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Skilled Researcher enthusiastic about supporting advancements in biology and drug discovery. Passionate about increasing knowledge to drive growth and needed improvements. Ready to apply knowledge and over ten years of experience in research.
- In vivo experiments techniques
- Drug discovery
- High-throughput screening
- Lentivirus and Adenovirus production and purification
- Human patient liver sample processing
- Isolation of primary hepatocytes
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- The precision-cut liver slice for ex vivo studies
- Metabolomics study
- Cell biology and molecular biology (molecular cloning, CRISPR knock out, and et al)
- RNA-seq
- Histology analysis
- Bacteria culture (Helicobacter pylori)
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Research Scientist, 01/2022 to Current
Lifespan Corporation – Charlestown, RI,
- High throughput screening for the discovery of small molecule NRF2 inhibitors
- Investigate the role of NRF2 in cancer and metabolism
Postdoctoral Research Fellow, 02/2016 to 12/2021
Pacific Medical Centers – Snoqualmie, WA,
- Develop, plan, design, and conduct experiments in the area of long non-coding RNAs regulated by Farnesoid X Receptor (FXR)
- Identify the long non-coding RNAs regulated by FXR using RNA-seq and Global run-on sequencing
- Establish the function of the newly discovered FXR-regulated long non-coding RNA in maintaining bile acid/glucose levels and examine how its functions are dysregulated in diabetes using biochemistry and cellular approach and murine models
- Understand the function of tissue specific FXR in cholestasis using conditional knock-out mice
- Assist in supervision of research activities and methodological teaching of graduate and undergraduate students
- Assist in the preparation of grants and manuscripts
- Collaborate actively with other scientists in the field
- Maintain colonies of laboratory mice
Visiting PHD Student, 01/2013 to 01/2016
University Of Illinois At Urbana-Champaign – City, STATE,
- Develop, plan, design, and conduct experiments in the areas of inflammation and infection
- Establish the function of Brd4 in regulating Helicobacter pylori–Induced Inflammation using biochemistry and cellular approach and murine models
- Establish the role of Brd4 in the regulation of cell senescence in tumor cells
- Assist in the supervision of research activities and methodological teaching of undergraduate students
- Assist in the preparation of grants and manuscripts
- Maintain colonies of laboratory mice
Ph.D.: Biochemical Pharmacology, Expected in 01/2015
Peking Union Medical College, Tsinghua University - Beijing, China,
GPA:
Bachelor of Science: Pharmacy, Expected in 07/2009
Zhejiang University - Hangzhou, China,
GPA:
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