Experienced senior scientist with over 15 years of experience in biomedical research field from basic research to disease-related translational studies. Her expertise includes cell biology, molecular biology, immunology, innate immunity of viral recognition and host defense and skin inflammatory diseases. She is always enthusiastic and eager to team success through hard work, attention to detail, excellent organization skills and leadership of encouraging creative work environment.
Cell culture including cell lines and primary keratinocytes and fibroblasts
Conduct research to identify risk factors causing increased viral infections in atopic dermatitis patients. To be specific:
1. Design study protocols to investigate blood and skin specimens collected from atopic dermatitis patients, atopic dermatitis patients with a history of disseminated herpes simplex virus infections (eczema herpeticum) and normal non-atopic healthy individuals.
2. Design in vitro and in vivo experimental systems to investigate the roles of candidate genes, genetic variants and pathways in the pathogenesis of atopic dermatitis and eczema herpeticum using a variety of cellular, molecular and immunological approaches.
3. Write scientific manuscripts and grant applications to apply for fundings from NIH agency and pharmaceutical companies.
4. Train and supervise technicians in the laboratory to conduct projects.
Conduct research to investigate atopic dermatitis.
1. Investigated the roles of S100 proteins in keratinocytes' host defense against viccinia virus infection.
2. Investigated the roles of specific protein 1 in keratinocytes' biology and host defense aganist herpes simplex virus and vaccinia virus infection.
3. Investigated the effects of staphylococcus aureus virulent factors in keratinocyte viral infections.
4. Wrote scientific manuscripts, presented scientifc data in American Academy of Allergy, Asthma and Immunology annual meetings.
1. Investigated different formats of TRAIL agonists in killing cancer cells with different TRAIL receptor mutations found in human cancer patients.
2. Investigated different chemotherapy drugs in overcoming cancer cells' resistance to TRAIL induced apoptosis.
Conducted research to identify novel genes involved in TRAIL and TLR signaling pathways.
1) Utilized retroviral-based mammalian expression libraries to identify genes that confer resistance to TRAIL-induced apoptosis.
2) Utilized retroviral-based mammalian expression libraries and identified that Marco was the unique receptor of a lung soluble protein, Uteroglobin- related protein 1.
3) Identified the interaction partners of an adaptor protein TIRP (TICAM2) in TLR4 signaling pathway.
4) Made and analyzed the phenotypes of RELT transgenic mice.
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