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Post-doctoral Researcher Resume Example

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POST-DOCTORAL RESEARCHER
Summary

A dynamic, motivated, and reliable scientist with an outstanding publication record. Proficient in mammalian cell culture, cellular, molecular assays and genetic as well as chemical perturbation screens. In the leading edge of the oncology field applying the latest techniques to define, validate, and understand molecular targets for drug discovery for the past 5 years.

Skills
  • Cellular Biology
  • Molecular Biology
  • Biochemistry
  • Bioinformatics
  • Cell Culture
  • Assay Development
  • In Vivo Pharmacology
  • Knockdown and Knockout
  • Mice xenografts
  • Drug Discovery
Experience
Post-doctoral Researcher - University Of Pennsylvania (Philadelphia, Pennsylvania)August 2016 - Current
  • Generated stable cell lines and genetically engineered human cancer cells
  • Investigated gene composition and mechanisms after knockdown and knockout
  • Maintained different normal and cancer lines in cell culture
  • Develop a broad array of cellular imaging and assays
  • Worked with data analytics platforms and computational biology tools
  • Performed angiogenesis and xenografts mice models
  • Trained in bioinformatics basic-level
  • Performed in vivo pharmacology (mice and rabbits) using IVIS Lumina system
  • Executed many antibody-based assays as WB, ELISA, IP, IHC and IF analyses
  • Developed reports, posters, presentations and manuscripts in different languages.
  • Mentored four Penn undergrads, one Penn medical student, one cancer biology PhD candidate and one technician
  • Worked collaboratively with a team of scientists and technology vendors
  • Presented at lab meetings and at department seminars
Post-doctoral Researcher - Federal University Of Parana (Curitiba, Brazil)January 2014 - July 2016
  • Cloned, expressed, and purified drug targets
  • Produced specific new drug targets antibodies
  • Validated novel drug targets
  • Embarked on molecular phenotypic profiling for drug discovery
  • Performed thermodynamic analysis of inhibitors and drug targets
  • Applied in vitro cell-based assays to characterized specific inhibitors
  • Performed in vivo pharmacology assays
  • Evaluated the hemolytic, dermonecrotic, and inflammatory activity of recombinant molecular targets
  • Mentored students to execute assigned tasks with validity
  • Obtained and reviewed data and information from scientific publications and literature.
  • Documented and published articles in professional publications and scientific journals such as Journal od Cellular Biochemistry.
Post-doctoral Researcher - Johns Hopkins University (Baltimore, Maryland)November 2011 - November 2013
  • Cloned, expressed, and purified the drug target PiK3 for oncology drug discovery
  • Investigated the mutated Pi3k signaling pathway in cancer cells
  • Grew in large-scale insect cells in a bioreactor for the production of human recombinant targets
  • Reported two new crystal structures of Pi3K, and its implications for drug design
  • Performed thermodynamic analysis of new Pi3K inhibitors
  • Executed fluorescence cell-based assays
  • Worked collaboratively with other research staff
  • Trained and supervised three JHU undergrads
  • Documented and published articles in professional publications and scientific journals such as Oncotarget.
Education and Training
PhD in Molecular And Cell BiologyJanuary 2012Federal University of Parana, Curitiba - Brazil
  • Summa cum laude graduate
  • Completed coursework in Advanced Seminars in Cell and Molecular Biology, Advanced Immunology, Advanced Biochemistry, Cancer Biology, Structural Biology, Protein Purification Methods, Intracellular Signaling, Extracellular Matrix, Genomic and Transcriptomic Analysis, Computational Biology and Bioinformatics, Teaching Training 2, and Practice in Teaching
  • Thesis: Biochemical and Biological Characterization of Phospholipases present in the venom of Loxosceles intermedia and Lonomia obliqua
  • National Council for Scientific and Technological Development Scholarship Recipient
  • SBBq Poster Award Recipient
  • Brazilian Society of Biochemistry and Molecular Biology Member
  • Published six scientific manuscripts in high-impact journals
Masters in Molecular And Cell BiologyAugust 2008Federal University of Parana, Curitiba - Brazil
  • Summa cum laude graduate
  • Completed coursework in Cell Biology, Basics of Molecular Biology, Cell Culture, Purification, Characterization and Engineering of Proteins, Basic Techniques in Microscopy, Molecular Methods Used in Cell Biology for Protein Study, Immunochemistry and Immunofluorescence, Bioethics and Good Laboratory Practices, Seminars 1, and Teaching Training 1
  • Dissertation: Study of the hemolytic activity of the Loxoscelesintermedia (Brown recluse Spider) venom and its molecular mechanisms
  • National Council for Scientific and Technological Development Scholarship Recipient
  • SBBq Poster Award Recipient
  • Published two scientific manuscripts in high-impact journals
PharmD in Pharmaceutical SciencesMarch 2007Federal University of Parana, Curitiba - Brazil
  • Magna cum laude graduate
  • Ranked in Top 1% of a highly competitive class
  • Cellular and Molecular Biology
  • Biochemistry
  • Histology
  • Medicinal Chemistry
  • Pharmacology
Activities and Honors
  • American Association for Cancer Research Scholar Award
  • Takeda Oncology Scholar-in-Training Award
  • Ann and Sol Schreiber Mentored Investigator Award
  • Member of the MDPI Publishing Review Committee
  • Member of the American Association for Cancer Research
  • Co-Chair of the BPC Career Enhancement and Training Committee
  • Student representative on the board of the UPFR Molecular and Cell biology department
Mentoring

2020 - Present Adam Ferrari (University of Pennsylvania PhD candidate)

2019 - 2019. Alvin Sanches ((University of Pennsylvania Techician)

2019 - 2020 Sara Hobday (University of Pennsylvania medical student)

2016 - 2018 Cristina Arruza (University of Pennsylvania undergraduate student)

2016 - 2018 Andrea Klein (University of Pennsylvania undergraduate student)

2014 - 2016 Diogo de Lima (Federal University of Parana undergraduate student)

2014 - 2016 Emerson Spaki (Federal University of Parana undergraduate student)

2014 - 2016 Paulo Pallozi (Federal University of Parana undergraduate student)

2012 - 2013 Willian Hong (Johns Hopkins University undergraduate student)

2012 - 2013 Lucy Gao (Johns Hopkins University undergraduate student)

Teaching

2014 - 2016 Molecular and Cell Biology, Pharmacy School, University Federal of Parana

2014 - 2016 Human Histology, Pharmacy School, University Federal of Parana

Languages
Portuguese (Native), Spanish (Fluent), English (fluent) and French (Basic).
Websites, Portfolios, Profiles
  • https://www.researchgate.net/profile/Daniele_Chaves-Moreira
  • https://orcid.org/0000-0001-6562-8817
Publications

Book Chapters

1. Chaves-MoreiraD, Trevisan-Silva D, Gremski LH, Veiga SS. Venom Genomics and Proteomics 10.1007/978-94-007-6649-5_28-1 ed. Gopalakrishnakone P, Calvete JJ, editors. Springer Science+Business Media Dordrecht: Springer Netherlands; 2014. Brown Spider Venom: The Identification and Biotechnological Potential of Venom Toxins; p.1-20.

Research Articles

1.Chaves-Moreira D, Mitchell MA, Brady D, Sidoli S, Garcia B, Morin PJ and Drapkin R. PAX8 orchestrates an angiogenic program through interaction with SOX17. Cancer Cell , 2020.

2.Chaves-Moreira D, Morin PJ and Drapkin R. Unraveling the mysteries of PAX8 in the reproductive system. Cancer Reserach, 2020.

3. Reddy J, Fonseca MAS, Corona RI, Nameki R, Dezem FS, Klein IA, Chang H, Chaves-Moreira D, Afeyan L, Malta TM, Lin X, Abbasi F, Font-Tello A, Sabedot T, Cejas P, Rodríguez-Malavé N, Seo J, Lin D, Matulonis U, Karlan B, Gayther. SA, Gusev A, Noushmehr H, Long H, Freedman MF, Drapkin R, Abraham BJ, Young RA, Lawrenson K. Predicting master transcription factors from pan-cancer expression. Nature Genetics, 2020. doi: https://doi.org/10.1101/839142

4.Chaves-Moreira D, Matsubara FH, Schemczssen-Graeff Z, De Bona E, Heidemann VR, Guerra-Duarte C, Gremski LH, Chávez-Olórtegui C, Senff-Ribeiro A, Chaim OM, Arni RK, Veiga SS. Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics. Toxins (Basel). 2019 Jun 19;11(6). pii: E355. doi: 10.3390/toxins11060355. Review. PubMed PMID: 31248109; PubMed Central PMCID: PMC6628458

5.Chaves-Moreira D, Senff-Ribeiro A, Wille ACM, Gremski LH, Chaim OM, Veiga SS. Highlights in the knowledge of brown spider toxins. J Venom Anim Toxins Incl Trop Dis. 2017 Feb 8;23:6. doi: 10.1186/s40409-017-0097-8. eCollection 2017. Review. PubMed PMID: 28194160; PubMed Central PMCID: PMC5299669

6. Mariutti RB, Chaves-Moreira D, Vuitika L, Caruso ÍP, Coronado MA, Azevedo VA, Murakami MT, Veiga SS, Arni RK. Bacterial and Arachnid Sphingomyelinases D: Comparison of Biophysical and Pathological Activities. Journal of cellular biochemistry. 2017; 118(8):2053-2063.

7.Chaves-Moreira D, de Moraes FR, Caruso ÍP, Chaim OM, Senff-Ribeiro A, Ullah A, da Silva LS, Chahine J, Arni RK, Veiga SS. Potential Implications for Designing Drugs Against the Brown Spider Venom Phospholipase-D. Journal of cellular biochemistry. 2017; 118(4):726-738.

8.Chaves-Moreira D, Senff-Ribeiro A, Wille ACM, Gremski LH, Chaim OM, Veiga SS. Highlights in the knowledge of brown spider toxins. The journal of venomous animals and toxins including tropical diseases. 2017; 23:6.

9. Vuitika L, Chaves-Moreira D, Caruso I, Lima MA, Matsubara FH, Murakami MT, Takahashi HK, Toledo MS, Coronado MA, Nader HB, Senff-Ribeiro A, Chaim OM, Arni RK, Veiga SS. Active site mapping of Loxosceles phospholipases D: Biochemical and biological features. Biochimica et biophysica acta. 2016; 1861(9 Pt A):970-979.

10. Buch DR, Souza FN, Meissner GO, Morgon AM, Gremski LH, Ferrer VP, Trevisan-Silva D, Matsubara FH, Boia-Ferreira M, Sade YB, Chaves-Moreira D, Gremski W, Veiga SS, Chaim OM, Senff-Ribeiro A. Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity. Toxicon : official journal of the International Society on Toxinology. 2015; 108:154-66.

11.Chaves-Moreira D, Ullah A, de Moraes FR, Caruso ÍP, Senff-Ribeiro A, Chaim OM, Arni RK, Veiga SS. Potential Implications for Designing Drugs against the Brown Spider Venom Phospholipase-D. Congress of the International Union for Biochemistry and Molecular Biology; 2015 August 24; Foz do Iguazu, PR, BRAZIL.

12. Miller M, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel L, Vogelstein B, Gabelli SB. Molecular Regulation of the PI3K-mTOR Network. AACR Special Conference: Targeting the PI3K-mTOR Network in Cancer; 2014 September 14; Philadelphia, PA, USA. https://doi.org/10.1158/1538-8514.PI3K14-PR02: Molecular Cancer Therapeutics; c2015.

13. Coronado MA, Ullah A, da Silva LS, Chaves-Moreira D, Vuitika L, Chaim OM, Veiga SS, Chahine J, Murakami MT, Arni RK. Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D. Current protein & peptide science. 2015; 16(8):768-74.

14. Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel L, Vogelstein B, Gabelli SB. Cancer Chemistry. AACR Annual Meeting; 2014 April 05; San Diego, CA, USA. https://doi.org/10.1158/1538-7445.AM2014-LB-326: Cancer Research; c2014.

15. Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Kα. Oncotarget. 2014; 5(14):5198-208.

16. Gabelli SB, Echeverria I, Alexander M, Duong-Ly KC, Chaves-Moreira D, Brower ET, Vogelstein B, Amzel LM. Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects. Biophysical reviews. 2014; 6(1):89-95.

17. Vuitika L, Gremski LH, Belisário-Ferrari MR, Chaves-Moreira D, Ferrer VP, Senff-Ribeiro A, Chaim OM, Veiga SS. Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: identification and functional characterization. Journal of cellular biochemistry. 2013; 114(11):2479-92.

18. Wille AC, Chaves-Moreira D, Trevisan-Silva D, Magnoni MG, Boia-Ferreira M, Gremski LH, Gremski W, Chaim OM, Senff-Ribeiro A, Veiga SS. Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom. Toxicon: 2013; 67:17-30.

19. Capelli-Peixoto J, Chávez-Olórtegui C, Chaves-Moreira D, Minozzo JC, Gabardo J, Teixeira KN, Thomaz-Soccol V, Alvarenga LM, de Moura J. Evaluation of the protective potential of a Taenia solium cysticercus mimotope on murine cysticercosis. Vaccine. 2011; 29(51):9473-9.

20.Chaves-Moreira D, Souza FN, Fogaça RT, Mangili OC, Gremski W, Senff-Ribeiro A, Chaim OM, Veiga SS. The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase-D toxin. Journal of cellular biochemistry. 2011; 112(9):2529.

21. de Giuseppe PO, Ullah A, Silva DT, Gremski LH, Wille AC, Chaves Moreira D, Ribeiro AS, Chaim OM, Murakami MT, Veiga SS, Arni RK. Structure of a novel class II phospholipase D: catalytic cleft is modified by a disulphide bridge. Biochemical and biophysical research communications. 2011; 409(4):622-7.

22. Chaim OM, Trevisan-Silva D, Chaves-Moreira D, Wille AC, Ferrer VP, Matsubara FH, Mangili OC, da Silveira RB, Gremski LH, Gremski W, Senff-Ribeiro A, Veiga SS. Brown spider (Loxosceles genus) venom toxins: tools for biological purposes. Toxins. 2011; 3(3):309-44.

23. Ullah A, de Giuseppe PO, Murakami MT, Trevisan-Silva D, Wille AC, Chaves-Moreira D, Gremski LH, da Silveira RB, Sennf-Ribeiro A, Chaim OM, Veiga SS, Arni RK. Crystallization and preliminary X-ray diffraction analysis of a class IIphospholipase D from Loxosceles intermedia venom. Acta crystallographica. Section F, Structural biology and crystallization communications. 2011; 67(Pt 2):234-6.

24.Chaves-Moreira D, Chaim OM, Sade YB, Paludo KS, Gremski LH, Donatti L, de Moura J, Mangili OC, Gremski W, da Silveira RB, Senff-Ribeiro A, Veiga SS. Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase-D (dermonecrotic toxin) from brown spider venom. Journal of cellular biochemistry. 2009; 107(4):655-66.

25. Appel MH, da Silveira RB, Chaim OM, Paludo KS, Silva DT, Chaves DM, da Silva PH, Mangili OC, Senff-Ribeiro A, Gremski W, Nader HB, Veiga SS. Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom. Biochimica et biophysica acta. 2008; 1780(2):167-78.

Research Support

OCRFA: 545754 03/01/2018 - 02/28/2020

Isolation and Characterization of the PAX8 Transcriptional Complex

Goal: Biochemically purify PAX8-interacting partners from benign fallopian tube cells ovarian cancer cells

Role: PI

MCTI/CNPQ: 444609 01/01/2014 - 01/01/2016

Development of inhibitors against the dermonecrotic toxin (phospholipase D) from the venom of brown spiders

Goal: Evaluate the potential implications for designing drugs against Brown Recluse spider bite.

Role: PI

Conference Presentations

Talks

1.Chaves-Moreira D, Mitchell M, Garcia B, Roux R, and Drapkin R. Isolation and Characterization of the PAX8 Transcriptional Complex to Identify Novel Therapeutic Vulnerabilities for Ovarian Cancer. Ovarian Cancer Research Center, University of Pennsylvania. December 7, 2018

2.Chaves-Moreira D, Mitchell M, Garcia B, and Drapkin R. Isolation and characterization of the PAX8 transcriptional complex to identify novel therapeutic vulnerabilities for ovarian cancer. 2017 Center for research on reproduction and women's health symposium, University of Pennsylvania. November 28, 2018

3.Chaves-Moreira D, Mitchell M, Garcia B, Roux R, and Drapkin R. Isolation and characterization of the PAX8 transcriptional complex to identify novel therapeutic vulnerabilities for ovarian cancer. 2017 Center for research on reproduction and women's health symposium, University of Pennsylvania. May 31, 2017.

Posters

1. Abramson Family Cancer Research Institute (AFCRI) - Penn Cancer Research (PCR) Inaugural Postdoctoral Symposium. PAX8 orchestrates an angiogenic program through interaction with SOX17. 2019

2. AACR Advances in Ovarian Cancer Research Special Conference. PAX8 orchestrates an angiogenic program through interaction with SOX17. 2019.

3. AACR annual meeting. Isolation of the PAX8 transcriptional complex to identify novel therapeutic vulnerabilities for ovarian cancer. 2019.

4. 23rd Congress of the International Union for Biochemistry and Molecular Biology. Potential Implications for drugs design against Phospholipase-D from Loxosceles intermedia. 2015.

5. 22nd Annual Meeting of the Institute for Biophysical Research. Thermodynamic and crystallographic analysis of bisphosphonic acids as potent inhibitors of Trypanosoma cruzi FPPS. 2013.

6. XL Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology. The Relationship between Metabolism of Membrane Phospholipids and Hemolysis Induced by Brown Spider Venom Phospholipase-D Toxin. 2011.

7. XXXIX Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology. Identification of a Direct Hemolytic Effect Dependent on the Catalytic Activity Induced by Phospholipase-D from Brown Spider Venom. 2010.

8. XV Annual Meeting of the Brazilian Society of Cellular Biology. The relationship between Calcium and the metabolism of plasma membrane phospholipids in the hemolysis induced by brown spider venom phospholipase-D toxin. 2010.

9. Symposium of the PhD students of the Graduate Program in Cellular and Molecular Biology Program. Biochemistry and biological characterization of Phospholipases present in Loxosceles intermedia and Lonomia obliqua venoms. 2010.

10. Symposium of the PhD students of the Graduate Program in Cellular and Molecular Biology Program. Biochemical characterization and Phospholipase-D Biological present in the brown spider venom. 2009.

11. XIV Annual Meeting of the Brazilian Society of Cellular Biology. Brown spider (Loxosceles intermedia) venom and recombinant Phospholipase-D shows direct hemolytic activity. 2008.

12. XXXV Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology. Molecular cloning and functional characterization of Loxosceles intermedia (brown spider) dermonecrotic recombinant toxins: LiRecDT4 and LiRecDT5. 2006.

13. EVINCI. Cytotoxic activity of the evaluation of the brown spider venom (L.intermedia) on established cell lines in culture. 2006.

14. XXXIV Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology. Deleterius Effects of Brown Spider Venom on Subendothelial Cells. 2005.

15. EVINCI. Cytotoxic activity of the evaluation of the brown spider venom (L.intermedia) on established cell lines in culture. 2005.

16. EVINCI. Cytotoxic activity of the evaluation of the brown spider venom (L.intermedia) on established cell lines in culture. 2004.

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Resume Overview

Companies Worked For:

  • University Of Pennsylvania
  • Federal University Of Parana
  • Johns Hopkins University

School Attended

  • Federal University of Parana

Job Titles Held:

  • Post-doctoral Researcher

Degrees

  • PhD in Molecular And Cell Biology
    Masters in Molecular And Cell Biology
    PharmD in Pharmaceutical Sciences

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