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Professional Summary

More than 8 years of research experience in design, synthesis, and characterization of different small molecules for biological studies and organometallic compounds for catalysis. Initiated a new project which is currently funding by National Institutes of Health (NIH), and leads to 3 publications and one patent. Ideal team player who has extensive experience in working with people from different research areas. Experience leading lab development, and mentoring professional growth of research trainees.

  • Research design
  • Air-free techniques
  • Organic synthesis
  • Solid phase peptide synthesis
  • Mass spectrometry
  • NMR
  • High performance liquid chromatography (HPLC)
  • Automated microwave peptide synthesizer
  • Gel permeation chromatography (GPC)
  • UV/Vis Spectroscopy/IR
  • Column chromatography
  • Flash chromatography
  • Glovebox
  • Word, Excel, PowerPoint, Adobe illustrator
  • Mestrenova, Topspin, FreeStyle
Emory University Atlanta, GA Expected in 08/2022 Ph.D. : Chemistry - GPA :
National Sun Yat-Sen University Kaohsiung, Taiwan, Expected in 06/2014 Master of Science : Chemistry - GPA :
National Dong Hwa University Hualien, Taiwan, Expected in 06/2012 Bachelor of Science : Chemistry - GPA :
Research Experience
Harvard University - Research Assistant
Cambridge, MA, 08/2020 - Current

1. Develop and synthesize azoline small molecules for one-step azolation strategy for site-and chemo-selective labeling of proteins with mass-sensitive probes.
2. Design and synthesize various types of tunable azole and azolinium ion for lysine profiling and intracellular labeling of proteins in different cell lines.
3. Develop of tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling.
4. Chemical tools for selective tagging mono-methyl lysine.
5. Site-selective lysine modification via K-me directed modification.

Harvard University - Research Assistant
Boston, MA, 09/2016 - 07/2017

1. Synthesis and investigation of 4-phenylchromane derivatives as the synergistic agent of cisplatin.
2. Develop the new methodology to couple the chromanone with the aryl halide and arylboronic acids by the direct Pd-catalyzed C-H bond arylation.

Harvard University - Research Assistant
Allston, MA, 07/2015 - 09/2016

1. Preparation of Lea, Leb oligosaccharides building blocks for making type I LacNAc (Galβ1 → 3GlcNAc) hexa- and octasaccharides.
2. Total synthesis of well-known galectin inhibitor TD139 and its derivatives.


1. JessicaClaire, Julia Donovan, Yuwen Wang, Monika. Raj “Oxidative Triazene Cyclization of Secondary Amines for Tagging Monomethyl Lysine Post-Translational Modification’’ manuscript preparation
2. JessicaClaire, Monika. Raj “Chemo-selective and Site-Selective K(me)-Directed Lysine Modification for Kme-directed modification (Kme-DM) ” manuscript preparation
3. JessicaClaire, Keriann M. Backus, Monika Raj “Tunable Heteroaromatic Azoline thioethers (HAT) for Cysteine Profiling” Chem. Sci. 2022, 13, 763–774
4. JessicaClaire, Jian Cao, Lisa M. Boatner, Linwei Li, Jonathan Farhi, Kendall N. Houk, Jennifer Spangle, Keriann M. Backus, Monika Raj “Tunable Amine Reactive Electrophile (TARE) for Selective Profiling of Lysine in Proteome” Angew. Chem. Int. Ed. 2021, 60, 2–11
5. JessicaClaire, Monika. Raj “One‐Step Azolation Strategy for Site‐ and Chemo‐Selective Labeling of Proteins with Mass‐Sensitive Probes” Angew. Chem. Int. Ed. 2021, 60, 1797-1805.
6. Mahesh Sriram, Kuei-Chen Claire, Monika Raj “Amide bond activation of biological molecules” Molecules. 2018, 23, 2615. (Invited Review article)
7. Yu-Feng Lin, Chi Fong, Wan-Ling Peng, Chia-Hsien Lu, JessicaClaire, Wen-Tai Li “Synthesis of 3-(2-Olefinbenzyl)-4H-chromen-4-one through Cyclobenzylation and Catalytic C-H Bond Functionalization with Palladium” J. Org. Chem. 2017, 82, 20, 10855–10865.

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School Attended

  • Emory University
  • National Sun Yat-Sen University
  • National Dong Hwa University

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  • Research Assistant
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