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research associate resume example with 11+ years of experience

Jessica Claire
  • , , 609 Johnson Ave., 49204, Tulsa, OK 100 Montgomery St. 10th Floor
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Professional Summary

PUBLICATIONS:

Claire Y, et al. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022;146:699–714 (cited by 8)

Maturation of human induced pluripotent stem cell-derived cardiomyocytes for modeling hypertrophic cardiomyopathy. WE Knight, Y Cao, YH Lin, GC Sparagna, B Bai, Y Claire, C Chi, Y Du, et al. Stem Cell Reports, Vol. 16, 519–533, March 9, 2021. (cited by 30)

Riching AS, Danis E, Claire Y, Cao Y, Chi C, Bagchi RA, Klein BJ, Xu H, Kutateladze TG, McKinsey TA, Buttrick PM, Song K. (2020) Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. Journal of Molecular and Cellular Cardiology. 2020 Dec 24. (cited by 17)

Chi C, Leonard A, Knight WE, Beussman KM, Claire Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K (2018). LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2018 Dec 24. pii: 201808618. doi: 10.1073/pnas.1808618116. (cited by 69)

Riching AS, Claire Y, Cao Y, Londono P, Xu H, Song K (2018). Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes. J Vis Exp. 2018 June 3; (136). doi: 10.3791/57687 (cited by 6)

Claire Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O’Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, and Song K. (2015) High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signaling. Nature Communications, 6: 8243. (cited by 207)

Claire, Y., Shen, Y., Yang, S., Wang, J., Hu, Q., Wang, Y., and He, Q. (2010). Ubiquitin ligase components Cullin4 and DDB1 are essential for DNA methylation in Neurospora crassa. J Biol Chem 285, 4355-4365. (cited by 58)


GRANTS:

National Natural Science Foundation of China (Grant No.31200930): ORC complex regulates epigenetic modifications in Neurospora crassa


PATENT AND HONORS:

2015 High efficiency reprogramming of fibroblasts into cardiomyocytes (patent number: 9885018/10519423).

2009 Dafu Yu Scholarship, China Agricultural University, Beijing, China 2009 KDN Scholarship, China Agricultural University, Beijing, China

Skills

    CRISPR/Cas9 hiPSCs genome editing

    Neonatal/Adult Mouse CM isolation

    Small animal ECG analysis

    Protein and nucleotide biochemistry

    Virus production and handling

    Ca2+ transient analysis

    High-throughput drug screening

    Cardiomyocytes differentiation

    Stem cell technique

    Tissue histology

    RNA FISH

Work History
Research Associate, 08/2021 to Current
Loma Linda University Medical CenterMurrieta-Main, CA,

Research Project-1:

Explore the molecular function of a circadian controlled lncRNA in ischemic heart disease.

Research Project-2:

Explore the molecular function of a RBP in ischemic/hypertrophic heart disease.

Research Project-3:

Use iCM in genetic testing for cardiovascular diseases.

Postdoctoral Research Fellow, 11/2013 to 06/2021
The University Of OklahomaNorman, OK,

Research Project-1: -High-efficiency direct reprogramming from fibroblasts into cardiomyocytes.

•Mammalian cell line cell culture.

•Mouse primary fibroblasts isolation and culturing.

•Lentiviral/Retroviral/ vector design, production, and purification. •Fibroblasts Direct Cardiac Reprogramming.

•DNA, RNA and Protein extraction, Flow Cytometry, qPCR, Western Blot.


Research Project-2: -Drug screening of small Molecule that promotes cardiomyocytes proliferation.

•Mouse/Rat neonatal cardiomyocytes isolation.

•Mouse primary cardiomyocytes cell culture.

•High-Throughout drug screening with neonatal cardiomyocytes.

•Edu incorporation and Click-iT detection in neonatal cardiomyocytes.


Research Project-3: -Investigating a novel LncRNA’s function in heart. •Human iPSC cell line cell culture.

•Human iPSC cell differentiation to cardiomyocytes.

•CRISPR genome editing in hiPSC.

•Mouse CRISPR genome editing colony management.

•Mouse neonatal/adult cardiomyocytes isolation and culturing.

•Small animal ECG analysis.

•Mouse minipump implantation.

•Lentiviral/Retroviral/Adenoviral/Adeno Associated viral vector design, production and purification.

•Ca2+ transient and contractility analysis of cardiomyocytes.

•Histology analysis of cardiac tissue sections.

•Conventional and single molecule Fluorescent In situ Hybridization in cells.

•In vitro RNA and Protein production.

•LncRNA tagging and immunoprecipitation of DNA/RNA/protein.

Advisor: Kunhua Song, PhD


Postdoctoral Research Fellow, 09/2011 to 07/2013
The University Of OklahomaNorman, OK,

Research Project: -ORC complex regulates epigenetic modifications in Neurospora crassa.

•Generate Origin Recognition Complex (ORC) gene knockout strains. •Make constructs of ORC components.

•IP detection the interaction of ORC with histone modifying enzymes. •ChIP detection of histone modifying enzymes chromatin localization in individual ORC knockoutstrains.

•ChIP detection of histone modifications alteration in individual ORC knockout strains.

Advisor: Qun He, PhD

Education
Ph.D.: Microbiology, Expected in 07/2011 to College of Biological Sciences, China Agricultural - Beijing, China,
GPA:

Research Project: Ubiquitin ligase components Cullin4 and DDB1 regulate H3K9 and DNA methylationin Neurospora crassa

•Generate gene knockout strains.

•DNA methylation detection in cells.

•Chromatin immunoprecipitation (ChIP) detection of H3K9me3 in cells. •Protein immunoprecipitation (IP) detection protein interaction in multi-components E3 ligase.

•DNA, RNA and Protein Extraction, qPCR, Western.

Advisor: Qun He, PhD

Bachelor of Science: Biology, Expected in 07/2005 to College of Life Sciences, WuHan University - Wuhan, China,
GPA:

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Resume Overview

School Attended

  • College of Biological Sciences, China Agricultural
  • College of Life Sciences, WuHan University

Job Titles Held:

  • Research Associate
  • Postdoctoral Research Fellow
  • Postdoctoral Research Fellow

Degrees

  • Ph.D.
  • Bachelor of Science

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