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Professional Summary
Committed researcher with 15 years of experience using cutting edge technology such as CRISPR/Cas9, Super Resolution Microscopy and Affinity Purification Mass Spectrometry to generate and share important information with academic community. Conducted complicated research with integrity and great attention to detail. Adaptable and hardworking individual with excellent problem-solving skills.
Skills
Animal Care and Use: HandClaireg, dissection, and genotyping of the mouse
Molecular biology: Recombinant DNA techniques, western blotting, qRT-PCR, viral transduction, liposome-mediated transfection, immunofluorescence, and Co-IP
Microscopy: Light microscopy, fluorescent/laser confocal microscopy, and super resolution microscopy
Virology: Amplification and purification of lentivirus for in-vitro work
Computer skills: Microsoft word, Excel, PowerPoint, Adobe Photoshop, Adobe Illustrator, ImageJ, FlowJo, and Prism
Work History
10/2015 to CurrentResearch FellowUniversity Of Massachusetts Amherst | Amherst, MA,
Developed the first CRISPR/Cas9 Knock-In mouse model for autosomal dominant polycystic kidney disease (ADPKD) research to investigate the functions of the endogenous Polycystin 1(PC1)-eGFP-3HA fusion protein
Identified novel functional binding partners of PC1 by AP-MS
Established first tissue-specific PC1 protein interactome by AP-MS
10/2013 to 10/2015Visiting FellowEmory University | Atlanta, GA,
Discovered novel roles of PC1 in metabolism and its implications to ADPKD by transcriptomics, metabolomics, and lipidomics
Characterized a mechanistic explanation for both the cellular effects and in vivo phenotypic abnormalities in mice and human that causes autosomal recessive polycystic kidney disease (ARPKD)
Identified novel mitochondrial localization of PC1 and its function in mitochondria
10/2006 to 04/2013PhD. Researcher Loma Linda University Medical Center | Murrieta, CA,
Developed a novel semi-quantitative immunoblotting assay to monitor the micro-autophagic flux
Revealed a general mechanism for cargo specificity and membrane curvature induction of selective microautophagy
Identified a novel mechanism for retaining proteins at a unique membrane contact site
Discovered first evidence that nucleoporin (Nup) regulates nuclear import preferentially in response to heat shock and starvation stress by In vivo nuclear import assay
08/2004 to 09/2006Research AssistantUniversity Of Rochester | City, STATE,
Established primary peritoneal macrophages cultured cells and knockdown TR4 expression using SiRNA by lentiviral transfection
Developed an in vitro foam cell formation assay by Oil Red O staining
Discovered that TR4 is essential for foam cell formation
Education
Expected in 2013Ph.D. | BiologyUniversity of Rochester, Rochester, NY, GPA:
Expected in 2008Master of Science | BiologyUniversity of Rochester, Rochester, NYGPA:
Expected in 1996Bachelor of Science | BiologyNational Sun Yat-Sen University, Kaohsiung, Taiwan, GPA:
Accomplishments
Publications
Claire CC , Kurashige M, Liu Y, Terabayashi T, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick TJ, Prinz W, Xu H, Menezes LF, Germino GG. “A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.” Scientific Reports, 2018 9;8(1):2743. Top 100 in Cell and Molecular Biology of Scientific Reports
Kaimori JY, Claire CC , Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Onuchic LF, Guay-Woodford LM, Germino GG. “NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.” Scientific Reports, 2017 10;7(1):7733.
Menezes LF, Claire CC , Zhou F, Germino GG. “Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease.” EBioMedicine, 2016. 26; 5:183-92.
Makio T, Stanton LH, Claire CC , Goldfarb DS, Weis K, Wozniak RW. “The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly.” J Cell Biol, 2009. 185(3): p. 459-73.
Presentations
Plenary Presentations
“A novel CRISPR/Cas9 eGFP-knock-in mouse for characterizing endogenous polycystin 1” the 15th Annual Mid-Atlantic Nephrology Young Investigator Research Forum, Baltimore, MD, 2020( Second place for the presentation)
“A cleavage product of Polycystin-1 is a mitochondrial matrix protein that regulates mitochondria morphology and function.” American Society for Cell Biology (ASCB) | European Molecular Biology (EMBO) Meeting, Philadelphia, PA, 2017
“Polycystic Kidney Disease: The underlying genetic architecture may explain the susceptibility of PKD1 to mutations.” The American Society of Human Genetics Annual Meeting, Vancouver Canada, 2016
Poster Presentations
Claire CC , Kurashige M, Terabayashi T, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick TJ, Prinz W, Menezes LF, Germino GG. “Polycystin-1 is a mitochondrial protein that regulates mitochondria morphology and function.” FASEB Science Research Conferences, Polycystic Kidney Disease: Challenges, differing viewpoints and ways forward, Big Sky, Montana, 2017
Claire CC , Goldfarb DS, “Physiological role of the membrane contact site: Nucleus-Vacuole (NV) junctions.“ The American Society for Cell Biology Annual Meeting, Denver, Colorado, 2011
Liu LK, Claire CC , Goldfarb DS, “Proteostatic control of nuclear targeting pathways by the nuclear pore complex protein, Nup42.” The American Society for Cell Biology Annual Meeting, Denver, Colorado, 2011
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