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Chief Scientific Officer Resume Example

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CHIEF SCIENTIFIC OFFICER
Professional Summary

Effective senior scientist with 19 years of laboratory experience in biotechnology with emphasis on molecular biology assay development, co-inventor on 4 telomerase patents, and influential track record investigating telomere biology and age-related disease. Responsible for spearheading a successfully redesigned drug discovery operation leading to the discovery of telomerase activators TAM-818 and IsaGenesis® while boosting company revenue over $1.5 million. Goal-oriented leader who encourages employees to deliver results in a professional, organized, productive manner. Seeking senior scientist position in molecular biology, or related field, to execute exciting research with fresh challenges.

Skills
  • Molecular biology
  • Quantitative PCR
  • RNA/DNA extraction & quantification
  • Gene editing
  • Plasmid construction
  • DNA sequence analysis
  • AAV gene therapy
  • Teamwork/Collaboration
  • Project Management
  • Relationship building and retention
Work History
Chief Scientific Officer, 08/2008 to Current
Sierra Sciences – Reno, NV

Lead science operations by driving development of novel therapies for aging-related disease in humans using small-molecule drug discovery, nutraceutical development, and gene therapy while mobilizing efforts to incorporate new technologies (RNAseq, CRISPR, NanoString) into telomerase research. Actively collaborating with medical professionals in drafting clinical protocols for AAV hTERT gene therapy to treat Alzheimer's, Cardiomyopathy, Critical Limb Ischemia, and Idiopathic Pulmonary Fibrosis while building business partnerships with Libella Gene Therapeutics and DefyTime.

  • Strengthen intellectual property by contributing to AAV gene therapy patents.
  • Optimize laboratory processes to operate more efficiently.
  • Resolve budget concerns by decreasing expenditures by 25% to maintain current workforce.
  • Capitalize on untapped market by developing age-reversal products for pets.
  • Customize baculovirus-AAV vectors to reduce immune response.
  • Motivate Chief Executive Officer with valuable data and aggressive timelines.
Director High-Throughput Drug Screening, 08/2008 to 02/2016
Sierra Sciences – Reno, NV

Developed multiplexed cell-based qRT-PCR high-throughput drug screening assay to detect hTERT mRNA and reference gene expression in normal human somatic cells down to 0.005 mRNA copies/cell, utilizing magnetic oligo(dT) beads in 96-well format RNA isolations, and CellTiter-Glo Luminescent Cell Viability assays of lysate aliquots in tandem. This robust assay served as driving force for redesigning drug discovery operations to screen 10,000+ compounds per week with established quality control practices.

  • Managed 20+ employees on multi-disciplinary team to screen 300,000+ small-molecules, identifying >1700 novel telomerase activating small-molecules covering 30 unique structure classes leading to discovery of TAM-818 and IsaGenesis® months ahead of schedule using Biomek FX, LightCycler 480, and Envision hardware.
  • Trained 3-6 employees per week in all areas of drug discovery (sample process tracking, liquid handling, reagent management, and lab instrument operation).
  • Built data management files/templates to streamline analytics.
  • Facilitated communication by conducting weekly meetings with team members; providing weekly screening reports for internal/external stakeholders.
  • Guided IT department to reinforce documentation of scientific processes.
  • Boosted drug efficacy by providing valuable data to design 400 custom small molecules based on structure activity relationships of lead compounds.
  • Fostered partnership with collaborating scientist as co-inventor on patent for nutritional activation of telomerase.
Scientist, 05/2005 to 08/2008
Sierra Sciences – Reno, NV

Executed 3 research projects over 3 years in molecular biology, protein chemistry, and assay development to discover transcription factor(s) responsible for repressing hTERT gene expression in normal human somatic cells.

  • Mapped hundreds of mutations in telomerase promoter using site-directed mutagenesis, DNA sequencing analysis, and plasmid reporter assays to identify novel repressor binding sites.
  • Discovered transcription factor LSF binding to putative repressor DNA binding site in hTERT promoter using Fast Protein Liquid Chromatography (FPLC), Electro-Mobility Shift Assays (EMSAs), and GC-MS.
  • Implemented RNAi (siRNA, lentiviral shRNA vectors) to knock-down expression of candidate hTERT repressor proteins in-vitro.
  • Co-invented drug-screening assay using mutant RNA component of telomerase.
  • Organized research data to create representative graphs to highlight results for presentations.
Research Associate, 05/2003 to 05/2005
Sierra Sciences – Reno, NV

Recognized by leadership as best employee in molecular biology with unparalleled efficiency, completing complex plasmid construction projects while generating 3,000+ plasmids to characterize the hTERT minimal promoter months ahead of schedule.

  • Established skillsets (site-directed mutagenesis, RNA/DNA extractions, plasmid construction, plasmid purification, gel electrophoresis, and assay development).
Education
Master of Science: BiotechnologyUniversity of Nevada - Reno, NV
Patents

Andrews, William H.; Brown, Lancer K.; Mohommadpour, Hamid; Briggs, Laura A. “Enhancing health in mammals using telomerase reverse transcriptase gene therapy.” US Patent Number: 10,485,852. Date: November 26, 2019.

Andrews, William H.; Brown, Lancer K.; Mohommadpour, Hamid; Briggs, Laura A. “Enhancing health in mammals using telomerase reverse transcriptase gene therapy.” US Patent Number: 9,453,209. Date: September 27, 2016.

Fahy, Gregory M.; Brown, Lancer. “Nutritional activation of telomerase in-vitro with increased safety.” US Patent Number: 8,815,899. Filed on August 26, 2014.

Andrews, William H.; Briggs, Laura A; Brown, Lancer K.; Foster, Christopher A.; Piatyszek, Mieczyslaw A. "Assays for TERT promoter modulatory agents using a telomerase structural RNA component." US Patent Number: 7,226,744. Date: June 5, 2007.

Publications

Coussens, M., Davy, P., Brown, L., Foster, C., Andrews, W.H., Nagata, M., Allsopp, R. (2010) RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1a as critical for telomerase function in murine embryonic stem cells. PNAS 107(31): 13842-7.

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Resume Overview

Companies Worked For:

  • Sierra Sciences

School Attended

  • University of Nevada

Job Titles Held:

  • Chief Scientific Officer
  • Director High-Throughput Drug Screening
  • Scientist
  • Research Associate

Degrees

  • Master of Science : Biotechnology

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