SEARCH

Research Scientist I, (Compound Management, Lead Discovery & Optimization) Resume Example

Resume Score: 100%

Love this resume?Build Your Own Now
RESEARCH SCIENTIST I, (COMPOUND MANAGEMENT, LEAD DISCOVERY & OPTIMIZATION)
Professional Overview

Motivated Research Scientist with over 18 years experience in compound management. Adept at laboratory management and extensively trained on multiple liquid handling platforms.

Core Qualifications
  • Experience with the distribution of both wet and dry compounds
  • Advanced knowledge of liquid handling automation (Agilent,Tecan & Labcyte)
  • Advanced knowledge of storage and retrieval systems
  • Quality assurance and control
  • Process improvement
  • Detail Oriented
  • Superb time management skills
  • Experience with various LIMS systems
  • Experience with Microsoft Office (Word,Excel,Outlook,PowerPoint)
Experience
Research Scientist I, (Compound Management, Lead Discovery & Optimization)
July 2011 to CurrentBristol-Myers Squibb － Wallingford, CT
  • Managed DMSO stock compound collection and all incoming sample plating requests; supporting all early discovery research
  • Managed resource allocation of staff and automation resources supporting all wet compound plating activities
  • Served as primary point of contact for HTS
  • Member of core leadership team responsible for the creation of functional specification documentation defining all compound handling requirements, which facilitated the development and integration of a highly flexible automated wet compound sample plating and replication platform
  • Developed the training protocols and supporting documentation encompassing all wet compound sample handling processes utilized by Compound Management colleagues
  • Generated process mappings and gap analysis of current wet plating processes in preparation for migration to new LIMS system (Mosaic)
  • Writing and executing detailed test scripts for all wet plating processes related to changing of internal inventory software
Associate Research Scientist II
July 2007 to July 2011Bristol-Myers Squibb － Wallingford, CT
  • Established methods on the Biocel and tested all necessary informatics to allow the transfer of over 1.2 MM compounds from the Haystack Tube Store to the new HomeBase tube Store
  • Developed and tested liquid handling methods for the implementation of direct 96 to 1536 plating, which reduced our compound consumption for retests by 50%
  • Developed and tested Agilent Biocel methods and assisted in testing informatics for the integration of a large acquisition of compounds.This resulted in 1MM new samples being introduced into the screening deck
  • Assisted with the implementation of the new Inbound and Shipping application. This streamlined the process of receiving as well as shipping out samples to our other BMS sites.
  • Between 2008-2009 distributed over 30k plates and replicated over 30MM wells to Lead Discovery
  • Collaborated with other members of the team to establish a method for the creation of concentration response curve ready plates (CRC) directly from tubes to 1536 well plates. This resulted in over an 80% reduction in compound consumption for this process.
  • Created 1536 well mother plates (over 500k compounds) for initial load of HTS plate store
  • Migrated all wet plating processes from old Tecan Genesis platform to new Tecan Evo

Associate Research Scientist I
July 2003 to July 2007Bristol-Myers Squibb － Wallingford, CT
  • Managed plating systems used for the preparation and distribution of all assay ready plates with an average yearly distribution exceeding 10 million wells per year
  • Inventory conversion project which included the retrieval, reformatting and loading of over 1,000,000 wet compounds into our new TAP HomeBase tube store
  • Drove natural products project which required reformatting 13,000 natural products extracts into plates for Oncology screening.
  • Weekly QC of all liquid handling instruments
  • Reporting of monthly metrics.
  • Distributed over 30k plates and replicated over 30MM wells to Lead Discovery
  • Processed ~50k compounds (in 1 month) for external collaboration
Assistant Research Scientist II
January 1997 to July 2003Bristol-Myers Squibb － Wallingford, CT
  • Collaborated with BMS engineers to design, develop and implement a custom fully automated microtube capping and decapping station.This significantly increased throughput and allowed increased walk away time for the end user. Prior to this the process was time consuming and labor intensive
  • Responsible for the preparation, storage, and distribution of wet plates
  • Verified that all inventory files and platemaps were accurate and available to the screening community
  • Improved the efficiency of plate replication through the evaluation and integration of new forms of liquid handling automation.
  • Preparation of daily shipments to other sites
  • Became experienced user of Haystack Automated Tube store
  • Proficient in the use of Tecan, Zymark, Hamilton and Velocity 11 automation
  • Capable of developing liquid handler methods, troubleshooting and basic maintenance
Awards
  • R&D Star Award for "Compound Management Cherry Pick Process Optimization", 2014
  • R&D Star Award for "Regression testing effort during server upgrade project", 2013
  • R&D Star Award for "Supplying over 20k compounds for two external technology evaluations", 2011
  • R&D Star Award for providing 28k compounds to Virology while concurrently plating an additional 47k compound for HTS in 1 month, 2011
  • R&D Star Award for "Providing retests in a timely manner and helping achieve our "screen in a week" campaign, 2009
  • Triumph Team Award for contributions to the "HTS Miniaturization Initiative", 2008
  • R&D Star Award for "Initial load of Homebase tube store", 2007
  • R&D Star Award for "Management of Tube Store and Assay Ready Plating", 2005
  • R&D Star Award for "Natural Products Reformat for Oncology Screening", 2003
Publications

Technical Note:

John E. Leet, James V. Belcastro, Craig J. Dowling (2015). HPLC Biogram Analysis: A Powerful Tool Used for Hit Confirmation in Early Drug Discovery, Journal of Biomolecular Screening, June 2015

Skills
  • Advanced knowledge of multiple LIMS systems, specifically OSCAR (The Automation Partnership) and Mosaic (Titian)
  • Experience with liquid handling automation (Tecan, Agilent BioCel , Agilent BenchCel and Labcyte Echo)
  • Knowledge of liquid handling software Tecan Genesis & Evoware, Agilent Vworks and BenchWorks
  • Strong verbal and written communication skills
  • Process development and optimization
  • Metrics analysis and reporting
Education
Bachelor of Science : 1996Teikyo Post University
Build Your Own Now

DISCLAIMER

Resumes, and other information uploaded or provided by the user, are considered User Content governed by our Terms & Conditions. As such, it is not owned by us, and it is the user who retains ownership over such content.

Resume Overview

Companies Worked For:

  • Bristol-Myers Squibb

School Attended

  • Teikyo Post University

Job Titles Held:

  • Research Scientist I, (Compound Management, Lead Discovery & Optimization)
  • Associate Research Scientist II
  • Associate Research Scientist I
  • Assistant Research Scientist II

Degrees

  • Bachelor of Science : 1996

Similar Resumes

View All
Research-Scientist-I,-Technical-Director-CACF-resume-sample

Research Scientist I, Technical Director CACF

Tulane University Cancer Center

Metairie, Louisiana