Senior Associate Scientist Resume Example Amgen Inc, Dept. Of Clinical Biomarkers & Diagnostics

SENIOR ASSOCIATE SCIENTIST

Professional Summary

Dedicated Senior Associate Scientist with 16+ years of experience in the biotechnology industry.

Skills

Next-Generation Sequencing

Gene Expression Profiling

Copy Number Variation

PCR Techniques

Nucleic Acid Purification

Sterile / Aseptic Technique

Protein Purification

Western Blotting

Author Analytical Methods

Multitasking

Work History

Senior Associate Scientist, 03/2011 to Current
Amgen Inc, Dept. of Clinical Biomarkers & Diagnostics – Thousand Oaks, CA

Tasked with performing next-generation sequencing, expression profiling, copy number variation and comparative genomic hybridization, providing quality and timely data that informed Amgen's Clinical Biomarker studies.
Collaborate with groups in multiple therapeutic areas to help advance the Amgen pipeline.
Responsible for evaluating and optimizing new technologies, kits, panels and formulations of reagents to develop solutions that current technologies alone do not explore.
Perform validation experiments and author analytical methods for assaying clinical samples. Present methods and supporting data to senior management.
Nucleic acid purification from cells, tissues, FFPE sections, plasma and whole blood.
QC of nucleic acids, libraries and labeled material using qPCR, Agilent Bioanalyzer, Qubit, and spectrophotometer.
Agilent microRNA, expression, and aCGH microarrays.
NanoString nCounter expression, CNV, and RNA-protein assays.
Qualified Ion Torrent PGM & S5, and Illumina MiSeq next-generation sequencing assays for identification of patient stratifying somatic mutations.
Proficient in using internal LIMS systems (SANE, Nautilus, Rainier, PROPS), and Array Studio database for experimental design, sample tracking and to maintain sample chain of custody.

Associate Scientist, 03/2006 to 03/2011
Amgen Inc, Dept. of Molecular Sciences – Thousand Oaks, CA

Expression analysis using array based technologies to support Amgen project and research teams: Affymetrix GeneChip, Agilent microRNA and expression.
Evaluation of Illumina DASL and Nanostring nCounter, resulting in early adoption of the Nanostring platform for transcript analysis of FFPE samples to identify potential diagnostic assays.
Illumina BeadArray focused genotyping.
Responsible for Affymetrix data quality control, importation to Rosetta Resolver for analysis, and archiving.
Optimization and implementation of protocols for isolation of RNA from PAXgene Blood RNA collection tubes that enabled more consistent handling at clinical sites and more reproducible array results.
Coordinated studies with university collaborators.
MiRNA platform evaluation: Invitrogen, High Throughput Genomics & Agilent.
Tecan Agilent automated one & two-color microarray labeling, processing hundreds of samples per month.
Served on development team and trained lab personnel to use expression profiling information management systems.

Senior Associate, 09/2002 to 03/2006
Amgen Inc, Dept. of Molecular Sciences – Thousand Oaks, CA

Microarray in support of multiple Research and Development projects.
Evaluation and optimization of new technologies, arrays and kits; providing feedback to vendors in an effort to improve microarray process and products.
Implemented pipeline process for microarray image data extraction and population into Rosetta Resolver database.

Research Associate I, 11/2000 to 09/2002
Amgen Inc, Dept. of Functional Genomics – Thousand Oaks, CA

Amgen microarray expression profiling in support of Discovery Research.
Lab supply management.

Research Assistant, 05/1998 to 10/2000
The University of Arizona, Dept. of Entomology – Tucson, AZ

Consolidated research findings from experiments in immune response of insects that allow for better understanding of how they transmit diseases.
Lab techniques: SDS-PAGE, Western blotting, chromatography, tissue culture.
Created web pages, and maintained lab colony of Manduca sexta.

Education

Bachelor of Science: Molecular and Cellular Biology,2000
The University of Arizona - Tucson, AZ

Master of Science: Biology, In Progress
California State University, Northridge - Northridge, CA

Publications

Katherine Paweletz, Abraham Anderson, Esther Trueblood, Kelly Hensley, Chetan Deshpande, Pani Kiaei, John Rossi, Michael Damore, Robert Loberg, and Gloria Juan, EGFR-BiTE® antibodies connect resident infiltrating T cells with EGFR-expressing cancer cells for redirected target cell lysis in an ex vivo model of human primary tumors, Cancer Immunology, Immunotherapy, CIIM-D-17-00125.

Michael A. Damore, Suzanne K. Coberly, Karen Wakamiya, Scott Webster, Vaishali Tanna, Xiaolei Xu, Ivan Klement, Rosanne Welcher, Panteha Kiaei, Yi Liu, Kimberly Samayoa, Susan Wong, Lisa Shamon-Taylor, Gregory R. Friberg, John S. Hill, Scott D. Patterson, An EGFRvIII-specific IHC IUO test for patient selection in AMG 595 phase I trial, Journal of Clinical Oncology 31, no. 15_suppl (May 2013) 2071-2071.
Suzanne Coberly; Kimberly Samayoa; Yi Liu; Panteha Kiaei; John Hill; Scott Patterson; Michael Damore, Intertumoral heterogeneity of EGFRvIII expression in glioblastoma multiforme and potential implications for the AMG 595 PHASE 1 Clinical Trial, Neuro-Oncology. 15(suppl_3):iii156–iii164, Nov 2013.
Michael Boedigheimer, Daniel J. Freeman, Michael A. Damore, Panteha Kiaei, Robert Radinsky, Gene Expression Profiles Can Predict Panitumumab Monotherapy Responsiveness in Human Tumor Xenograft Models, Neoplasia (2013) 15, pp. 125-132.

Shalhoub, V., Shatzen, E., Ward, S., Young, J.-I., Boedigheimer, M., Twehues, L., McNinch, J., Scully, S., Twomey, B., Baker, D., Kiaei, P., Damore, M., Pan, Z., Haas, K. and Martin, D. (2010), Chondro/osteoblastic and cardiovascular gene modulation in human artery smooth muscle cells that calcify in the presence of phosphate and calcitriol or paricalcitol. Journal of Cellular Biochemistry, 2010 Nov 1; 111(4): 911–921.

V Shalhoub, E Shatzen, SC Ward, J-I Young, M Boedigheimer, L Twehues, M Damore, P Kiaei, D Fitzpatrick, C Henley, K Haas, D Lacey, and D Martin, Effects of Calcitriol and Paricalcitol on Gene Expression Patterns in Human Coronary Artery Smooth Muscle Cells, Nephrology Dialysis Transplantation, 2006 Jul 1; 21: 410.
V Shalhoub, E Shatzen, C Henley, M Boedigheimer, J McNinch, R Manoukian, M Damore, D Fitzpatrick, K Haas, B Twomey, P Kiaei, S Ward, DL Lacey, D Martin, Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols, Calcified Tissue International, 2006 Dec 1, 79 (6): pp. 431-442.

Pani Kiaei, Lisa Kivman, Frank Asuncion, Maria Gaytan, Maribel Alvarez, Oliver Badali, Linda Esmaili, Jennifer Nnoli, Cathy Coyle-Thompson, Steven B. Oppenheimer, HPLC Isolation of Putative Sea Urchin Cell Adhesion Molecules, Center for Cancer and Developmental Biology, California State University, Northridge, The FASEB Journal. 2006; 20:A227.

Elizabeth Willott, Larry Thrower, Bram Taarea, Panteha Kiaei, Leslie Pittman, Alex Rogers, Tina Trenczek, Michael R. Kanost, Identification and purification of a Manduca sexta hemocyte protein, HDMS17, that decreases in abundance in hemocytes after bacteria-challenge.

Resume Overview

Companies Worked For:

Amgen Inc, Dept. of Clinical Biomarkers & Diagnostics
Amgen Inc, Dept. of Molecular Sciences
Amgen Inc, Dept. of Functional Genomics
The University of Arizona, Dept. of Entomology

School Attended

The University of Arizona
California State University, Northridge

Job Titles Held:

Senior Associate Scientist
Associate Scientist
Senior Associate
Research Associate I
Research Assistant

Degrees

Bachelor of Science : Molecular and Cellular Biology , 2000
Master of Science : Biology , In Progress

Senior Associate Scientist Resume Example

Resume Score: 70%

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