Preclinical (in vitro and in vivo) research experience in materials characterization using various analytical methods, and in designing and executing laboratory protocols and SOPs. Additional experience in R&D, Product Development, and Technology Transfer in biotechnology industry. Strong interpersonal skills allowing ability to successfully work in interdisciplinary teams as well as working independently.
Dissertation: Characterizing and engineering microtubule properties for use in hybrid nanodevices.
Secondary Science Education; concentration in Biology
concentration in Clinical Laboratory Sciences
1. D. F. Abrahams, Y. Jeune-Smith, A. Bode, M. Baldwin and J. W. Choi. Real-time ultrasound guided needle injection of the mouse jugular vein. Current Protocols in Mouse Biology, 2014, 4, 141
2. N. K. Tafreshi, A. Silva, V.C. Estrella, T.W. McCardle, T. Chen, Y. Jeune-Smith, S.A. Enkemann, K. Smalley, V. K. Sondak, J. Vagner and D.L. Morse. In vivo and in silico pharmacokinetics and biodistribution of a melanocortin receptor 1 targeted agent in preclinical models in melanoma. Molecular Pharmaceutics, 2013, 10(8), 3175
3. S. He, A. T. Lam, Y. Jeune-Smith and H. Hess. Modeling negative cooperativity in streptavidin adsorption onto biotinylated microtubules. Langmuir, 2012, 28, 10635
4. Y Jeune-Smith, A. Agarwal and H. Hess. Cargo loading onto kinesin-powered molecular shuttles. Journal of Visualized Experiments, 2010, 45, e2006
5. Y. Jeune-Smith and H. Hess. Engineering the length distribution of microtubules polymerized in vitro. Soft Matter, 2010, 6, 1778
6. Y. Jeune and H. Hess: “A novel laboratory for undergraduate students: using microtubules to illustrate polymer properties”, Caltech Chemical Bonding Center NSF Site Visit, Pasadena, CA (February 2008) Oral Presentation and peer-reviewed manuscript in Conference Proceedings.
1. Y. Jeune-Smith “Characterizing Cancer Tumor Targeting Agents”, Hillsborough Community College Science Seminar, Tampa, FL (2012, 2013) Invited Speaker
2. Y. Jeune-Smith, A. Cohen, N. Tafreshi, J. Vagner, R. Gillies and D. Morse. “In Vivo Fluorescence Lifetime Imaging Differentiates the Bound versus Unbound State of a Cell-Surface Receptor Targeted Ligand”, AACR 2013, Washington, DC (April 2013) Poster presentation
3. Y. Jeune-Smith, J. Josan, C. Weber, A. Silva, R. Lynch, J. Vagner, V. Hruby, R. Gillies and D. Morse. “Characterization of Multivalent Targeted Molecular Imaging Probes”, World Molecular Imaging Congress 2012 Annual Meeting, Dublin Ireland (September 2012) 1st place Poster Award
4. Y. Jeune, K. Nittala and H. Hess: “Fatigue and wear of microtubules induced by kinesin motor activity”, Materials Research Society Spring Meeting, San Francisco, CA (March 2008)
5. Y. Jeune and H. Hess: “A novel laboratory for undergraduate students: using microtubules to illustrate polymer properties”, Caltech Chemical Bonding Center NSF Site Visit, Pasadena, CA (February 2008) Oral Presentation and peer-reviewed manuscript in Conference Proceedings.
6. Y. Jeune and H. Hess: “Wear in active nanosystems powered by biomolecular motors”, Gordon Research Conference on the Physics and Chemistry of Microfluidics, Waterville Valley, NH (July 2007)
Research: Experimental design; Spectroscopy and microscopy techniques; In vitro motor protein assays; Cell/tissue culture; DNA transfection and clone selection; Flow cytometry; Live animal research and animal handling; Data and statistical analysis
Software: Statistics (GraphPad, Origin, SPSS); Image analysis (Living Image, ImageJ, Optiview, TrueQuant); Productivity (Access Database, Excel, Powerpoint, Publisher, Word), Inteum
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