Supervise, taught, and trained research assistants and summer students in the group.
Directed recruitment of new personnel. I organize seminars for the group. During this time,
Developed strong problem-solving skills and encouraged teamwork.
Established collaborations with other groups.
Helped students, postdocs, and junior faculty from other laboratories design and analyze experiments.
Improved my critical thinking, which facilitates the evaluation, explanation, and interpretation of results.
Supervision and training
Complex problem solving
Research and Analysis
Extensive Organizational Skills
09/2015 - Current
University Of Texas Health Science Center At Houston － Houston, TXProgram Manager/ Research Laboratory Manager
Provide day-to-day operations management to the cerebrovascular research center, a multi PIs research group (6 PIs, 8 postdocs, 9 RAs, 7 students).
Support multiple research projects guiding students, RAs, and postdocs to achieve assigned goals and career development.
Authorize expenditures for multiple projects from several principal investigators (~2M per year).
Supervise and process the purchasing of complex departmental equipment.
Managed and reconciled accounts for multiple projects as well as salaries and general operations budget (9 funds).
Manage human resources activities for direct reports in regards to recruiting and selection, hiring and termination, training, professional development, mentoring, counseling, performance evaluations, and salary planning.
Develop and initiate internal processes to improve organization.
Establish goals and milestones for the group to achieve desired goals.
Define the resources required for completion of a project and allocated funds accordingly.
Evaluate the timely performance of different team member working on various projects and documented the progress.
Coordinated multi PIs collaborations from different institutions.
12/2013 - 09/2015
The University of Texas Health Science Center at Houston － Houston, TXSenior Research Assistant/ Research Laboratory Manager
Authorized expenditures for multiple projects (over 500k per year), improving spending control through the implementation of an itemized budget.
Reviewed processes and identified wasteful spending that resulted in a significant reduction in operational cost (200K overspending in 2009 to 60K surplus in 2014).
Established relationships with sales representatives achieving better prices for The Mitchell's Center consumables (Ex.
80k in protein gels a year to 42K).
Assisted, negotiated, and recommended purchasing of complex equipment to ensure equipment functionality/price ratio.
09/2009 - 12/2013
The University of Texas Health Science Center at Houston － Houston, TXResearch Assistant II/Research Laboratory Manager
Supervised and coordinated the biosafety compliance for different projects that resulted in optimal evaluations in each biyearly biosafety and chemical inspections.
Developed and implemented a new system to record and store experimental data improving the accessibility and reliability of the information for each member of in the Mitchell Center.
Contracted and negotiated service agreements to maintain equipment functionality assuring laboratory productivity.
07/2009 - 09/2009
The University of Texas Health Science Center at Houston － Houston, TXResearch Assistant I/Research Laboratory Manager
Directed the animal facility (over 20 transgenic mouse lines), improving organization and record of mice experiments.
Managed day-to-day Mitchell Center laboratory coordination increasing laboratory operation and organization.
Provided laboratory safety training to new personnel to assure safe laboratory practices.
03/2009 - 07/2009
The University of Texas Health Science Center at Houston － Houston, TXResearch Assistant I
Developed and standardized techniques to process animal samples in house eliminating high costs of third party services.
Education and Training
Arkansas State UniversityJonesboro, ARMasters of Business Administration
Los Andes UniversitySantiago, ChilePh.D.: Biomedical SciencesBiomedical Sciences
Austral University of ChileValdivia, ChileB.S: Sciences BiologySciences Biology
Activities and Honors
2015- Present American heart Association
Morales-Scheihing D., Mukherjee A., Salvadores N., Moreno-Gonzalez I., Gonzalez C., Taylor-Presse K., Mendez N., Shahnawaz M., Gaber AO., Sabek OM., Fraga DW., Soto C.. Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism. J Exp Med. 2017 Sep 4;214 (9):2591-2610. doi: 10.1084/jem.20161134.
Mukherjee A., Morales-Scheihing D., Butler PC, Soto C. Type 2 Diabetes as a Protein Misfolding Disease. Trends Mol Med. 2015 Jul;21(7):439-49. doi: 10.1016/j.molmed.2015.04.005.
Mukherjee A., Morales-Scheihing D., Gonzalez-Romero D., Green K., Taglialatela G., Soto, C. Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival. PLoS Pathog. 2010 Oct 7;6(10): e1001138. doi: 10.1371/journal.ppat.1001138.
Morales R., Estrada LD., Diaz-Espinoza R., Morales-Scheihing D., Jara MC., Castilla J., Soto C. Molecular cross talk between prions and amyloids in animal models of Alzheimer's and prion diseases. J Neuroscience. 2010 Mar 31;30(13):4528-35. doi: 10.1523/JNEUROSCI. 5924-09.2010.
PUBLICATIONS SUBMITTED OR IN PREPARATION
Morales R., Duran-Aniotz C., Estrada L., Urayama A., Morales-Scheihing D., Soto C. Induction of amyloid deposition and memory impairments in animal models of Alzheimer's disease by blood transfusion. Manuscript in preparation.
Urayama A., Kharat V., Morales-Scheihing D., Moreno-Gonzalez I., Soto C. Reversal of Alzheimer's disease pathogenesis by renewing blood. Manuscript in preparation.
Estrada L.D., Shahnawaz M., Urayama A., García V., Morales-Scheihing D., Bieler S., Lagos R. and Soto C. A novel strategy for cancer treatment using bacterial amyloid aggregates. Manuscript in preparation.
Cellular/molecular Biology,Genetics, Neuroscience, and Biochemistry.
Type 2 Diabetes, neurodegenerative diseases, protein misfolding disorders, Prion diseases, and Stroke.
Utilization of In vitro, Ex vivo and In
Vivo models of experimentation with
techniques such as flow cytometry and cell sorting; molecular cloning; protein
expression and purification; DNA/RNA isolation; multiplex; ELISA; PCR; RT-PCR;
digital fluorescence imaging; confocal microscopy; gel electrophoresis; HPLC;
spectroscopy; Light Microscopy; TEM; ultra-centrifugation; quantitative immunohistochemistry/immunofluorescence;
rodent behavioral test and software analysis; cell culture; primary culture,
statistics. Adobe Illustrator, Adobe Photoshop,