Research Specialist Resume Example

As a Gerontologist, Mitochondrial Biologist, and Neuroscientist, my profound experiences (15+ years) and rich knowledge in mitochondrial and neurodegeneration disease research allow me to dissect the mechanism of diseases and developing specific and effective genetic and pharmacological strategies to treat diseases. I am highly organized, proactive and punctual with team-oriented mentality.

Publication Original Articles

1. Tsai P.-I & O'Farrell P.H. (2021) Mitigation of the age-dependent decline in mitochondrial genome integrity. (Submitted toPNAS) - Identified the FIRST potential drug to treat Mitochondrial Disease

2. Lin C.-H.,Tsai P.-I, Lin Y.-I.,Hattori N.,Funayama M., Jeon B., Sato K., Abe K., Mukai Y., Takahashi Y., Li Y., Nishioka K., Yashino H., Daida K., Chen M.-L., Cheng J., Huang C.-Y., Tzeng S.-R., Wu Y.-S., Lai H.-J., Tsai H.-H., Yen R.-F., Lee N.-C., Lo W.-C., Hung Y.-C., Chan C.-C., Farrer M., Wu R.-M., (2020) Mitochondrial respiratory chain complex III (UQCRC1) mutations cause autosomal dominant parkinsonism. Brain,143(11): 3352-3373

3. Tsai P.-I, Lin C.-H., Hsieh C.-H, Papakyrikos A.M., Kim M.J., Napolioni V., Schoor C., Couthouis J., Wu R.-M., Wszolek Z.K., Winter D., Greicius M.D., Ross O.A., Wang X. (2018) PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Mol. Cell, 69: 1-13 - Analyzed in iPSc-derieved neurons, human culture cells, and Drosophila.

4. Tsai P.-I, Papakyrikos A.M., Hsieh C.-H, Wang X. (2017) Drosophila MIC60/Mitofilin Conducts Dual Roles in Mitochondrial Motility and Crista Structure. Mol. Bio. of Cell, 28(24): 3471-79

5. Wang M.-Y., Chen P.-Y., Wang C.-H., Lai T.-T., Tsai P.-I, Cheng Y.-J., Kao H.-H., Chien C.-T. (2016) Dbo/HenjiModulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response. PLOS Genet, 12(10): e1006362

6. Tsai P.-I.,Course M. M., Lovas R. J., Hsieh C.-H., Babic M., Zinsmaier K., Wang X. (2014) PINK1-mediated Phosphorylation of Miro Inhibits Synaptic Growth and Protects Dopaminergic Neurons inDrosophila.Scientific Reports, 4: 6962

7. Tsai P.-I., Wang M.-Y., Kao H.-H., Lin Y.-J., Cheng Y.-J., Chen R.-H., Chien C.-T. (2012) Activity-dependent retrograde Laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions. PNAS, 190(43): 17699-704

8. Tsai P.-I., Wang M.-Y., Kao H.-H., Walker A. J., Chen R.-H., Chien C.-T. (2012) Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions. J. Neuroscience, 32(47): 16971-81

9. Wu P.-R., Tsai P.-I., Chen G.-C., Chou H.-J., Huang Y.-P., Chen Y.-H., Lin M.-Y., Kimchi A., Chien C.-T., and Chen R.-H. (2010) Death-associated protein kinase activates MARK1/2 to regulate microtubule dynamics, neuronal differentiation, and tau toxicity. Cell Death and differentiation, 18(9): 1507-20

10. Lin C.-H.,Tsai P.-I.,Wu R.-M., and Chien C.-T. (2010) LRRK2 G2019SMutation induces dendrite degeneration through mislocalization and phosphorylation of Tau by recruiting autoactivated GSK3β. J. Neuroscience, 30(39): 13138-49

11. Tsai P.-I., Kao H.-I, Grabbe C., Lee Y.-T., Ghose A., Lai T.-T., Peng K.-P., Van Vactor D., Palmer R. H., Chen R.-H., Yeh S.-R., Chien C.-T. (2008) Fak56 functions downstream of integrin aPS3βnand suppresses MAPK activation in neuromuscular junction growth. Neural Development, 3:26

Publication Review Articles

12. Lin C.-H.,Tsai P.-I.,Wu R.-M., and Chien C.-T. (2011) LRRK2 Parkinson's disease: from animal models to cellular mechanisms. Rev. Neurosci., 22(4): 411-8

13. Ho, M. S., Tsai P.-I., and Chien, C.-T. (2006) F-box proteins: the key to protein degradation. J. Biomedical Sci., 13: 181–91

Publication Book

14. Course M. M., Hsieh C.-H., Tsai P.-I., Codding-Bui J. A., and Wang X. (2017) Live Imaging Mitochondrial Transport in Neurons. Function in Neurons, 49-66

• 2014 ~ 2015: PRAP Fellowship of National Science Council of Taiwan (45,000 USD / year; 90,000 USDin total)
• 2013: Dean's Postdoctoral Fellowship, School of Medicine, Stanford University (20,000 USDin total)

Honors:

2017: Janelia Research Campus Conference Travel Grant Awardee

2015: EMBO Conference on Neural Development Travel Grant Awardee

2012: Outstanding PhD Thesis Award, National Taiwan University

2011: 2ndprize poster winner in 1stAsia-Pacific DrosophilaResearch Conference (APDRC)

2011: NPAS (Neuroscience Program in Academia Sinica) Travel Fellowship Awardee

2008: 1stprize poster winner in GRC Conference on Molecular Cellular Neurobiology

2008: Taiwan Society of Cell and Molecular Biology Travel Fellowship Awardee

Activities:

2020: Annual DrosophilaResearch Conference, Washington DC, USA (selected as Oralpresentation, but the conference was cancelled due to COVID-19 crisis)

2019: Annual DrosophilaResearch Conference, Dallas, USA (Oral)

2019: Bay Area Aging Meeting, Novato, USA (Oral)

2017: Janelia Research Campus Conference (Cell Biology of Neurons and Circuits), Virginia, USA (Oral)

2016: 2016 American Society of Cell Biology Annual Meeting, San Francisco, USA (Oral)

2016: Bay Area Traffic Symposium 2016, Berkeley, USA (Oral)

2015: Cell Symposia – Multifaceted Mitochondria, Chicago, USA (Oral)

2011: 1stAsia-Pacific DrosophilaResearch Conference (APDRC), Taipei, Taiwan (Poster)

2010: Axon guidance, synaptogenesis & Neural plasticity, CSHL, USA (Poster)

2008: GRC Conference on Molecular Cellular Neurobiology, Hong Kong (Poster)

2007: Japan DrosophilaResearch Conference, Japan (Oral)

2006: Axon guidance, synaptogenesis & Neural plasticity, CSHL, USA (Poster)