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Investigator II Principal Scientist Resume Example

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INVESTIGATOR II PRINCIPAL SCIENTIST
Professional Summary
A motivated analytical and bioanalytical chemist with more than 20 years of experience in the pharmaceutical industry. Started in Ciba-Geigy (now Novartis) in the Analytical Research and Development department (ARD) where I was responsible for method development and validation of HPLC methods, dissolution methods and many other methodologies used for the analysis of formulated drug products, reference standard, active ingredients in accordance to GMP regulations. I joined Novartis, DMPK bioanalytical group, where I supported pre-clinical and clinical studies following GLP and GCP regulations, validated LC-MS/MS methods and provided project support by efficiently communicating scientific results to project teams.
Skills
    Watson LIMS for data storage, study design, analysis and PK calculations Electronic Laboratory Notebook for data recording. Microsoft Excel for data calculations and Microsoft word for reports writing
  • Staff supervision
  • Conference presentation
  • Graduate advising
  • Curriculum development
  • Staff supervision
Work History
January 2011-Current Investigator II Principal Scientist | NOVARTIS PHARMACEUTICALS CORP | East Hanover, NJ
  • Drug Metabolism and Pharmacokinetics, Early Bioanalytical Technologies (EBT).
  • Developed, optimized and validated quantitative LC/MS/MS assays for both small and large molecules in biological matrices in compliance with appropriate SOPs, GLP and GCP guidelines.
  • Analyzed samples from GLP and clinical studies, wrote TK and Bioanalytical data Reports.
  • Over 15 years of experience managing all aspects of clinical studies in Watson data base, clinical Bionalytical report writing and clinical samples reconciliation.
  • Responsible for bioanalytical study outsourcing and provided scientific guidance to Contract Laboratories to ensure a smooth method transfer.
  • Maintained instruments and performed troubleshooting.
  • Operated Applied Biosystem Sciex API4000, API5500, API6500 and Thermo mass spectrometers.
  • Implemented the tissue homogenation process, resulting in high tissues homogenation output, and reduced time spent at the bench.
  • A savings of $500 for each 100 tissues processed was successfully achieved.
  • Introduced and implemented innovative technologies such as the MITRA and it is used in PK/PD critical studies.
  • A saving of at least $10,000 was obtained per study.
  • Worked with Clinical Trial Leaders (CTL) and provided protocol inputs for clinical studies.
  • Mentored and trained new employees.
January 2002-January 2011 Senior Scientist | NOVARTIS PHARMACEUTICALS CORP | East Hanover, NJ
  • Drug Metabolism and Pharmacokinetics, Early Research Support, eBAPK.
  • Developed bioanalytical methods to quantitative analysis of small molecules in biological matrices (blood, plasma, lung, brain, liver, kidney, SMG, CSF and urine) to support aggressive drug discovery programs, provided PK interpretations and wrote PK/PD reports.
  • Performed protein binding experiment using filtration and ultracentrifugation.
January 1997-January 2002 Scientist II and Scientist III | NOVARTIS PHARMACEUTICALS CORP | East Hanover, NJ
  • Drug Metabolism and Pharmacokinetics.
  • Developed bioanalytical methods to quantify small molecular weight compounds in biological matrices for clinical, preclinical and toxicokinetic studies.
  • Used automation for sample processing (e.g., Tomtec Quadra 96 and the Gilson aspec for solid phase, protein precipitation and liquid/liquid extractions.).
  • Analyzed pharmaceutical compounds using the Laser Diode Thermal Desorption ion sourse and the Paper Spray Ion source coupled to a mass spectrometer.
  • Performed studies under GLP regulations.
  • Wrote method validation, bionalytical data and toxicokinetic reports.
January 1989-January 1996 Junior Research Assistant, Associate Scientist I, Associate Scientist II, Scientist I and Scientist II | CIBA-GEIGY Corp NOVARTIS ARD | East Hanover, NJ
  • Extensive experience with HPLC method development, method validation, problem solving, method improvement and chiral separations.
  • Analyzed active ingredients and reference standards to assure their purity using the following instrumentations
Education
BS of Science: Chemistry State University of New York Albany
AS of Applied Science: Agriculture Science State University of NY at Cobleskill AS Agriculture Science
Publications
L. Ramos, R. Bakhtiar, and F. Tse; Application of Liquid Chromatography Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry in the Quantitative Analysis of Glyburide in Human Plasma. Rapid Commun. Mass Spectrom. 13, 2439-2443 (1999) L. Ramos, R. Bakhtiar, T. Majundar, M. Hayes and F. Tse; Liquid chromatography /Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry Enantiomeric Separation of dl-threo-Methylphenidate, (Ritalin ®) Using a Macrocyclic Antibiotic as the Chiral Selector. Rapid Commun. Mass Spectrom. 13, 2054-2062 (1999) L. Ramos, R. Bakhtiar and F. Tse; Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma. Rapid Commun Mass Spectrom.14, 740-745 (2000) L.Ramos, N. Brignol, R. Bakhtiar, L. Mc.Mahon and F.L. Tse; High-throughput approaches to the quantitative analysis of Ketoconazole, a potent hinhibitor of cytochrome p450 3A4, in human plasma. Rapid Commun. Mass Spectrom. 14, 2282-2293 (2000) R. Bakhtiar, J. Lohne, L. Ramos, L. Khemani, M. Hayes, F. Tse; High-throughput quantification of the anti-leukemia drug STI571(GleevecTM) and its main metabolite (CGP74588) in human plasma using liquid chromatography-tandem mass spectrometry, Journal of Chromatography B, 768, 325-340 (2002) L. Ramos, R. Bakhtiar and F. Tse; Quantification of methylphenidate in rat, rabbit and dog plasma using a chiral liquid-chromatography/tandem mass spectrometry method Application to toxicokinetic studies, Analytical Chemica Acta 469, 261-272 (2002) Ray Bakhtiar, Luis Ramos and Francis L. S. Tse; Toxicokinetic assessment of methylphenidate (Ritalin®) in a 13-week oral toxicity study in dogs. Biomedical Chromatography, 18: 45-50 (2004) Ronald E Esser, Rocca Miserendino-Molteni, Michele Sharr,Xiaoli Zhang, Wilma Porter, Luis Ramos, Jeffrey A Cramer, Shumin Zhuang, Anna Georgieva, Wieslawa Maniara; Pharmacodynamic behavior of the selective cyclooxygenase-2 inhibitor Lumiracoxib in the lipopolychaccharide-stimulated rat air pouch model. European Journal of Pharmaceutical Sciences, 25: 25-30 (2005) Xiaohui Chen, Panos Hatsis, Joyce Judge, Upendra A Argikar, Xiaojun Ren, Jason Sarber, Keith Mansfield, Guiqing Liang, Adam Amaral, Alexandre Catoire, Adam Bentley, Luis Ramos, Paul Moench, Samuel Hintermann, David Carcache, Jim Glick, Jimmy Flarako Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry. Anal. Chem. 2016 Dec 16:88(23):11813-11820. Epub 2016 Nov 16.
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Resume Overview

Companies Worked For:

  • NOVARTIS PHARMACEUTICALS CORP
  • CIBA-GEIGY Corp NOVARTIS ARD

School Attended

  • State University of New York
  • State University of NY at Cobleskill

Job Titles Held:

  • Investigator II Principal Scientist
  • Senior Scientist
  • Scientist II and Scientist III
  • Junior Research Assistant, Associate Scientist I, Associate Scientist II, Scientist I and Scientist II

Degrees

  • BS of Science : Chemistry
    AS of Applied Science : Agriculture Science

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