure BACE1 in human tissues.
Investigated putative biomarkers for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.
Investigated therapeutic effects of Chinese herbal compounds and Thalidomide in Alzheimer's disease.
Received a pilot grant from Arizona Alzheimer's Disease Core Center.
Doctoral Researcher01/2000 to 01/2006University of Nevada, Reno Dr. Grant Mastick
Dissertation Title: "Mechanisms of pioneer longitudinal axon guidance in developing mouse brain".
Initiated projects to map projection of early longitudinal axon tracts in mouse embryonic forebrain.
Characterized role of transcription factor Pax6 in projection of forebrain tracts.
Investigated function of Slit/Robo axon guidance cues in initial tract formation in developing mouse brain.
Ph.D: Biochemistry2006University of NevadaRenoBiochemistry
B.Sc: Biology2000Middle East Technical UniversityTurkeyBiology
Department of Biochemistry
Farmer WT, Altick AL, Nural HF, Dugan JP, Kidd T, Charron F, and Mastick GS.
Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals." Development 2008 135:3643-3653.
Nural HF, Farmer WT and Mastick GS "The Slit receptor Robo1 is predominantly expressed via the Dutt1 alternative promoter in pioneer neurons in the embryonic mouse brain and spinal cord" Gene Expr Patterns.
2007 October; 7(8): 837-845.
Nural HF and Mastick GS "Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain" J Comp Neurol.
2004 Nov 22; 479(4):399-409.
PHS 398/2590 (Rev.
09/04) Page Biographical Sketch Format Page.
Zakharova L, Nural-Guvener HF, Feehery L, Popovic S, Gaballa MA. Transplantation of epigenetically modified adult cardiac c-Kit cells retards remodeling and improves cardiac function in ischemic heart failure model. Stem Cell Translational Medicine in press Nural-Guvener HF, Zakharova L, Feehery L, Popovic S, Gaballa MA. Anti-fibrotic effects of Class I HDAC inhibitor, Mocetinostat is associated with IL-6/Stat3 signaling in ischemic heart failure. Int J Mol Sci. 2015 May 19;16 (5):11482-99. Nural-Guvener HF, Zakharova L, Nimlos J, Popovic S, Mastroeni D, Gaballa MA. HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90 cardiac myofibroblast activation. Fibrogenesis Tissue Repair. 2014 Jul 2; 7:10 Zakharova L, Nural-Guvener H, Feehery L, Popovic S, Nimlos J, Gaballa MA. Retrograde coronary vein infusion of cardiac explant-derived c-Kit cells improves function in ischemic heart failure. J Heart Lung Transplant. 2014 Jun;33(6):644-53 Zakharova L, Nural-Guvener H, Nimlos J, Popovic S, Gaballa MA. Chronic heart failure is associated with transforming growth factor beta-dependent yield and functional decline in atrial explant-derived c-Kit cells. J Am Heart Assoc. 2013 Oct 2; 2(5):e000317. Nural-Guvener HF, Mutlu N, Gaballa MA. BACE1 levels are elevated in congestive heart failure. Neurosci Lett. 2013 Jan 4; 532:7-11 Zakharova L, Nural HF ,Gaballa MA Cardiac explant-derived c-Kit cells are regulated by Notch-modulated mesenchymal transition. PLoS One. 2012; 7(5):e37800 Ewers M, Cheng X, Zhong Z, Nural HF, Walsh C, Meindl T, Teipel SJ, Buerger K, He P, Shen Y, Hampel H.Increased CSF-BACE1 Activity Associated with Decreased Hippocampus Volume in Alzheimer's Disease.J Alzheimers Dis. 2011:25(2):373-81 Gonzales A, Decourt B, Walker A, Condjella R, Nural H, Sabbagh MN. Development of a specific ELISA to measure BACE1 levels in human tissues. J Neurosci Methods. 2011 Oct 30; 202(1):70-6. Rica�o-Cornejo I, Altick AL, Garc�a-Pe�a CM, Nural HF, Echevarr�a D, Miquelaj�uregui A, Mastick GS, Varela-Echavarr�a A. Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain. J Neurosci Res. 2011 Mastick GS, Farmer WT, Altick AL, Nural HF, Dugan JP, Kidd T, Charron F.Longitudinal axons are guided by Slit/Robo signals from the floor plate.Cell Adh Migr. 2010 Jul-Sep; 4(3):337-41. Nural H, Zhong Z, He P, Civarella G, Beach T, Sue L, Adler C, Shill H, Caviness J, Xia W, Shen Y. Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients. Mol Neurodegener. 2009 Jul 15; 4:30. Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA.Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19 (1):264-74. Epub 2008 Oct 25.
biology, cell culture techniques, cell culture, Chinese, data analysis, DNA, ELISA, experiments, functional, grant proposal, Imaging, IP, Molecular Biology, PCR, research, transcription, Western blotting
American Heart Foundation Travel Award 2013
Outstanding Graduating Student, Biochemistry Department, University of Nevada, Reno 2006
Graduate Student Association Research Grant Award, University of Nevada, Reno 2002
Resumes, and other information uploaded or provided by the user, are considered User Content governed by our Terms & Conditions. As such, it is not owned by us, and it is the user who retains ownership over such content.
Companies Worked For:
Banner Sun Health Research Institute Dr. Mohamed Gaballa
Banner Sun Health Research Institute
University of Nevada, Reno Dr. Grant Mastick
Department of Biochemistry
University of Nevada
Middle East Technical University
Job Titles Held:
Ph.D : Biochemistry 2006 B.Sc : Biology 2000
Create a job alert for [job role title] at [location].