Skilled Biological Scientist focused on [Area of study]. Exceptional research skills with demonstrated success in study design and execution. Well-organized and enthusiastic with good communication and problem-solving skills.
Karig DK, Bessling SL, Thielen P, Zhang S, Wolfe J. Preservation of protein expression systems at elevated temperatures for portable therapeutic production.J R Soc Interface. 2017 Apr;14(129).
Jiang Q, Arnold S, Heanue T, Kilambi KP, Doan B, Kapoor A, Ling AY, Sosa MX, Guy M, Jiang Q, Burzynski G, West K, Bessling S, Griseri P, Amiel J, Fernandez RM, Verheij JB, Hofstra RM, Borrego S, Lyonnet S, Ceccherini I, Gray JJ, Pachnis V, McCallion AS, Chakravarti A. Functional loss of semaphoring 3C and/or semaphoring 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.Am J Hum Genet. 2015 Apr 2;96(4):581-96.
Maragh S, Miller RA, Bessling SL, Wang G, Hook PW, McCallion AS. Rbm24a and Rbm24b are required for normal somitogenesis.PLoS One. 2014 Aug 29;9(8):e105460. eCollection 2014.
Kolawole AO, Li M, Xia C, Fischer AE, Giacobbi NS, Rippinger CM, Proescher JB, Wu SK, Bessling SL, Gamez M, Yu C, Zhang R, Mehoke TS, Pipas JM, Wolfe JT, Lin JS, Feldman AB, Smith TJ, Wobus CE. Flexibility in surface-exposed loops in a virus capsid mediates escape from antibody neutralization.J Virol. 2014 Apr;88(8):4543-57. Epub 2014 Feb 5.
Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, Scott AF, Destrée A, Hennekam RC, Arn PH, Curry CJ, Van Laer L, McCallion AS, Loeys BL, Dietz HC. Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nat Genet. 2012 Nov;44(11):1249-54. Epub 2012 Sep 30.
Gorkin DU, Lee D, Reed X, Fletez-Brant C, Bessling SL, Loftus SK, Beer MA, Pavan WJ, McCallion AS. Integration of ChIP-seq and machine learning reveals enhancers and a predictive regulatory sequence vocabulary in melanocytes.Genome Res. 2012 Nov;22(11):2290-301. Epub 2012 Sep 27.
Hodonsky CJ, Kleinbrink EL, Charney KN, Prasad M, Bessling SL, Jones EA, Srinivasan R, Svaren J, McCallion AS, Antonellis A. SOX10 regulates expression of the SH3-domain kinase binding protein 1 (Sh3kbp1) locus in Schwann cells via an alternative promoter. Mol Cell Neurosci. 2012 Feb;49(2):85-96. Epub 2011 Oct 19.
Maragh S, Miller RA, Bessling SL, McGaughey DM, Wessels MW, de Graaf B, Stone EA, Bertoli-Avella AM, Gearhart JD, Fisher S, McCallion AS. Identification of RNA binding motif proteins essential for cardiovascular development.BMC Dev Biol. 2011 Oct 19;11(1):62.
Stine ZE, McGaughey DM, Bessling SL, Li S, McCallion AS. Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer. Human Molecular Genetics. 2011 Oct 1;20(19):3746-56. Epub 2011 Jul 7.
Ovcharenko I. Genome-wide identification of conserved regulatory function in diverged sequences.Genome Research. 2011 Jul;21(7):1139-49. Epub 2011 May 31.
Antonellis A, Dennis MY, Burzynski G, Huynh J, Maduro V, Hodonsky CJ, Khajavi M, Szigeti K, Mukkamala S, Bessling SL, Pavan WJ, McCallion AS, Lupski JR, Green ED; NISC Comparative Sequencing Program. A rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo.PLoS One. 5(12):e14346, 2010 Dec 16.
Kague E, Bessling SL, Lee J, Hu G, Passos-Bueno MR, Fisher S. Functionally conserved cis-regulatory elements of COL18A1 identified through zebrafish transgenesis.Developmental Biology. 15;337(2):496-505, 2010 Jan.
de Pontual L, Zaghloul NA, Thomas S, Davis EE, McGaughey DM, Dollfus H, Baumann C, Bessling SL, Babarit C, Pelet A, Gascue C, Beales P, Munnich A, Lyonnet S, Etchevers H, Attie-Bitach T, Badano JL, McCallion AS, Katsanis N, Amiel J. Epistasis between RET and BBS mutations modulates enteric innervation and causes syndromic Hirschsprung disease. Proceedings of the National Academy of Sciences. 106(33):13921-6, 2009 Aug 18.
Loftus SK, Antonellis A, Matera I, Renaud G, Baxter LL, Reid D, Wolfsberg TG, Chen Y, Wang C; NISC Comparative Sequencing Program, Prasad MK, Bessling SL, McCallion AS, Green ED, Bennett DC, Pavan WJ. 2009. Gpnmb is a melanoblast-expressed, MITF-dependent gene.Pigment Cell and Melanoma Research. 22(1):99-110, 2009 February.
Xie, J., Bessling, S.L., Cooper, T.K., Dietz, H.C., McCallion, A.S., Fisher, S. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics.; 176(2): 1339–1342., 2007 June.
Fisher, S., Grice, E,A,, Vinton, R.M., Bessling, S.L., Urasaki, A., Kawakami, K., McCallion, A.S. Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish.Nature Protocols. 174, 639-649, 2006.
Fisher, S., Grice, E.A., Vinton R.M., Bessling S.L., McCallion A.S. Conservation of RET regulatory function from human to zebrafish without sequence similarity. Science. 312(5771):276-9, 2006 April.
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