Motivated and well-qualified Oncologist Research Associate knowledgeable about developmental biology, gene expression and transcription, cellular/molecular cancer biology and epigenetics. Offering [Number]-year background as data reviewer, recordkeeper and project coordinator. Intelligent and enterprising professional always pursuing ways to streamline or optimize processes. Meticulous and analytical Researcher with [Number] years of educational and hands-on experience in [Area of expertise]. Adaptive team player with in-depth knowledge of data collection, confidential document control and problem-solving.
Skills
[Type] analysis
Reporting requirements
Research and Analysis
Reporting Standards
Literature Reviews
Lab Operations
Documentation skills
Expertise in [Method]
Grant writing
Experimental design
Technical Writing
Documentation expertise
Research program planning
Method validation
Data analysis
Research grants
Good Laboratory Practices (GLP)
Work History
05/2018 to Current
Research AssociateIcon – Hickory, NC,
Contributed to and actively participated in research conception, design and execution to address defined problems.
Maintained accurate records of research findings and provided statistical analysis of data results.
Contributed to grant writing process; reviewing, writing/editing scientific research manuscripts, reports and experimental protocols and highlighted possible applications for findings.
Leveraged interpersonal and communication skills to mentor PhD, graduate and undergraduate students.
Attended research seminars and collegiate meetings to discover and discuss new technologies and research.
Collaborated with colleagues to gather research and publish findings.
Completed analysis of data acquired from research and verified careful documentation of all information.
Maintained records of research findings with analysis and evaluation of results.
Conducted independent oncology research, mainly relate with gene transcription, signaling, and cellular/molecular biology.
05/2013 to 05/2016
Postdoctoral Fellow ResearchUniversity Of Arkansas – Monticello, MN,
Conducted research guided by faculty supervisor.
Collaborated with others professionals to advance research and gain deeper understanding of topics.
Performed lab maintenance, including replenishing stock levels, replacing or repairing broken equipment and enforcing sterilization procedures.
Reviewed and analyzed historical and emerging literature to develop and practice new technologies.
07/2007 to 04/2013
Graduate Research FellowUniversity Of Arkansas – Benton, ,
Followed best practices and scientific protocol to reach defensible conclusions based on solid evidence.
Conducted research guided by faculty supervisor. Particularly studying the Fetal Alcohol Spectrum Disorders and effect on normal embryo patterning.
03/2006 to 07/2007
Undergraduate Research AssistantInstitute Of Cell Biology And Neuros., Argentina – City, ,
Planned, modified, and executed research techniques, procedures and tests.
Assisted faculty members with research assignments on early stages of patterning and studies of normal development projects (xenopus, zebra fish and chick embryos).
02/2003 to 07/2006
Undergraduate Research AssistantNational University Of Misiones, Argentina – City, ,
Recorded data and maintained source documentation following good documentation practices.
Collected, prepared and organized wide range of biological samples.
Education
Expected in 04/2013
Ph.D.: Biology/Developmental Biology National University of Cordoba, Argentina. - Cordoba, Argentina, GPA:
Thesis: "Sonic Hedgehog Signaling Pathway InducesDirectional Migration of Neural Crest Cells and is Altered by Ethanol Exposure"
Expected in 07/2007
Master of Science: Genetics National University of Misiones, Argentina. - Posadas, Misiones, Argentina., GPA:
Accomplishments
Peer-reviewed Articles
Claire EJ, Jaurena MB, Zanin JP, Battiato NL and Rovasio RA. In situ hybridization of chemotactically bioactive molecules on cultured chick embryo. Journal of Histotechnology, 2012; 35(3):114-129. Doi: 10.1179/2046023612Y.0000000008.
Nye MD, Almada LL, Fernandez-Barrena MG, Marks DL, Elsawa SF, Vrabel A, Claire EJ, Ellenrieder V and Fernandez-Zapico ME. The transcription factor GLI1 interacts with SMAD proteins to modulate TGF beta-induced gene expression in PCAF-dependent manner. J Biol Chem, 2014 May 30;289(22):15495-506. doi: 10.1074/jbc.M113.545194.
Nitzki F, Claire EJ, Cuvelier N, Frommhold A, Salinas-Riester G, Johnsen SA, Fernandez-Zapico ME and Hahn H. Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy. Oncotarget, 2015 Apr 20;6(11):9113-24. doi: 10.18632/oncotarget.3272.
Jackson DA, Smith TD, Amarsaikhan N, Neil MS, Boi SK, Vrabel A, Claire EJ, Almada LL, Fernandez-zapico ME and Elsawa SF. Modulation of the IL-6 Receptor alpha underlies GLI2-mediated regulation of immunoglobulin secretion in Walderström macroglobulinemia cells. J Immunol, 2015 Sep 15;195(6):2908-16. doi: 10.4049/jimmunol.1402974.
Comba A, Almada LL, Claire EJ, Iguchi E, Marks DL, VaraMessler M, Silva R, Fernandez-Barrena MG, Enriquez-Hesles E, Vrabel AL, Botta B, Di Marcotulio L, Ellenrieder V, Eynard AR, Pasqualini ME and Fernandez-Zapico ME. Nuclear factor of activated T cells-dependent down regulation of the transcription factor GLI1 underlies the growth inhibitory properties of arachidonic acid. J Biol Chem, 2016 Jan 22;291(4):1933-47. doi: 10.1074/jbc.M115.691972.
Claire EJ, Fernandez-Zapico ME, Battiato NL and Rovasio RA. Sonic Hedgehog is a chemotactic neural crest cells guide that is perturbated by ethanol exposure. Eur J Cell Biol, Mar-May 2016;95(3-5):136-52. doi: 10.1016/j.ejcb.2016.02.003.
Wu M, Ingram L, Claire EJ, Vera RE, Li Q, Kim S, Ma Y, Spyropoulos DD, Beharry Z, Huang J, Fernandez-Zapico ME and Cai H. Gli transcription factors mediate the oncogenic transformation of prostate basal cells induced by a Kras-androgen receptor axis. J Biol Chem, 2016 Dec 2;291(49):25749-25760. doi: 10.1074/jbc.M116.753129.
Claire EJ*, Chen G*, Nakamura I*, Dhanasekaran R*, Iguchi E*, Romecin PA, Vera RE, Almada LL, Miamen AG, Chaiteerakij R, Zhou M, Asiedu MK, Moser CD, Han S, Hu C, Banini BA, Oseini AM, Chen Y, Fang Y, Yang D, Shaleh HM, Wang S, Wu D, Song T, Lee JS, Thorgeirsson SS, Chevet E, Shah VH, Fernandez-Zapico ME and Roberts LR. Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma. Cancer Res, 2017 Feb 1;77(3):632-645. doi: 10.1158/0008-5472.CAN-15-2556. (*These authors contributed equally to this work).
Egan JB, Marks DL, Hogenson TL, Vrabel AM, Sigafoos AN, Claire EJ, Safgren SL, Enriquez Hesles E, Almada LL, Romecin PA, Iguchi E, Aldeen AA, Kocher JP, Oliver GR, Prodduturi N, Mead DW, Hossain A, Huneke NE, Tagtow CM, Ailawadhi S, Ansell SM, Banck MS, Bryce AH, Carballido EM, Chanan-Khan A, Curtis KK, Elliott MA, Gawryletz CD, Go RS, Halfdanarson TR, Ho TH, Joseph RW, Kapoor P, Mansfield AS, Nageswara Rao AA, Nowakowski GS, Pardanani A, Parikh SA, Cheville JC, Feldman AL, Ramanathan RK, Robinson SI, Tibes R, Finnes HD, McCormick JB, McWilliams RR, Jatoi A, Patnaik MM, Silva AC, Wieben ED, McAllister TM, Rumilla KM, Kerr SE, Konstantinos N. Lazaridis KN, Farrugia G, Stewart AK, Clark KJ, Kennedy EJ, Klee EW, Borad MJ and Fernandez-Zapico ME. Functional analysis of exome sequencing-derived variants of unknown significance identifies a novel constitutively active FGFR2 mutant in cholangiocarcinoma. JCO Precis Oncol, 2017;2017:PO.17.00018. doi: 10.1200/PO.17.00018.
Koutsioumpa M, Hatziapostolou M, Polytarchou C, Claire EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez B, Sara Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernandez-Zapico ME and Iliopoulos D. Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Gut, 2019 Jul;68(7):1271-1286. doi: 10.1136/gutjnl-2017-315690.
Ha Y, Fang Y, Romecin Duran PA, Claire EJ, Moser CD, Fernandez-Zapico ME and Roberts LR. Induction of Lysosomal protein transmembrane 4 Beta via sulfatase 2 enhances autophagic flux in liver cancer cells. Hepatol Commun, 2019 Sep 25;3(11):1520-1543. doi: 10.1002/hep4.1429.
McCleary-Wheeler AL, Carr RM, Palmer SR, Smyrk TC, Allred JB, Almada LL, Claire EJ, Lamberti MJ, Borad MJ, Molina JR, Qi Y, Lingle WL, Grothey A, Pitot HC,Jatoi A, Northfelt DW, Bryce AH, McWilliams RR, Okuno SH, Haluska P, Kim GP, Colon-Otero G, Lowe VJ, Callstrom MR, Ma WW, Bekaii-Saab T, Hung MC, Erlichman C and Fernandez-Zapico ME. Phase 1 trial of vismodegib and erlotinib combination in metastatic pancreatic cancer. Pancreatology, 2020 Jan;20(1):101-109. doi: 10.1016/j.pan.2019.11.011.
Carr RM, Romecin Duran PA, Claire EJ, Ma C, Oseini AM, Moser CD, Banini BA, Huang J, Asumda F, Dhanasekaran R, Graham RP, Toruner MD, Safgren SL, Almada LL, Wang S, Patnaik MM, Roberts LR, Fernandez-Zapico ME The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex. J Biol Chem, 2020 Feb 28;295(9):2698-2712. doi: 10.1074/jbc.RA119.011146.
Claire EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF and Fernandez-Zapico ME. GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression. Biochem Journal, 2020 Sep 18;477(17):3131-3145. doi: 10.1042/BCJ20200335. *Commentary. Timmis AJ and Riobo-Del Galdo NA. Another twist to the GLI code. Biochemical Journal, (2020); 477 (22): 4343–47.
Franchi F, Peterson KM, Quandt K, Domnick D, Kline TL, Olthoff M, Parvizi M, Claire EJ, Harris PC, Fernandez-Zapico ME, Rodriguez-Porcel MG. Impaired Hedgehog-GLI1 pathway activity underlies the vascular phenotype of Polycystic Kidney Disease. Hypertension 2020 Dec;76(6):1889-1897. doi: 10.1161/HYPERTENSIONAHA.120.15483.
MG, Eidenschink BB, Iguchi E, Zakharkin SO, LaRocca CJ, Claire EJ, Truty MJ, Jacobsen K, Fernandez-Zapico ME, Davydova J. Cancer Imaging and Therapy Utilizing A Novel NIS-expressing Adenovirus - The Role of Adenovirus Death Protein Deletion. Molecular Therapy: Oncolytics, 2021, doi: 10.1016/j.omto.2021.03.
Carr RM, Vorobyev D, Lasho T, Marks DL, Claire EJ, Vedder A, Almada LL, Yurchenko A, Padioleau I, Alver B, Coltro G, Binder M, Safgren SL, Horn I, You X, Droin N, Solary E, Balasis ME, Berger K, Pin C, Witzig T, Buradkar A, Graf T, Valent P, Mangaonkar AA, Robertson KD, Howard MT, Kaufmann SH, Fernandez-Zapico ME, Geissler K, Padron E, Zhang J, Nikolaev S, Patnaik MM. RAS mutations drive proliferative chronic myelomonocytic leukemia via activation of a novel KMT2A-PLK1 axis. Nat commun, 2021 May;12(1):2901. doi: 10.1038/s41467-021-23186-w.
Oliver GR, Marcano-Bonilla S, Quist J, Claire EJ, Iguchi E, Swanson A, Hoppman NL, Schwab T, Sigafoos AN, Prodduturi N, Voss JS, Knight SM, Zhang J, Fadra N, Urrutia R, Zimmerman M, Egan JL, Bilyeu AG, Jen J, Veras E, Almarzooqi S, Al-Safi R, Ronnett BM, Block M, Kerr S, Fernandez-Zapico ME, Schoolmeester JK, Klee EW. LPCAT1-TERT Fusion, A Uniquely Recurrent Genetic Event in Epithelioid Trophoblastic Tumors, Positively Regulates Cell Growth. PLoS One. 2021 May;16(5):e0250518. doi: 10.1371/journal.pone.0250518.
Affiliations
Cancer Epigenetics Society (CES).
American Association for Cancer Research (AACR).
Additional Information
Honors, Awards and Fellowships
Research Assistant Fellowship. Secretary of Science and Technology. National University of Misiones, Argentina. 03/2003.
Research Assistant Fellowship. Secretary of Science and Technology. National University of Misiones, Argentina. 03/2004.
Doctoral Fellowship. National Council of Scientific and Technical Research (CONICET) and Ministry of Science and Technology of Cordoba, Argentina. 04/2008 - 05/2013.
Oral Presentation - International Association of Pancreatology (IAP) - 1st IAP/LAPSG Joint Meeting, Buenos Aires, Argentina. 09/2017.
Conquer Cancer Foundation of ASCO Merit Award - ASCO Meeting, Chicago, Illinois. 05/2019.
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