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Scientist Synthetic Technology Group Resume Example

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SCIENTIST SYNTHETIC TECHNOLOGY GROUP
Summary
Seeking a position as a product development scientist which utilizes my knowledge and experience in synthetic organic chemistry, problem-solving, and emerging technologies in a team-oriented environment.
Highlights
  • Flow - Accendo Conjure, Vapourtec R4 and E2 series, Uniqsis FlowSyn, FlowCat, Syrris Syringe Pumps, Knauer Pumps, and homemade reactors.
  • Hydrogenations (chiral/achiral) - Parr Reactors, Biotage Endeavor, and H.E.L. Cat96.
  • Characterization - NMR, LC-MS, GC-MS (chiral and achiral), SFC, UPLC, DSC, TGA, SEC, UV-Vis. FT-IR, ReactIR, etc.
  • Purification - column chromatography, prep-HPLC, recrystallization, liquid-liquid extraction, membrane chromatography, etc.
  • Parallel Synthesis - Tecan Liquid Handlers, Mettler Toledo Bohdan, and various resins.
  • Computer - Microsoft Office (Outlook, OneNote, Excel, PowerPoint), Adobe Acrobat, SciFinder,
  • Reaxys, ChemDraw, ISIS/Draw, ACDLabs, etc.
  • Communication - Excellent oral and written skills
Experience
Scientist Synthetic Technology Group
September 2011 to July 2015Company Name － City, State
  • Consistently solved synthetic chemistry problems such as improving low yielding transformations, route optimization and accessing new chemical space through consultations or laboratory research Expertise in flow chemistry involving high temperatures, high pressures and thermally unstable materials Experienced at adapting conventional routes to flow chemistry where viable Trained scientist in the use of flow equipment Skilled in biocatalysis for asymmetric synthesis and adept at the development of chiral identification techniques Expertise in optimization of gaseous reactions, such as hydrogenations and carbonylations, both chiral and achiral Trained scientist in the use of the Biotage Endeavor, H.E.L.
  • Cat96, and Parr reactors for the proper use in gaseous reactions, both chiral and achiral.
  • Wrote the SOP for the Biotage Endeavor Highly experienced in synthesizing, characterizing, and handling unstable, highly acutely toxic and carcinogenic compounds Performed DSC analysis of intermediates to determine thermal stability Incorporated design of experiment (DoE) studies into experimental strategies Operated in multi-disciplinary teams involving medicinal, synthetic, process, analytical and computational chemists Presented internally at Groton Chemistry Forum in 2013 and poster sessions.
Scientist Antibacterials
January 2007 to January 2011Company Name － City, State
  • Designed, synthesized, and characterized LpxC inhibitors to treat challenging Gram-negative species, such as P.
  • aeruginosa and K.
  • pneumonia, resulting in the co-invention of a novel series of potent antibacterial LpxC inhibitors Prepared bulk quantities of intermediates and drug candidates for toxicological testing via collaboration with process, pharmaceutical and separation sciences Directed external FTE's to ensure timely delivery of desired analogs and intermediates Operated in multi-disciplinary teams involving medicinal, synthetic, process, analytical and computational chemists, biologists, and drug metabolism scientists Wrote U.S.
  • Patent 8,779,148.
Senior Associate Scientist Antibacterials
January 2004 to August 2007Company Name － City, State
  • Designed, synthesized, and characterized prodrugs of Sulopenem to act as an extended spectrum antibacterial agents with high bioavailability and desired physiochemical properties, leading to the development of three clinical candidates.
  • Recrystallized analogs.
  • Scaled-up (>100 g) and purified desired analogs for toxicology studies and formulation development.
  • Assisted in the development of an internal prodrug database.
Assistant Scientist II
January 2001 to January 2004Company Name － City, State
  • Designed, synthesized, and characterized prodrugs of a beta-lactam to be used as a beta-lactamase inhibitor in order to increase the therapeutic effectiveness of a beta- lactam antibiotic, amoxicillin.
  • Member of the Electronic Notebook Committee which created and beta tested the first internal electronic notebook in discovery.
  • Trained colleagues on the correct usage of the electronic notebook.
Education
M.S : Chemistry, 2001Louisiana State University － City, StateGPA: GPA: 4.00/4.00Chemistry GPA: 4.00/4.00 Adviser: Professor William H. Daly Title: "Synthesis and Characterization of Side Chain Dendritic Polymers" *Developed synthesis of side chain dendritic polymers containing a carboxymethyl cellulose backbone with potential use in drug delivery and catalysis *Experienced in the development of a multi-step organic synthesis of novel macromolecular compounds with extensive use of separations (flash chromatography, HPLC, size exclusion chromatography), spectroscopy (NMR, MS, IR, UV), and other characterization techniques (differential scanning calorimetry, thermogravimetric analysis, viscometry, etc.
B.S : Chemistry, 1997University of West Florida － City, StateGPA: Magna Cum Laude GPA: 3.82/4.00Chemistry Magna Cum Laude GPA: 3.82/4.00
Affiliations
American Chemical Society Member 1996-present *Phi Lambda Upsilon 1997-2001
Personal Information
Patents Preparation of fluoro-pyridinone methylsulfonyl hydroxamate derivatives as antibacterial agents," Brown, Mathew Frank; Che, Ye; Melnick, Michael Joseph; Montgomery, Justin Ian; Plummer, Mark Stephen; Price, Loren Michael; Reilly, Usa; U.S. Patent 8,779,148, July 15, 2014. Publications/Presentations Utilizing CYP2D6 and BACE1 Structure Complexes to Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors," Brodney, Michael A.; Price, Loren M.; et. al. J. Med. Chem. 2015, 58(7), 3223. Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents," McAllister, Laura A.; Price, Loren M.; et al. Biorg. Med. Chem. Lett. 2012, 22, 6832. Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections," Montgomery, Justin I.; Price, Loren M.; et al. J. Med. Chem. 2012, 55(4), 1662. Inactivation of a class A and a class C b-lactamase by 6b-(hydroxymethyl)penicillanic acid sulfone," Papp-Wallace, Krisztina M.; Price, Loren M.; et al. Biochem. Pharm. 2012, 83
Additional Information
  • Patents Preparation of fluoro-pyridinone methylsulfonyl hydroxamate derivatives as antibacterial agents," Brown, Mathew Frank; Che, Ye; Melnick, Michael Joseph; Montgomery, Justin Ian; Plummer, Mark Stephen; Price, Loren Michael; Reilly, Usa; U.S. Patent 8,779,148, July 15, 2014. Publications/Presentations Utilizing CYP2D6 and BACE1 Structure Complexes to Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors," Brodney, Michael A.; Price, Loren M.; et. al. J. Med. Chem. 2015, 58(7), 3223. Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents," McAllister, Laura A.; Price, Loren M.; et al. Biorg. Med. Chem. Lett. 2012, 22, 6832. Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections," Montgomery, Justin I.; Price, Loren M.; et al. J. Med. Chem. 2012, 55(4), 1662. Inactivation of a class A and a class C b-lactamase by 6b-(hydroxymethyl)penicillanic acid sulfone," Papp-Wallace, Krisztina M.; Price, Loren M.; et al. Biochem. Pharm. 2012, 83 4), 462. Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections," Brown, Matthew F.; Price, Loren M.; et al. J. Med. Chem. 2012, 55(2), 914. One-pot (1-ethoxycarbonylcycloprohpyl)triphenylphosphonium tetrafluoroborate ring-opening and Wittig reaction," Chung, Seung Won; Price, Loren M.; et al. Org. Lett. 2011, 13(19), 5338. Synthesis and characterization of a trifunctional aminoamide cellulose derivative," Zhang, Changde; Price, Loren M.; Daly, William H. Biomacromolecules 2012, 7(1), 139. Synthesis of side chain dendritic polymers through divergent techniques on a carboxymethyl cellulose backbone." Price, L. M.; Daly W. H. 4th National Graduate Research Polymer Conference, USM, Hattiesburg, MS, June 18-21, 2000.
  • Awards /Accolades Pfizer Team Award 2006-2007 Multiple Individual Performance Awards 2001-2015 Monsanto Award in Chemistry at UWF 1997 Outstanding Chemistry Award in Organic Chemistry at UWF 1996
Skills

Adobe Acrobat, approach, Chemistry, chemist, Excellent oral, Draw, database, delivery, design of experiment, DSC, flash, FT-IR, GC, HPLC, ISIS, materials, Excel, Microsoft Office, Outlook, PowerPoint, NMR, novel, optimization, problem solving, research, scanning, SOP, UV, written skills

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Resume Overview

School Attended

  • Louisiana State University
  • University of West Florida

Job Titles Held:

  • Scientist Synthetic Technology Group
  • Scientist Antibacterials
  • Senior Associate Scientist Antibacterials
  • Assistant Scientist II

Degrees

  • M.S : Chemistry , 2001
    B.S : Chemistry , 1997

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