Jessica Claire
Montgomery Street, San Francisco, CA 9XXX5 609 Johnson Ave., 49204, Tulsa, OK
Home: (555) 432-1000 - Cell: - - -
Professional Overview

Experienced scientific researcher with a wide-ranging skill set including a strong biochemistry and analytical chemistry background in addition to broad expertise in FDA regulation.

Skill Highlights
  • Protein expression (bacterial, mammalian and insect cells)
  • Protein detection and quantitation (SDS-PAGE, Western blot, ELISA, immunoprecipitation)
  • Tissue culture (adherent and suspension)
  • Protein functional assay design and optimization (binding and kinetic assays)
  • Protein Purification (affinity, ion exchange and size exclusion chromatography)
  • Experience with AKTA Purification systems and Unicorn software
  • X-ray Crystallography
  • Molecular modeling and docking programs (COOT, PyMol
  • Computer systems: UNIX, LINUX, Windows, MacOSX
  • Computer programs: GraphPrism, MacVector, MSoffice (including excel)
08/2009 to Current
Staff Fellow University Of South Carolina SC, State,
  • Review of Chemistry, Manufacturing and Control (CMC) aspects of original BLAs, supplements, Annual Reports and INDs of various Biologics products submitted to the Office of Blood Research and Review
  • Writing of memos covering review of process and viral clearance validation, stability, bioburden, sterility, extractable/leachables and other manufacturing processes impacting product quality, safety, potency and efficacy in a timely manner to meet deadlines.
  • Participation in meetings (Pre-IND, pre-BLA and other) with sponsor and preparing written responses to sponsor questions pertaining to CMC issues.
  • Conducted research involving understanding neutralizing antibodies against Hepatitis C virus
  • Developed a luciferase-based binding assay to understand viral antigen, host-cell receptor, and antibody interactions for vaccine design and as early stage potency assay.
  • Presented seminars relating to research results and regulatory topics to Division of Hematology
Current to
Undergraduate Research Assistant Massachusetts General Hospital Natick, MA,
  • Synthesized peptide analogs containing spectroscopic probes for protein kinase studies.
05/2006 to 06/2009
Postdoctoral Fellow The University Of Oklahoma Norman, OK,
  • Conducted research to elucidate the processes involved in neurodegenerative and protein aggregation diseases.
  • Studies focused on interactions of various proteins involved in the cellular process of ER-associated degradation (ERAD) and ubiquitin-proteasome protein degradation pathways.
  • Secondary duties of this position included mentoring graduate students and providing training and guidance to technicians in the laboratory.
2006 to 05/2006
Postdoctoral Research Associate University Of San Francisco Sacramento, CA,
  • Conducted structural and function studies of membrane proteins.
  • Research involved preparative scale protein expression using baculovirus system and preparative scale purification using various methods such as affinity, ion-exchange and size exclusion.
  • Studies also included performing crystallization trials using microbatch and vapor diffusion methods.
1999 to 2005
Graduate Research Assistant University Of San Francisco San Francisco, CA,
  • Thesis/ Dissertation: Studies focused on combining crystallographic techniques and kinetic analysis of substrate and inhibitor complexes with native and mutant Cyclooxygenases in order to understand substrate utilization and drug/protein interactions.
  • Studies resulted in two first author publications in the Journal of Biological Chemistry.
  • Research included DNA cloning, site-directed mutagenesis, protein expression in various cells lines including bacteria, insect and mammalian cells, protein purification, thin layer chromatography, protein crystallization and structure determination.
1998 to 1999
Graduate Research Assistant Alpha Teknova Inc. Hollister, CA,
  • Studies focused on transcription, purification and crystallization of large catalytic RNAs to understand the mechanism of catalytic RNAs.
1XXX to 1998
Analytical Chemist Alpha Teknova Inc. Hollister, CA,
  • Method development and validation of analytical HPLC methods for various drug formulations containing multiple drug components.
  • Responsible for following GLP and GMP protocols.
  • Performed raw materials testing according to USP protocols.
1996 to 1XXX
Analytical Chemist University Of North Carolina Greensboro Fort Collins, CO,
  • Performed USP dissolution assays in combination with quantification of time-released drugs formulations using HPLC methods.
  • Performed validation of HPLC methods in compliance with GLP and GMP.
1995 to 1996
Research Assistant Southwestern Council For Higher Education City, STATE,
  • Synthesis, purification, and characterization of monomeric and polymeric materials at Wright Laboratories/Materials Directorate at Wright Patterson Air Force Base.
Expected in 2005
Ph.D: Biochemistry and Molecular Biology
Michigan State University - East Lansing, MI
  • Advisors: William L. Smith and R. Michael Garavito
Expected in 1996
B.S: Biology & Chemistry
Wright State University - Dayton, OH
  • Double Bachelors degree in Biology and Chemistry


Claire, C. A., Rieke, C. J., Garavito, R. M., and Smith, W. L. Crystal structure of arachidonic acid bound to a mutant of Prostaglandin Endoperoxide Synthase-1 that forms predominantly 11-HPETE. J. Biol. Chem. (2004), 279: 42429-35.

Claire, C. A, Kozak, K. R, Marnett, L. J., Smith, W. L., and Garavito, R. M. Structural basis of enantioselective inhibition of COX-1 by (S)--substituted indomethacin ethanolamides. J. Biol. Chem. (2007), 282: 28096-28105.

Lim, P.J., Danner, R., Liang, J., Doong H., Claire, C., Srinivasan D., Rothenberg, C., Wang, H., Ye, Y., Fang, S., and Monteiro, M.J. Ubiquilin and p97/VCP bind Erasin, forming a complex involved in ERAD. J. Cell Biol. (2009), 187(2): 201-17.

Duan, H., Kachko, A., Zhong, L., Struble, Evi., Pandey S., Yan, H., Claire, C., Virata-Theimer, M.L., Deng, L., Zhao, Z., Major, M., Feinstone, S., & Zhang, P. Amino Acid Residue-Specific Neutralization and Non-Neutralization of Hepatitis C Virus by Monoclonal Antibodies to the E2 Protein (2012) J. Virology 86(23): 12686-94

Deng, L., Zhong, L., Struble, E., Ma, L., Claire, C., Yan, H., Virata-Theimer, M.L., Zhao, Z., Feinstone, S., Alter, H., & Zhang, P. Structural Evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus (2013) Proc Natl Acad Sci USA 110(18): 7418-22.

Claire, C., Zhong, L., Deng, L., Duan, Hongying, D., Zhong, Z., Ma, L., Liu, Peter., Struble, E., Yan, H., Feinstone, S., and Zhang, P. A View of the CD81-E2 Interface at the Binding Site of a Neutralizing Antibody against Hepatitis C Virus (in preparation 2013)

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School Attended

  • Michigan State University
  • Wright State University

Job Titles Held:

  • Staff Fellow
  • Undergraduate Research Assistant
  • Postdoctoral Fellow
  • Postdoctoral Research Associate
  • Graduate Research Assistant
  • Graduate Research Assistant
  • Analytical Chemist
  • Analytical Chemist
  • Research Assistant


  • Ph.D
  • B.S

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