Postdoctoral Research Fellow Dr Frank Slack Lab Resume Example

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Jessica Claire
Montgomery Street, San Francisco, CA 94105 (555) 432-1000,
  • Research fellow: 8+ years experience, Formal training in translational oncology
  • Experience in therapeutic development and small molecule and biologics drug discovery, cancer cell signaling, metabolism, and immunology, broad technical experience in cell and molecular biology.
  • Highly collaborative, team player with proven track record of conducting and managing multiple intra and inter- institutional collaborative projects, preparing standard reports, technical writing, publishing the findings in high caliber journals, and mentoring.
Expected in 2014 Ph.D. | Biomedical Sciences, Cancer Biology and Cell Biology University of Texas Health Science Center at Houston and UT MD Anderson Cancer Center, Houston, Texas GPA:
  • Thesis: Understanding tumor microenvironment influences on miRNA biogenesis down regulation in cancers
  • Additional projects on understanding long noncoding RNA role in cancer metabolism alterations, and hypoxia biology influence on SUMO interactions.
Expected in 2009 Master of Science | Biotechnology University of Texas at San Antonio, San Antonio, Texas GPA:
  • Thesis: Role of TGFBIp induced apoptosis in Diabetes Mellitus and Osteosarcoma
Expected in 2007 Bachelor of Science | Biotechnology Visvesvaraya Technological University, Belgaum, GPA:
  • Undergraduate research experience on plant biology and in vitro clonal propagations, RAPD based polymorphism studies
Work Experience
06/2015 to Current Postdoctoral Research Fellow, Dr. Frank Slack Lab Arizona State University | Tempe, AZ,
  • Managed project on developing of novel small molecule therapeutics for lung cancer. Developed high throughput assay for small molecule screen. Independently carried out small molecule screen, involved liquid handling, automated robotics, and high content imaging. Carried-out cell-based assays for combination index, Next Gen Sequencing and bioinformatics analysis to understand biology of novel lead compound, and in vivo testing of therapeutic potential of lead compounds.
  • Developing noncoding RNA based therapeutics for EGFR and KRAS mutant lung cancers.  Leading and executing the project on the identification of co-deregulated long noncoding RNAs in EGFR or KRAS mutant lung cancer patient sample based transcriptome data, functional characterization using genomic and cell line based tools such as siRNAs, and currently developing CRISPR techniques. 
2015 to 06/2015 Postdoctoral Research Fellow, Dr. Anil Sood Lab UT MD Anderson Cancer Center | City, STATE,
  • Studied the role of SUMO proteins in hypoxia signaling. Used 2 Dimensional Gel Electrophoresis and Mass Spectrometry (MS-MS) to identify potential SUMO binding partners. Investigated effect of SUMO deregulation for cancer survival under hypoxia and in the tumor microenvironment. 
  • Mentored and trained undergraduate and high school students. 
07/2009 to 11/2014 Graduate Research Assistant, Dr. Anil Sood Lab Graduate School Of Biomedical Sciences, UT MD Anderson Cancer Center, UT Health Science Center | City, STATE,
  • Project focussed on testing of tumor microenvironment factors influence on the cancer growth and progression, used findings to develop and test RNA based therapeutic strategies.
  • Discovered for the first time role of long noncoding RNA called NRCP in regulation of cancer cell metabolism via alteration in glycolysis.
  • Managed several collaborative projects, and conducted in vivo mouse studies (syngeneic and immune compromised) with various test therapeutic compounds (small molecule and antibody based) in ovarian, breast and lung cancer.
  • Used large array of cell based techniques such as transfection, RNA-Seq, development of stable cell lines, and mouse model of ovarian, breast cancers. 
11/2007 to 06/2009 Research Assistant, Dr. Richard LeBaron Lab University Of Texas At San Antonio | City, STATE,
  • Conducted the project on understanding functions of protein TGFBIp in osteosarcoma and Diabetes Mellitus.
  • Identified the protein domain responsible for function of TGFBIp as apoptosis inducer in the above two diseases.  
  • Used protein and RNA based techniques such as PCR, cloning, protein production, column based purification, and Western blots
07/2007 to 11/2007 Tutor Thomas Rivera Center, University Of Texas At San Antonio | City, STATE,
  • Trained the students on undergraduate level mathematics, biochemistry.
  • Conducted tutoring classes on need basis.
Key Publications
  • R Rupaimoole, F J Slack. MicroRNAs as drugs: New era for therapeutic management of cancer and other diseases. Nature Reviews in Drug Discovery (Accepted, In press).   
  • R Rupaimoole, F J Slack. A role for miR- 34 in colon cancer stem cell homeostasis. Stem Cell Investigation 3 42 (2016).
  • S Y Wu, R Rupaimoole, … A K Sood. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nature Communications DOI:10.1038/ncomms11169 (2016)
  • B Zand, R A Previs, N M Zacharias, R Rupaimoole, … A K Sood. Role of Increased n-acetylaspartate Levels in Cancer. Journal of the National Cancer Institute 108 (6)  DOI:10.1093/jnci/djv426 (2016)
  • R Rupaimoole, G A Calin, G Lopez-Berestein, A K Sood. MiRNA Deregulation in Cancer Cells and the Tumor Microenvironment. Cancer discovery 6 (3) 235-246 (2016)
  • R Rupaimoole, C Ivan, D Yang, S Y Wu, … A K Sood. Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. Oncogene  DOI:10.1038/onc.2015.492 (2016)
  • R Rupaimoole, J Lee, M Haemmerle, … A K Sood. Novel noncoding RNA NRCP role in metabolic reprogramming of cancer cells. Cell Reports 13 2395–2402 (2015)
  • G Liu, D Yang, R Rupaimoole, … A K Sood, W Zhang. Augmentation of Response to Chemotherapy by microRNA-506 Through Regulation of RAD51 in Serous Ovarian Cancers. Journal of the National Cancer Institute 107 (7): doi: 10.1093/jnci/djv108 (2015)
  • R Rupaimoole, S Y W, S Pradeep, … A K Sood. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nature Communications DOI: 10.1038/ncomms6202 (2014)
  • C V Pecot, R Rupaimoole, D Yang, … A K Sood. Tumour angiogenesis regulation by the miR-200 family. Nature Communications. 4 (2013)
  • R Zamilpa, R Rupaimoole, C F Phelix, M Somaraki-Cormier, … R G Lebaron. C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. Matrix Biology. 28-6: 347-355 (2009)

For Full list please refer to Google Scholar Profile: 
Technical Skills
  • Molecular Biology: Real Time PCR, Site Directed Mutagenesis, Gene Knockdown through ShRNA/SiRNA, Northern Blotting, Southern Blotting, ChIP  and RIP assay, luciferase system.
  • Protein techniques: Protein Expression and column based purification from bacterial and insect cell system, SDS-PAGE, Immunoprecipitation, Western Blotting, Enzyme Linked Immuno Sorbent Assay (ELISA).
  • Specialized techniques: Handling and maintenance of human transformed cell lines, primary cell lines, establishing stable cell lines, blood and immune cells isolation and flow cytometry analysis, cytokine analysis, robotics and automated systems, Histological studies including cryo Sectioning, immuno/histology staining, confocal and fluorescence microscopy, high content imaging.
  • In vivo: Animal (mouse) handling, orthotropic implantation of cancer cells for development of ovarian, breast, lung, endometrial, prostate, liver, spleen, brain tumors, work experience with genetic mouse models.
  • Programming UNIX and R, NGS data analysis, Rasmol, PDB Viewer, Ingenuity pathway analysis (IPA), Netwalker.
Awards, Organizations
  • Aspen Cancer Conference Fellowship, Aspen 2016
  • President's Research Scholarship, University of Texas Health Science Center and UT MD Anderson Cancer Center, Graduate School of Biomedical Sciences. 2014
  • Hawkins discovery fellowship, Graduate School of Biomedical Sciences, UT MD Anderson Cancer Center (3 Yrs). 2010
  • Member: American Association for Cancer Research, American Association for Advancement of Sciences
Additional training
  • 12 day hands-on training in NGS Data Analysis covering NGS-Analysis and UNIX, R programming. 2016 – TC Chan School of Public Health Bioinformatics core, Harvard Medical School.  
  • Workshop on Oncomine: analysis of data using publicly available data sets. 2014- U.T. MD Anderson Cancer Center.  
  • Workshop on Ingenuity pathway analysis: Practical training on analysis of biological datasets using Ingenuity tools. 2012- U. T. MD Anderson Cancer Center.

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School Attended
  • University of Texas Health Science Center at Houston and UT MD Anderson Cancer Center
  • University of Texas at San Antonio
  • Visvesvaraya Technological University
Job Titles Held:
  • Postdoctoral Research Fellow, Dr. Frank Slack Lab
  • Postdoctoral Research Fellow, Dr. Anil Sood Lab
  • Graduate Research Assistant, Dr. Anil Sood Lab
  • Research Assistant, Dr. Richard LeBaron Lab
  • Tutor
  • Ph.D.
  • Master of Science
  • Bachelor of Science

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