More than 8 years of research experience in design, synthesis, and characterization of different small molecules for biological studies and organometallic compounds for catalysis. Initiated a new project which is currently funding by National Institutes of Health (NIH), and leads to 3 publications and one patent. Ideal team player who has extensive experience in working with people from different research areas. Experience leading lab development, and mentoring professional growth of research trainees.
- Research design
- Air-free techniques
- Organic synthesis
- Solid phase peptide synthesis
- Mass spectrometry
- NMR
- High performance liquid chromatography (HPLC)
- Automated microwave peptide synthesizer
- Gel permeation chromatography (GPC)
- UV/Vis Spectroscopy/IR
- Column chromatography
- Flash chromatography
- Glovebox
- Word, Excel, PowerPoint, Adobe illustrator
- Mestrenova, Topspin, FreeStyle
- LinkedIn: www.linkedin.com/in/kuei-chien-Claire
Cambridge, MA, 08/2020 - Current
1. Develop and synthesize azoline small molecules for one-step azolation strategy for site-and chemo-selective labeling of proteins with mass-sensitive probes.
2. Design and synthesize various types of tunable azole and azolinium ion for lysine profiling and intracellular labeling of proteins in different cell lines.
3. Develop of tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling.
4. Chemical tools for selective tagging mono-methyl lysine.
5. Site-selective lysine modification via K-me directed modification.
Boston, MA, 09/2016 - 07/2017
1. Synthesis and investigation of 4-phenylchromane derivatives as the synergistic agent of cisplatin.
2. Develop the new methodology to couple the chromanone with the aryl halide and arylboronic acids by the direct Pd-catalyzed C-H bond arylation.
Allston, MA, 07/2015 - 09/2016
1. Preparation of Lea, Leb oligosaccharides building blocks for making type I LacNAc (GalĪ²1 ā 3GlcNAc) hexa- and octasaccharides.
2. Total synthesis of well-known galectin inhibitor TD139 and its derivatives.
1. JessicaClaire, Julia Donovan, Yuwen Wang, Monika. Raj āOxidative Triazene Cyclization of Secondary Amines for Tagging Monomethyl Lysine Post-Translational Modificationāā manuscript preparation
2. JessicaClaire, Monika. Raj āChemo-selective and Site-Selective K(me)-Directed Lysine Modification for Kme-directed modification (Kme-DM) ā manuscript preparation
3. JessicaClaire, Keriann M. Backus, Monika Raj āTunable Heteroaromatic Azoline thioethers (HAT) for Cysteine Profilingā Chem. Sci. 2022, 13, 763ā774
4. JessicaClaire, Jian Cao, Lisa M. Boatner, Linwei Li, Jonathan Farhi, Kendall N. Houk, Jennifer Spangle, Keriann M. Backus, Monika Raj āTunable Amine Reactive Electrophile (TARE) for Selective Profiling of Lysine in Proteomeā Angew. Chem. Int. Ed. 2021, 60, 2ā11
5. JessicaClaire, Monika. Raj āOneāStep Azolation Strategy for Siteā and ChemoāSelective Labeling of Proteins with MassāSensitive Probesā Angew. Chem. Int. Ed. 2021, 60, 1797-1805.
6. Mahesh Sriram, Kuei-Chen Claire, Monika Raj āAmide bond activation of biological moleculesā Molecules. 2018, 23, 2615. (Invited Review article)
7. Yu-Feng Lin, Chi Fong, Wan-Ling Peng, Chia-Hsien Lu, JessicaClaire, Wen-Tai Li āSynthesis of 3-(2-Olefinbenzyl)-4H-chromen-4-one through Cyclobenzylation and Catalytic C-H Bond Functionalization with Palladiumā J. Org. Chem. 2017, 82, 20, 10855ā10865.
By clicking Customize This Resume, you agree to ourĀ Terms of UseĀ andĀ Privacy Policy
Disclaimer
Resumes, and other information uploaded or provided by the user, are considered User Content governed by our Terms & Conditions. As such, it is not owned by us, and it is the user who retains ownership over such content.
How this resume score
could be improved?
Many factors go into creating a strong resume. Here are a few tweaks that could improve the score of this resume:
resume Strength
- Length
- Personalization
- Strong Summary
- Target Job
Resume Overview
School Attended
- Emory University
- National Sun Yat-Sen University
- National Dong Hwa University
Job Titles Held:
- Research Assistant
- Research Assistant
- Research Assistant
Degrees
- Ph.D.
- Master of Science
- Bachelor of Science
By clicking Customize This Resume, you agree to ourĀ Terms of UseĀ andĀ Privacy Policy
