To secure a rewarding research position in the pharmaceutical industry. Cell and molecular biologist with 15 years of experience in cardiovascular research; Organized complex studies involving multiple institutes and facilitating external collaborations; Built and led successful research teams, with established solid procedure and protocols for entire study group; Prepared funded federal grant applications, published manuscripts in high profile journals, and presented valuable results in prestigious conferences such as AHA , ADA and ACC scientific session.
1.Ke LY, Chan HC, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH*, Chen CH*. Enhanced sphingomyelinase activity in apolipoprotein B100 contributes to the atherogenicity of electronegative LDL. J Med Chem. 2015; in press.
2.Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T, and Chen CH. Interplay Between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis. Clinical Chemistry. 2015 Nov 25. PMID: 26607724.
3.Hsu JF, Chou TC, Lu J, Chen SH, Chen FY, Chen CC, Chen JL, Elayda M, Ballantyne CM, Shayani S, Chen CH. Low-density lipoprotein electronegativity is a novel cardiometabolic risk factor. PLoS One. 2014, 9(9):e107340.
4.Lu YC, Chen CN, Chu CY, Lu J, Wang BJ, Chen CH, Huang MC, Lin TH, Pan CC, Chen SS, Hsu WM, Liao YF, Wu PY, Hsia HY, Chang CC, Lee H. Calreticulin activates 1 integrin via fucosylation by fucosyltransferase 1 in J82 human bladder cancer cells. Biochem J. 2014, 460(1):69-78.
5.Chan HC, Ke LY, Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HB, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH, Chen CH. Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 2013, 122(22):3632-41.
6.Chu CS, Wang YC, Walton B, Yilmaz HR, Huang RY, Sawamura T, Lu LS, Chen CH, Lu J*. Electronegative low-density lipoprotein increases endothelial expression of C-reactive protein through LOX-1 receptor. PLoS One. 2013, 8(8):e70533.
7.Chang PY, Chen YJ, Chang FH, Lu J, Huang WH, Yang TC, Lee YT, Chang SF, Lu SC, Chen CH. Aspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: A novel cytoprotective role of aspirin in acute myocardial infarction. Cardiovasc Res. 2013, 99(1):137-45.
8.Tsai MH, Chang CL, Yu YS, Lin TY, Chong CP, Yang JY, Lin YS, Su MY, Shu TY, Lu J, Chen CH, Liu MY. Chemical analysis of C-reactive protein synthesized by human aortic endothelial cells under oxidative stress. Anal Chem. 2012, 84:9646-9654.
9.Chen CH, Lu J, Chen SH, Huang RY, Yilmaz RH, Dong JW, Elayda MA, Dixon RA, Yang CY. Effects of Electronegative VLDL on Endothelium Damage in Metabolic Syndrome. Diabetes Care. 2012, 35(3):648-53.
10.Ke LY, Engler DA, Lu J, Matsunami RK, Chan HC, Wang GJ, Yang CY, Chang JG, Chen CH. Chemical composition–oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein. Pure Appl Chem. 2011, 83:1731–1740. doi:10.1351/PAC-CON-10-12-07
11.Lu J, Yang JH, Burns AR, Chen HH, Tang D, Walterscheid JP, Suzuki S, Yang CY, Sawamura T, Chen CH. Mediation of electronegative LDL signaling by LOX-1: A possible mechanism of endothelial apoptosis. Circ Res. 2009, 104:619-627.
12.Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WSL, Yang CY, Chen CH. Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting FGF2 autoregulation. Diabetes. 2008, 57:158-166.
1.Ke LY†, Chan HC, Chen CC, Lu J, Marathe GK, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH, Chen CH. O-Glycosylation of ApoB100 is associated with enhanced sphingomyelinase activity and atherogenicity of human electronegative LDL. Presented at the American Heart Association Scientific Sessions in Orlando, FL, November 7–11, 2015.
2.Hsu JF, Chou TC, Hsieh JY, Lu J, Chen SH, Shayani S, Chen CH. A novel total lipoprotein electronegativity index for predicting cardiometabolic risk. Submitted to the American Diabetes Association 73rd Scientific Sessions in Chicago, Illinois, June 21-25, 2013.
3.Wang YC, Lu LS, Dong JW, Lu J, Lee AS, Chen SH, Dou H, Kuzan TY, Chang KC, Dixon RA, Chen CH. The DNA Damage Response Mediates Endothelial Cell Senescence Induced by Electronegative LDL. Circulation 2012;126:A16796. Presented at the American Heart Association Scientific Sessions in Los Angeles, CA, November 3–7, 2012.
4.Chang KC, Wang YC, Chang SS, Lo PH, Lu J, Sawamura T, Lee YT, Burns AR, Chen CH. Expression of the Highly Electronegative LDL Receptor LOX-1 is Increased in Thrombi of STEMI Patients. Circulation 2012;126:A13127. Presented at the American Heart Association Scientific Sessions in Los Angeles, CA, November 3–7, 2012.
5.Wang YC, Lu J, Chen SH, Dong JW, Huang RY, Dixon RAF, Elayda MA, Chen CH. Electronegative low-density lipoprotein is increased early in cardiometabolic derangement. Published for the American Diabetes Association 72nd Scientific Sessions in Philadelphia, Pennsylvania, June 8-12, 2012.
6.Dong JW, Yilmaz HR, Lu J, Lu LS, Chen SH, Wang YC, Dixon RAF, Chen CH. Mitochondrial damage by electronegative low-density lipoprotein in metabolic syndrome. Published for the American Diabetes Association 72nd Scientific Sessions in Philadelphia, Pennsylvania, June 8-12, 2012.
7.Lu J*, Chu CS, Wang YC, Dong JW, Chen SH, Huang RY, Chen CH. Electronegative Low-Density Lipoprotein Increases Endothelial Expression of C-Reactive Protein Through LOX-1 Receptor. Presented at the 61st American College of Cardiology's (ACC's) Scientific Session in Chicago, IL, March, 2012.
8.Chen CH, Lu J, Dean J, Huang RY, Wang YC, Elayda M, Dong JW, Chen SH, Dixon RA. Mechanistic Implication of Electronegative Low-Density Lipoprotein Surge in Acute Myocardial Infarction. Presented at the 61st American College of Cardiology's (ACC's) Scientific Session in Chicago, IL, March, 2012.
9.Ma Y, Lu J, Cheng N, Wu G, Abbasi S, Cheng J, Chen CH, Xi Y. L5 induces cardiomyocytes damage and reduction of cardiac ATP-sensitive K+ Channels. J Am Coll Cardiol. 2012;59:E1055. Presented at the 61st American College of Cardiology Scientific Sessions in Chicago, IL, March 24–27, 2012.
10.Lu J*, Chu CS, Yilmaz HR, Dong JW, Chen SH, Huang RY, Sawamura T, Chen CH. Atorvastatin Decreases Atherogenic Low-Density Lipoprotein, Which Induces the Endothelial Expression of C-Reactive Protein. Accepted by the American Heart Association Basic Cardiovascular Sciences 2011 Scientific Sessions, July 23-26, New Orleans, LA.
11.Chen CH, Lu J, Engler DA, Ke LY, Yilmaz HR, Dixon RA, Chen SH, Yang CY. Biological Significance of Charge-Based Heterogeneity in Diabetic VLDL Subfractions. Presented at the 71st American Diabetes Association Scientific Sessions in San Diego, CA, June 24 - 28, 2011.
12.Cheng N, Lu J, Sun JP, Wu GR, Abbasi S, Zhang J, Cheng J, Chen CH, Xi YT. Most Negatively Charged Subfraction (L5) of Plasma LDL Prolongs Action Potential Duration of Rat Cardiomyocytes via Lox-1 Receptors. Presented at the 60th American College of Cardiology Scientific Sessions in New Orleans, LA, April 2-5, 2011.
13.Lu J*, Wang GJ, Tung CH, Chan HC, Han MS, Ke LY, Poucher SM, Chen CH. Electronegative LDL in cardiometabolic disorders unleashes converting enzyme-regulated endothelin-1 synthesis normally modulated by Akt in vascular endothelial cells. Presented at the 4th International Congress on Prediabetes and the Metabolic Syndrome, Madrid, Spain, April 6-9, 2011.
14.Dixon R.A., Lu J, Chen CH. Negatively charged LDL subfraction contributes to both atherosclerosis and hypertension in type 2 diabetes. Presented at The 3rd World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy). Prague, Czech Republic, May 13-16, 2010.
15.Tang D, Burns AR, Lu J, Chen HH, Wu H, Morrisette JL, Sawamura T, Yang CY, Chen CH. Electronegative LDL disrupts mitochondrial homeostasis: a novel mechanism for cigarette smoking-associated endothelial dysfunction. Presented at the FASEB 2008 meeting, San Diego, CA, April 5–9, 2008.
16.Tang D, Chen HH, Lu J, Engler DA, Sawamura T, Pownall HJ, Yang CY, Chen CH. Chronic smoking-yielded electronegative LDL induces MEK/ERK mediated metalloproteinase activation in human endothelial progenitor cells. J Am Coll Cardiol. 2008;51(suppl A):A278. Presented at the American College of Cardiology 2008 Scientific Sessions, Chicago, IL, March 29–April, 2008.
17.Tang D, Lu J, Walterscheid JP, Chen HH, Yang JH, Engler DA, Sawamura T, Marcelli M, Yang CY, Chen CH. Electronegative LDL in smoking subjects inhibits endothelial progenitor cell differentiation by impairing Akt phosphorylation via the LOX-1 receptor. Arterio Thromb Vasc Biol. 2007; Presented at the ATVB Annual Conference April 19-21, 2007 Chicago, IL.
18.Lu J*, Walterscheid JP, Chen HH, Yang CY, Poucher SM, Chen CH. Diabetic LDL subfraction induces smooth muscle cell proliferation by enhancing endothelial release of endothelin-1. Diabetes. 2006;55 (suppl 1):A160. Presented at the American Diabetes Association 66th Scientific Sessions in Washington DC. June 9–13, 2006.
19.Lu J*, Chen HH, Yang CY, Waltersheid JP, Pownall HJ, Morrisett JD, Chen CH. C4 Platelet-activating factor mimics electronegative LDL circulating in patients with metabolic syndrome in inducing endothelial cell apoptosis. Diabetes. 2005;54(suppl 1):A193. Presented at the American Diabetes Association 65th Scientific Sessions in San Diego, CA, June 10–14, 2005.
20.Lu J*, Yang JH, Chen HH, Yang CY, Henry PD, Walterscheid JP, Morrisett JD, Sawamura T, Chen CH. Effective attenuation of electronegative LDL-induced endothelial cell apoptosis by gene silencing of the lectin-like receptor for oxidized LDL. J Am Coll Cardiol. 2005. Presented at the 54th American College of Cardiology Scientific Sessions in Orlando, FL, March 6–9, 2005.
21.Tai MH, Kuo SM, Huang MT, Yang JH, Chen HH, Lu J, Sawamura T, Chen CH, Yang CY. Activation of caspase 13 by diabetic electronegative LDL through lectin-like oxidized LDL receptor-1 (LOX-1) in vascular endothelial cells. Circulation. 2005;112:II-1105. Presented at the American Heart Association 2005 Scientific Sessions, Dallas, TX, November 11-16, 2005.
22.Lu J*, Marcelli M, Liao WSL, Yang JH, Henry PD, Yang CY, Pownall HJ, Chen CH. Dominant-negative Akt impairs endothelial cell survival by mimicking the inhibitory effect of electronegative LDL on FGF2 transcription. Circulation. 2004;110-III87. Presented at the American Heart Association 2004 Scientific Sessions, New Orleans, LA, November 7-10, 2004.
23.Chen CH, Pace PW, Karakoc ND, Lu J, Chen HH, Henry PD, Pownall HJ, Foreyt JP, Ballantyne CM, Yang CY. Effective reduction of novel atherogenic LDL subfraction by atorvastatin in patients with hypercholesterolemia. J Am Coll Cardiol. 2004;43(suppl A):486A. Presented at the 53rd American College of Cardiology Scientific Sessions in New Orleans, LA, March 7–10, 2004.
24.Lu J*, Chen HH, Suzuki S, Yang CY, Henry PD, Sawamura T, Chen CH. Role of the LOX-1 receptor in transducing the apoptotic signals of circulating atherogenic LDL. J Am Coll Cardiol. 2004;43(suppl A):26A. Presented at the 53rd American College of Cardiology Scientific Sessions in New Orleans, LA, March 7–10, 2004.
25.Jiang W, Lu J, Yang JH, Chang PY, Lee YT, Marcelli M, Henry PD, Liao WSL, Chen CH. Atherogenic LDL impairs vascular endothelial cell survival by disrupting the FGF2-PI3K-Akt autoregulatory loop. J Am Coll Cardiol. 2004;43(suppl A):499A. Presented at the 53rd American College of Cardiology Scientific Sessions in New Orleans, LA, March 7–10, 2004.
26.Lu J*, Marathe GK, Yang CY, Jiang W, Yang JH, Pownall HJ, Henry PD, Chen CH. Platelet-activating factor-like lipids mediate endothelial cell apoptosis induced by hypercholesterolemic LDL. J Am Coll Cardiol. 2003;41(Supple):243A. Presented at the 52nd American College of Cardiology Scientific Sessions in Chicago, IL, March 30–April 2, 2003.
27.Chen CH, Jiang T, Yang JH, Jiang W, Pownall HJ, Ballantyne CM, Lu J, Henry PD, Yang CY. Induction of vascular endothelial cell apoptosis through the platelet-activating factor receptor in hypercholesterolemia. Atherosclerosis. 2002;3:88. Presented at the 73rd European Atherosclerosis Society Congress, Salzburg, Austria, July 7-10, 2002.
28.Lu J*, Suzuki S, Safi HJ, Jiang W, Henry PD, Yang JH, Morrisett JD, Chen CH. OxLDL LDL-induced vascular endothelial cell apoptosis involves ceramide-mediated Akt dephosphorylation: protective role of FGF2 overexpression. Atherosclerosis. 2002;3:88. Presented at the 73rd European Atherosclerosis Society Congress, Salzburg, Austria, July 7-10, 2002.
29.Jiang W, Lu J, Chang PY, Yang JH, Henry PD, Marcelli M, Chen CH. Oxidized LDL induces endothelial cell apoptosis by impairing the FGF2-PI3K-Akt pathway. Circulation. 2002;105:e86-e119. Presented at the American Heart Association-Asia Pacific Scientific Forum, Honolulu, Hawaii, April 23-26, 2002.
30.Lu J*, Suzuki S, Safi HJ, Jiang W, Henry PD, Yang CY, Chen CH. FGF2 overexpression prevents ceramide-mediated Akt deactivation in endothelial cells exposed to oxidized LDL. Arterioscler Thromb Vasc Biol. 2002;22:878-a. Presented at the American Heart Association-3rd Annual ATVB council meeting, Salt Lake City, Utah, April 6-8, 2002.
31.Chen CH, Yang JH, Morrisett JD, Lu J, Jiang T, Henry PD, Yang CY. Proapoptotic activity of a novel LDL subfraction in hypercholesterolemic human plasma. Circulation. 2001;104:II297. Presented at AHA 2001 Scientific Sessions 2001 of the American Heart Association, Anaheim, CA, November 11-14, 2001.
•American Diabetes Association
•American Heart Association, Atherosclerosis Council
•International Atherosclerosis Society
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