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RESEARCH INVESTIGATOR
Profile
Expert in sweetness perception, modulation and use of flavors to improve the overall taste of non-caloric sweeteners Expert in converting research results into profitable innovation Discovered, developed and commercialized globally four ingredients that dramatically improve the organoleptic profile of non-caloric sweeteners Generated strong natural ingredient pipelines for optimizing that taste of non-caloric sweeteners; currently in various phases of development/commercialization Thorough understanding of physico-chemical properties, structure-activity relationships, toxicology. Working experience with navigating the regulatory landscape. Developed holistic approaches for sweetness modulation Intellectual Property strategy Seasoned project leader of complex research project involving cross-functional, multi-cultural teams Twelve years of research and project management experience in the area of taste modulation focusing on sweet and bitterness masking
Areas of Expertise
  • A1 20130523
  • Flamme, Eric; Ungureanu, Ioana Maria; Kohlen, Eric Para-*alkoxy benzonitrile compounds as sweetness enhancers PCT Int. Appl. (2011), WO 2011032967 A1 20110324
  • Ungureanu, Ioana M.; Yap, Amy H.; Machover, Sarah; Bom, David; Kohlen, Eric; Daniher, Andrew T.; Christenson, Phil A.; Slack, Jay P.; Odley, Amy; Augelli, Jenifer; et al. Discovery of a new generation of highly potent bitterness blockers Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), AGFD-66
  • Ungureanu, Ioana Maria; Van Ommeren, Esther Off-*taste masking sweetener PCT Int. Appl. (2010), WO 2010100158 A1 20100910
  • Slack, Jay P.; Brockhoff, Anne; Batram, Claudia; Menzel, Susann; Sonnabend, Caroline; Born, Stephan; Galindo, Maria Mercedes; Kohl, Susann; Thalmann, Sophie; Ostopovici-Halip, Liliana; et al Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist Current Biology (2010), 20(12), 1104-1109
  • Ungureanu, Ioana M.; Yap, Amy H.; Machover, Sarah; Daniher, Andrew T.; Christenson, Phil A.; Slack, Jay P.; Brune, Nicole E.; Odley, Amy; Furrer, Stefan M.; Bell, Karen A.; van Ommeren, Esther; Gray, Kimberley; Ostopovici-Halip, Liliana; Bologa, Cristian G.; Oprea, Tudor I. Discovery, synthesis and SAR of
Professional Experience
Givaudan flavors S+T January 2012 to Current Research Investigator
  • Subject matter expert in the area of sweeteners and sweet taste modulation, taste improvement of non-caloric sweeteners as well as improving the taste of low-sugar/mid-cal applications.
  • Generated a robust, revolutionary ingredient pipeline for sweetness improvement currently being evaluated for commercialization.
  • Successfully managed research projects in the area of sweet taste modulation coordinating cross-functional teams of more than forty people, from basic research all the way through commercialization of new ingredients with global reach.
  • Coordinated work with external scouting companies and research groups to identify new partners for open innovation with Givaudan Flavors S+T.
  • Successfully insured transition from proof-of-the-principle stage to long-term collaborations.
Givaudan flavors R&D January 2008 to January 2012 Senior Research Scientist
  • Lead cross-functional team to identifying new opportunities in the sweet taste innovation and bitterness blocking program with emphasis on developing successful new natural ingredients.
  • Dynamically aligned research team goals with rapidly changing business needs.
  • Developed the Givaudan Flavors natural screening library through external purchases as well as internal fractionation work.
  • Optimized fractionation methods to adapt resulting libraries to the requirements of High Throughput Screening technologies.
  • Developed innovative selection rules for natural, "taste friendly" compounds to radically improve research focus on business relevant natural space.
Givaudan flavors R&D January 2003 to January 2008 Research Scientist II
  • Discovered, developed and commercialized GIV3727, a unique bitterness blocker.
  • Coordinated the regulatory approval, IP strategy, commercialization and roll-out to the regions.
  • Leader of the bitterness blocking project, coordinated a large team (over 120 people) across the Flavor and Fragrance divisions.
  • Breakthrough work on selection rules for commercial candidates for taste modulation based on High Throughput Screening assays.
  • Implemented state-of-the-art research methodologies from the pharmaceutical industry.
  • Pioneered the design and implementation of effective filters to select screening libraries for High Throughput Screening (Collaboration with Pr.
  • Tudor Oprea and Dr.
  • Cristian Bologa).
Education
State University of New York University Louis Pasteur 2003 PhD: Organic Chemistry Stony Brook Strasbourg, France GPA: with highest honors Organic Chemistry with highest honors
University Louis Pasteur 1998 MSc: Pharmacology and Pharmacochemistry Strasbourg, France Pharmacology and Pharmacochemistry
University Paris V Rene Descartes 1997 MSc: Organic and Bio-organic Chemistry Paris, France Organic and Bio-organic Chemistry
Student, Ecole Normale Superieure 1998 Paris, France the first commercially successful bitterness blocker identified using receptor-based technologies. Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 MEDI-569 Ungureanu, Ioana Maria; Brune, Nicole Erna Irene; Slack, Jay Patrick; Gray, Kimberley; Simons, Christopher Todd; Evans Pennimpede, Jenny Ellen. Blockers of off-notes in sweeteners or other consumables. PCT Int. Appl. (2009), 24pp. WO 2009015504 A2 20090205 Brune, Nicole Erna Irene; Slack, Jay Patrick; Ungureanu, Ioana Maria; Gray, Kimberley; Simons, Christopher Todd; Evans Pennimpede, Jenny Ellen. Methods using cells expressing type 2 bitter taste receptors to identify modulators of bitter taste of sucralose. PCT Int. Appl. (2008), 63pp. WO 2008119195 A1 20081009 Ungureanu, Ioana Maria; Brune, Nicole Erna Irene; Slack, Jay Patrick; Gray, Kimberley; Simons, Christopher Todd; Evans Pennimpede, Jenny Ellen. Preparation of alicyclic compounds as off-note masking agent in consumables. PCT Int. Appl. (2008), 36pp. WO 2008119196 A1 20081009 Ungureanu, Ioana Maria; Brune, Nicole Erna Irene; Simons, Christopher Todd; Gray, Kimberley; Slack, Jay Patrick. 4-(2, 2, 3-TRIMETHYLCYCLOPENTYL) BUTANOIC ACID USED AS AN OFF-NOTE MASKING AGENT IN CONSUMABLES. PCT Int. Appl. (2008), 26pp. WO 2008119197 A1 20081009
Languages
Romanian (native), English (fluent), French (fluent), German, Italian, Spanish (basic notions)
Skills
ACID, art, basic, Biology, CA, English, focus, French, functional, German, innovation, IP, Italian, notes, pp, natural, optimization, posters, presentations, Pr, PCT, publications, research, Romanian, San, Spanish, strategy, team management, type 2, unique
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Resume Overview

Companies Worked For:

  • Givaudan flavors S+T
  • Givaudan flavors R&D

School Attended

  • State University of New York University Louis Pasteur
  • University Louis Pasteur
  • University Paris V Rene Descartes
  • Student, Ecole Normale Superieure

Job Titles Held:

  • Research Investigator
  • Senior Research Scientist
  • Research Scientist II

Degrees

  • PhD : Organic Chemistry
    MSc : Pharmacology and Pharmacochemistry
    MSc : Organic and Bio-organic Chemistry

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