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Manager, R&D project management, Research Resume Example

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MANAGER, R&D PROJECT MANAGEMENT, RESEARCH
Professional Overview

A PhD level Scientific Manager with Biomedical international education, and start up life sciences experiences on both Research and Operational management.

Core Strengths
  • Project/product management
  • Collaborative approach to internal&external research projects
  • Innovative&Creative thinker
  • Passion in technology application
  • Publications
Accomplishments

  • In Complete Genomics Inc.Research team, project/product management of top profile research projects, such as Aging, Autism, Cancer and prenatal diagnostic studies, co-manage "healthy human baseline" project from BGI. Co-edit papers from BGI.
  • In Complete Genomics Inc.production team, manage 26 Next Generation Sequencing machines, and direct sequencing production group (11 people) 24/7, 365 days to complete day to day activities. Lead the team to meet operational plans, milestones and goals.
  • In Complete Genomics Inc.production team, train CLIA scientists, prepare the sequencing group to become CLIA ready, become familiar with regulatory guidelines for Next Generation Sequencing.
  • In Complete Genomics Inc.sequencing chemistry team, develop and optimize the process of sequencing, in authorship of 2 papers in Nature and Science.
  • Publish 6 papers and obtain various grants and scholarships throughout academic experiences
  • Certified Six sigma Blackbelt bearer , Certified Dale Carnegie Leadership trained Manager.
Experience
03/2012 to Current
Manager, R&D project management, Research Company Name - City, State
  • Responsible for high profile research projects such as Aging, Autism, Cancer and prenatal diagnostic studies, co-manage "individual human baseline" project from BGI, contribute both scientific/technical and project/product management aspects.
  • Manage staff, budget and resources to achieve quick turn around on collaboration projects, track on progress, involve in scientific discussions and manuscript generation. Co-edited 2 papers for BGI that resulted in publication.
  • In authorship of paper in Nature (2012), where the first time demonstrates accurate haplotype sequencing from small number of cells using Long fragment read technology: In authorship of one perspective paper (accepted), Cancer and Aging study papers are under preparation.
  • Serve as a liaison to bridge communications between BGI and CGI Research team.
  • Co -manage "healthy individual baseline" project from BGI, provide technical and scientific consultations.
  • Serve as a focal point for external collaboration projects, such as Aging with Dr Richard Walker, Autism with Dr Dennis Wall (Stanford) etc.
09/2010 to 02/2012
Supervisor, Sequencing production team, OperationCompany Name - City, State
  • Responsible for achieving high First Pass Yield and fast Turn Around Time in Sequencing genomes.
  • Supervise a multi-shift group of 11 people from the production team. Manage and oversee over 14+ million dollar of Next Generation Sequencers.
  • Build strategic alliances with multiple supplier groups, schedule and manage the production flow that result in maximum genome delivery within current capacity.
  • Completed implementation of 5S lean six sigma in Sequencing facility and increased work efficiency by 100%.
  • Maintained up to date CLIA ready procedures and document controls in Sequencing facility. Continuously improving the team towards regulatory compliance, CLIA certification.
  • Lead and assist in transitions of new technology into an operation's environment from internal R&D groups.
  • Lead and assist continuous improvement efforts to improve quality, increase capacity, and reduce cost not only in Sequencing group but also in cross function teams.
  • Conduct 2 Six Sigma Black Belt projects in other cross functional areas to achieve operational excellence in production.
02/2008 to 08/2010
Physical Chemist, DevelopmentCompany Name - City, State
  • Responsible for optimizing massively-paralleled interaction between individual DNA biomolecules and nano-scale array to Complete Genomic's proprietary sequencing-probe chemistry and fluorescent detection.
  • Optimize the DNA-nanoarray interactions, develop SOPs that reduces the cost of the current process. Develop a robust process for scaling up next-generation sequencing process resulting in the first successful human genome sequencing on CGI's sequencer.
  • In authorship of a Science paper where demonstrates the first human genome sequencing on CGI's platform.
Education
2008
Post-doctoral scholar: Biophysics/BiochemistryStanford University

Investigated RNA structural change, in particular the formation of tetraloop-tetraloop receptor in RNA ribozymes using Small-Angle X-ray, single molecule FRET and structural visualization tools such as PyMOL

•Collected and analyzed data of RNA folding using small angle X-ray scattering at Argonne National Institute over three individual trips

•December 2007 “Bay Area All RNA meeting”, UCSF

•October 2006 “Biomedical computation at Stanford” BCATS, Stanford

•July 2006 “Workshop on Small-Angle X-ray Scattering and Diffraction Studies in Structural Biology” SLAC, Stanford

2006
Ph.D.: BiochemistryDundee University

Investigated electrostatic interactions and the folding of the four-way DNA junction by selective methyl phosphonate substitution, and the structural recognition upon binding to a resolving enzyme. Work resulted 5 publications

•Molecular structure of kink-turn motif in functional RNAs by Fluorescence Resonance Energy Transfer (FRET).

•Electrostatic interactions and the folding of the four-way DNA junction by selective methyl phosphonate substitution, and the structural recognition upon binding to a resolving enzyme using FRET, electrophoresis assay and structural visualization tools such as PyMOL.

2001
MS.c: Biological ChemistryDundee UniversityUK

Investigated anatomical and skeleto-muscular changes of chicken embryo development using Magnetic Resonance MicroImaging. Work resulted one publication.

2000
BS.c: Pharmaceutical ChemistryHubei Chinese Medicine and Medical University & Institute of Medical Materials - CityChina

Isolation and characterization of biologically active compounds from Gynostemma Pentaphyllum in the Cucurbitaceae family

Fellowships and Awards

2006-2008:Dean's Fellowship, Stanford University

2005: Howard Elder Prize, (annual best paper on cancer related study) Dundee University, UK.

2004: David Hutchinson Memorial Bursary Fund, RNA Structure and Function Conference, UK.

2003: David Hutchinson Memorial Bursary Fund, 5th Nucleic Acids Chemistry and Biology Cambridge Symposium, UK.

2001-2006 CRUK studentship, UK

2001 - 2005: Overseas Research Students Award, Dundee, UK

2000: International Student Award, Dundee, UK

Publications
1. You Y, Sun Y, Li X, Li Y, Wei X, et al. (2014) Integration of targeted sequencing and NIPT into clinical practice in a Chinese family with maple syrup urine disease. Genet Med 16: 594-600. 2. Chen S, Li S, Xie W, Li X, Zhang C, et al. (2014) Performance comparison between rapid sequencing platforms for ultra-low coverage sequencing strategy. PLoS One 9: e92192. 3. Peters BA, Kermani BG, Sparks AB, Alferov O, Hong P, et al. (2012) Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells. Nature 487: 190-195. 4. Drmanac R, Sparks AB, Callow MJ, Halpern AL, Burns NL, et al. (2009) Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science 327: 78-81. 5. Liu J, Lilley DM (2007) The role of specific 2'-hydroxyl groups in the stabilization of the folded conformation of kink-turn RNA. RNA 13: 200-210. 6. Li X, Liu J, Davey M, Duce S, Jaberi N, et al. (2007) Micro-magnetic resonance imaging of avian embryos. J Anat 211: 798-809. 7. Liu J, Declais AC, Lilley DM (2006) Mechanistic aspects of the DNA junction-resolving enzyme T7 endonuclease I. Biochemistry 45: 3934-3942. 8. Declais AC, Liu J, Freeman AD, Lilley DM (2006) Structural recognition between a four-way DNA junction and a resolving enzyme. J Mol Biol 359: 1261-1276. 9. Liu J, Declais AC, McKinney SA, Ha T, Norman DG, et al. (2005) Stereospecific effects determine the structure of a four-way DNA junction. Chem Biol 12: 217-228. 10. Liu J, Declais AC, Lilley DM (2004) Electrostatic interactions and the folding of the four-way DNA junction: analysis by selective methyl phosphonate substitution. J Mol Biol 343: 851-864.
Highlights

familiar with biomedical start-up environment; continuous improvement; project/product management; critical and creative thinker; results-oriented problem solver; effective communicator

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Resume Overview

School Attended

  • Stanford University
  • Dundee University
  • Hubei Chinese Medicine and Medical University & Institute of Medical Materials

Job Titles Held:

  • Manager, R&D project management, Research
  • Supervisor, Sequencing production team, Operation
  • Physical Chemist, Development

Degrees

  • Post-doctoral scholar : Biophysics/Biochemistry
    Ph.D. : Biochemistry
    MS.c : Biological Chemistry
    BS.c : Pharmaceutical Chemistry

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