More than 8 years of research experience in design, synthesis, and characterization of different small molecules for biological studies and organometallic compounds for catalysis. Initiated a new project which is currently funding by National Institutes of Health (NIH), and leads to 3 publications and one patent. Ideal team player who has extensive experience in working with people from different research areas. Experience leading lab development, and mentoring professional growth of research trainees.
1. Develop and synthesize azoline small molecules for one-step azolation strategy for site-and chemo-selective labeling of proteins with mass-sensitive probes.
2. Design and synthesize various types of tunable azole and azolinium ion for lysine profiling and intracellular labeling of proteins in different cell lines.
3. Develop of tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling.
4. Chemical tools for selective tagging mono-methyl lysine.
5. Site-selective lysine modification via K-me directed modification.
1. Synthesis and investigation of 4-phenylchromane derivatives as the synergistic agent of cisplatin.
2. Develop the new methodology to couple the chromanone with the aryl halide and arylboronic acids by the direct Pd-catalyzed C-H bond arylation.
1. Preparation of Lea, Leb oligosaccharides building blocks for making type I LacNAc (Galβ1 ā 3GlcNAc) hexa- and octasaccharides.
2. Total synthesis of well-known galectin inhibitor TD139 and its derivatives.
1. JessicaClaire, Julia Donovan, Yuwen Wang, Monika. Raj āOxidative Triazene Cyclization of Secondary Amines for Tagging Monomethyl Lysine Post-Translational Modificationāā manuscript preparation
2. JessicaClaire, Monika. Raj āChemo-selective and Site-Selective K(me)-Directed Lysine Modification for Kme-directed modification (Kme-DM) ā manuscript preparation
3. JessicaClaire, Keriann M. Backus, Monika Raj āTunable Heteroaromatic Azoline thioethers (HAT) for Cysteine Profilingā Chem. Sci. 2022, 13, 763ā774
4. JessicaClaire, Jian Cao, Lisa M. Boatner, Linwei Li, Jonathan Farhi, Kendall N. Houk, Jennifer Spangle, Keriann M. Backus, Monika Raj āTunable Amine Reactive Electrophile (TARE) for Selective Profiling of Lysine in Proteomeā Angew. Chem. Int. Ed. 2021, 60, 2ā11
5. JessicaClaire, Monika. Raj āOneāStep Azolation Strategy for Siteā and ChemoāSelective Labeling of Proteins with MassāSensitive Probesā Angew. Chem. Int. Ed. 2021, 60, 1797-1805.
6. Mahesh Sriram, Kuei-Chen Claire, Monika Raj āAmide bond activation of biological moleculesā Molecules. 2018, 23, 2615. (Invited Review article)
7. Yu-Feng Lin, Chi Fong, Wan-Ling Peng, Chia-Hsien Lu, JessicaClaire, Wen-Tai Li āSynthesis of 3-(2-Olefinbenzyl)-4H-chromen-4-one through Cyclobenzylation and Catalytic C-H Bond Functionalization with Palladiumā J. Org. Chem. 2017, 82, 20, 10855ā10865.
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