senior research associate resume example with 19+ years of experience

Jessica Claire
  • Montgomery Street, San Francisco, CA 94105 609 Johnson Ave., 49204, Tulsa, OK
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Professional Profile

Senior Research Associate with 20 years' experience in protein biochemistry. Areas of expertise include LC-MS characterization of intact and reduced antibodies, LC/MS/MS of peptide maps, assay development for peptide maps, reversed phase, hydrophobic interaction and size-exclusion chromatographies, development and optimization of imaged cIEF, development of carbohydrate assays, assay troubleshooting, assay validation and assay transfer. Author characterization sections of agency filings.

Core Qualifications
  • LC-MS/MS
  • imaged cIEF
  • oligosacharide quantitation by RPHPLC, colorimetric and ELD-PAD HPLC
  • carbohydrate characterization by MALDI-TOF
  • Ellman's Assay
  • Xcallibur, MASCOT, Analyst, Mass Hunter
  • Chemstation, Empower, Chromeleon
  • Microsoft Office
  • Kalaidagraph
  • JMP, statistical analysis
  • Adobe Photoshop
  • SoftMax Pro
Senior Research Associate, 09/2006 - 05/2013
Alector, Inc. Newark, CA,
  • Characterization Scientist for MetMAb, a one armed antibody.
  • Performed sequence variant analysis using MASCOT processing of peptide map LC/MS/MS from three peptide maps.
  • Developed tryptic peptide map for quantitation of degraded peptides by UV and LC/MS/MS.
  • Authored method development reports for titer assay and peptide map.
  • Led phase III validation of assays for quality system. Authored validation protocols and reviewed validation binders for SEC, IEC, CE-SDS, peptide map for identity, and Triton X100 quantitation.
  • Authored characterization sections for IND amendments, end of Phase II pre-meeting package and CTD for Phase III.
  • Presented data and project plans at department, review committee and senior staff meetings.
  • Acted as single point of contact and coordinator for lab move for 40 scientists. Aided in optimization of lab and office space.
  • Assay SubTeam Leader for an antibody drug conjugate project.
Research Associate, 09/1999 - 09/2006
Engine Group Chicago, IL,
  • Characterization scientist for multiple early stage biological molecules including antibody drug conjugates
  • Developed ion-exchange, hydrophobic interaction, size exclusion and reversed phase chromatography methods
  • Optimized LysC and tryptic peptide maps
  • Identified cysteinylation and its effect on ion exchange chromatography and imaged capillary isoelectric focusing
  • Represented department on cross functional teams
  • Presented data at department meetings as well as cross functional teams.
  • Authored characterization sections of IND
  • Authored assay development reports for ion exchange, size exclusion and peptide map assays
  • Participated in validation of assays for control system
  • Analyzed proteins for carbohydrate content and oligosacharide characterization using MALDI-TOF MS, RP-HPLC, colorimetric as well as ECD-PAD detection
  • Authored technical report on quantitation of monosaccharides derivatized with 2-aminobenzoic acid
  • Authored technical report on utilization of SYPRO ruby dye for band quantitation in SDS-PAGE
  • Proposed and guided modification of Ellman's Assay to 96 well plate format. Supervised intern in optimization of the assay to decrease assay time by 75% and protein requirement 80%
Research Associate, 1994 - 08/1999
Exact Sciences Houston, TX,
  • Studied glycerol metabolism in E. coli
  • Studied membrane transport of key intermediates.
  • Developed application of on-line FT-IR for fermentation monitoring
  • Purified enzymes at gram quantities for biochemical and application characterization
  • Member of Emergency Response Team, HAZMAT 24 hr Emergency Response Operations Certification
Master of Arts: Chemistry, Expected in 1993
University of California at Santa Barbara - Santa Barbara, CA
Status -

Isolation and reconstition of the vesamicol receptor/ acetylcholine transporter from synaptic vessicles of Torpedo Californica.

Bachelor of Science: Biochemistry, minor Biotechnology, Expected in 1989
Cal Poly, San Luis Obispo - San Luis Obispo, CA
Status -

Senior Project: set up DNA sequencing lab


Seven Genenchecks for outstanding effort above expected work

2000, distinguished contributer for process sciences

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Resume Overview

School Attended

  • University of California at Santa Barbara
  • Cal Poly, San Luis Obispo

Job Titles Held:

  • Senior Research Associate
  • Research Associate
  • Research Associate


  • Master of Arts
  • Bachelor of Science

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