Senior Research Scientist, PhD.
New York University School of Medicine
New York, NY 10016, USA.
I have successfully shifted my studies from the agricultural field to the medical field after I got my PhD in 2000. Because I am very interested in cancer research, I have continued working in that area for more than 15 years. My research focus is on prostate cancer. Through these many years of research experience, I have developed an excellent proficiency in cancer research with broad scopes of both in vitro and in vivo, from cell cultures to animal models. My strongest skills include adapting, developing, and troubleshooting. For a new or tough project, I am able to figure out the key issue by searching the references and analyzing critically. This way, I can tackle the problems and work out the best possible solutions. That is why I may forge ahead in the field of cancer research even when it was not my original expertise.
Since I moved to NYU from WFU, I have been working on patient specimen for immunoprofiling, PDOTs(patient-derived organotypic tumor spheroids) isolation and drug treatment. I have grasped more specific techniques for clinical specimen processing and analysis. I has successfully developed syngeneic mouse organoid model for prostate cancer preclinical study. Also I am involved in lung cancer mouse models, thus enriched much more expereince(dosing, MRI, sample collection, etc) for preclinical studies.
1. Prostate and lung cancer patient specimen: processing, PDOTs
culture and drug treatment and efficacy analysis, Immunoprofiling
2. Preclinical study: lung cancer mouse model： breeding, dosing, adenovirus
nasal induction, ultrasound guiding thoracic tumor cell injection. MRI and quantification.
3. Prostate cancer modeling: Organoids isolation from cas9 mice and GEMM mice prostate, tumor suppression gene manipulation(CAS9/CRISPR) and Myc overexpression, Allograft implantation, tumor imaging (MRI, ultrasound and Bioluminescence)
4. MDOTs(murine-derived organotypic tumor spheroids) - drug treatment and immunoprofiling
5. Lab management: paper work(animal IACUC protocol,IBC), ordering
*Wu, J.S, et.al Syngeneic Mouse Prostate Cancer Organoid Models for Preclinical Study(Drafted).
*Fable's, V.R.A., Ahsan, A and Wu, J.S , et.al High-Risk Localized Prostate Cancers Harbor a Distinct Immunosuppressive Profile Characterized by Increased Regulatory T cells and PD-L1-expressing Myeloid Cells (submitted to Prostate Cancer and Prostatic Diseases).
*Fable's, V.R.A., Adeegbe, D., Ahsan, A., Wu, J.S. et al High-risk localized prostate cancer harbors a distinct immunosuppressive milieu. 2020 Genitourinary Cancers Symposium Meeting (February 13-15, 2020).
*Suburu, J., Shi, L.H., Wu, J.S, Wang, S.H., Samuel, M., Thomas, M.J., Kock, N.D., Yang, G.Y., Kridel, S., and Chen, Y.Q. Fatty acid synthase is required for mammary gland development and milk production during lactation. Am J Physiol Endocrinal Metab 2014 306:E1132-E1143.
*Gu, Z.N., Wu, J.S, Wang,S.H., Suburu, J., Chen, H.Q., Thomas, M.J., Shi, L.H., Edwards,I.J, Berquin, I.M., Chen, Y.Q. Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells 2013 Carcinogenesis 2013 34(9):1968-1975
*Wang, S.H., Wu, J.S, Suburu, J., Gu, Z.N., Cai, J., Axanova, L.S., Cramer, S.D., Thomas, M.J., Perry, D.L., Edwards, I.J., Mucci, L.A., Loda, M.F., Sui, G.C., Berquin, I.M., Chen, Y.Q. Effect of dietary polyunsaturated fatty acids on castrationresistant prostate cancer Carcinogenesis. 2012 Feb;33(2):404-12
*Wang, L, Chen, W, Feng, Y, Ren Y, Gu, Z, Chen, H, Wang, H, Thomas, M.J., Zhang, B., Berquin, I.M., Li, Y., Wu, J.S. , Zhang, H., Song, Y., Liu, X., Norris, J.S., Wang, S., Du, P., Shen, J., Wang, N., Yang, Y., Wang, W., Feng, L., Ratledge, C., Zhang, H., Chen, Y.Q. Genome characterization of the oleaginous fungus Mortierella alpina. PLoS One. 2011;6(12):e28319.
*Hu, Y.P, Sun, H.G, Owens, R.T, Gu Z.N., Wu, J.S., Chen, Y.Q., O'Flaherty J.T., Edwards, I.J.. Syndecan-1-dependent suppression of PDK1/Akt/Bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia. 2010 Oct;12(10):826-36.
*Hu, Y.P, Sun, H.G, Owens, R.T, Wu, J.S., Chen , Y.Q., Berquin, I.M., Perry, D.L O'Flaherty J.T., Edwards, I.J. Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways. Neoplasia. 2009 Oct;11(10):1042-53.
*Berquin, I.M., Min, Y.N., Wu, R.P., Wu, J.S., Perry, D., Cline, J.M., Thomas, M.J., Thornburg, T., Kulik, G., Smith, A., Edwards, I.J., D'Agostino, R., Zhang ,H., Wu ,H., Kang, J.X., Chen, Y.Q. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. Journal of Clinical Investigation 2007 Jul;117(7):1866-75.
*Hu, S.J., Wu, J.S., Burkey, K.O., Firestone, M.K. Plant and microbial N acquisition under elevated atmospheric CO2 in two mesocosm experiments with annual grasses. Global Change Biology 2005 11( 2) : 213-223
*Zhang, W.J., Feng, J.X., Wu, J.S., Parker, K. Differences in soil microbial biomass and activity for six agroecosystems with a management disturbance gradient. Pedosphere 2004 14(4): 441-447.
*Wu, J.S., Lu, X.Z., Shao, M., Wang, J.S. A bacterium possessing biological activity against toxins in organic acids produced by phytopathogen. Journal of Southwest Agricultural University.2000 22 (3): 222-225. (This paper was abstracted in the CAB international 2000/08-2001/10)
*Wu, J.S., Wang J.S. Control effect of W-1 with detoxification activity activity against Scleotinia sclerotiorum and its primary identification Journal of Southwest Agricultural University 2000 22(6):487-489.
*Wang J.S., Wu, J.S, Song C.F and Liu F.Q. 2000. Phytopathogenic Bacteriology. China Agriculture Press(Book)
*Zhu, Y.L., Wu J.S., Wang, J.S. Analysis of resistance-related proteins in rice against Xanthomonas oryzae pv.oryzae by two-dimensional electrophoresis Scientia Agricultura Sinica 2000 33(4): 91-93. (This paper was abstracted in the CAB international 1996-1998/07)
*Wu, J.S., Liang, J.D., Wang, J.S. Effects of Echcin on control of crop fungal and bacterial diseases. Acta Phytopathologica Sinica. 1999 29:104-109. (This paper was abstracted in the CAB international 1998/08-2000/07)
*Li, H.Y., Wu, J.S, Song, C.F. and Wang, J.S. Hypersensitive reaction in the interaction between rice IR26 cell suspension and Xanthomonas oryzae pv. oryzae Acta Phytopathologica Sinica. 1999 29(4):299-303.(This paper was abstracted in the CAB international 1998/08-2000/07)
*Ouyang, P.K., Zhang, G..D., Wu, J.S., Wang, J.S., Zhang, L.Y., Li, G.F. 1999. Handbook of Chemical Industrial Products. Chemical Industry Press(Book).
*Wu, J.S. , Wang, J.S. Changes in soluble proteins in rice leaves in the interaction between rice and bacterial blight (Xanthomonas oryzae pv. oryzae). Journal of Southwest Agricultural University 1998 20(4): 321-327. (This paper was abstracted in the CAB international 1998/08-2000/07)
*Yang, Z. C., Wu, J.S.1998. Screening of biocontrol microorganism against two wheat diseases. Chinese Journal of Microecology(supplement)10: 61-64.
*Zhu, Y.L., Wu, J.S. Wang, J.S. A preliminary study on the expression of defense genes in rice-suspension induced by Xanthomonas oryzae pv.oryzae. Acta Phytopathologica Sinica 1997 29: 250. (This paper was abstracted in the CAB international 1996-1998/07)
*Wu, J.S., Dong, C., Leng, F.F. Wang, J.S. Induced resistance of the incompatible race of Xanthomonas oryzae pv.oryzae to rice and preliminary study of PR-proteins. Acta Phytopathologica Sinica 1996 26(2):110. (This paper was abstracted in the CAB international 1996-1998/07) *Wu, J.S., Wang, J.S. The bacteriocin from the phytopathogenic bacteria 1996 Microbiology 23:95-101.
*Liu, H.L., Zhang, X.Z, Wang, J.S. Wu, J.S..Purification and characterization of antifungal protein of B3(Bacillus subtilis) Journal of Agricultural biotechnology 1995 26:33-38.
*Caner Biology Honor, Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA (2011).
*Science and Technology Advance Award, Jiangsu Province Science and Technology Committee, Jiangsu Province, P.R.China (1999).
*Excellent Research Paper Award, Nanjing Agricultural University, Jiangsu Province, P.R.China (1997).
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