Chief Technical Officer of VectorGen, a Biotechnology start-up dedicated to HIV cure research. Accomplished Laboratory Researcher with broad expertise in techniques of Cell and Molecular Biology. Experienced Grant Writer and Undergraduate Instructor in numerous Biological sub-disciplines.
Biochemistry, Cell Biology, Genetics, Molecular Biology
Coursework included: Genetics, Microbiology, Cell and Developmental Biology, Vertebrate Zoology, Mammalian Physiology, Molecular Biology, Immunology, Neurobiology, Neuropsychology,
Master's Thesis: A Replication-Competent, Auto-Inhibiting Vector for Gene Delivery. A survey of current vector technology. Arguments for developing a replication-competent viral-based vector especially for treatment of HIV infection. A description of the auto-regulatory mechanism, in which inhibition is conditioned on the eradication of the target virus.
Tested rodent serum for viral antigens for Taconic and Taconic clients in high through-put serology laboratory using ELISA assay. Independently assessed quality of results. Scheduled tasks to assure quality results obtained in a timely fashion.
Performed Blood Aggregation Assay to solve a critical issue for a product transitioning from Research & Development to a commercial product for GE Healthcare. Performed Flow Cytometry to establish levels of CD4-, CD25-, and CD19-positive cells among activated PBMCs. Utilized laboratory-scale and bioreactor-scale T-cell culture to develop improved devices for cell therapy.
Developed collaborations with researchers at Albany Medical College, Rensselaer Polytechnic Institute, and Imquest. Submitted SBIR and R21 grant applications to National Institute of Allergy and Infectious Diseases. Currently engaged in proof-of-concept research to validate auto-regulatory mechanism of gene delivery vector to combat HIV virus.
Candled chicken embryos to assay effectiveness of anti-tumor vascular inhibitors.
In Molecular Immunology Laboratory, utilized techniques of Mammalian Cell Culture, performed transfection by electroporation, analyzed calcium release in response to ligation of T-cell, or MHC Class II receptor, and screened transfectants with flow cytometer, for expression of Ia.2 and Ia.17 epitopes, to correlate presence of Ia.2 epitope with physiological state of K46mu T-cells.
•In Cognitive Neuroscience laboratory, performed High Density Electrical Mapping to study binocular interactions on monocularly deprived human subjects
•In Neuropharmacology laboratory, tested putative neuroprotectants for efficacy against effects of gestational cocaine exposure in rats. Utilized HPLC, cell harvester for receptor binding studies, liquid scintillator, rodent handling and dissection
•In Gene Therapy Laboratory, performed bacterial cloning and expression to generate poly-lysine construct for gene delivery. Utilized PCR, Western Blot, and autoradiography
•In Neuroscience Laboratory, used Confocal Photo-Microscopy to study distribution and localization of Presenilin. Experimentation involved mouse dissection, primary neuronal cell culture, fluorescence immunohistochemistry
1987 - Summer Undergraduate Research Fellowship for research in Immunology Laboratory at Columbia University
2000 - Five Year Fellowship for Graduate Research at Mt. Sinai School of Medicine
2005 - Five Year Fellowship for Graduate Research at The City University of New York - Graduate Center
2012 - Presentation of VectorGen's business plan to entrepreneurs at Startup New York. Discussion of VectorGen's ground-breaking genetic delivery system; advantages over vaccine approaches and current vector technologies.
2012 - VectorGen accepted for inclusion in Emerging Ventures Ecosystem at Rensselaer Polytechnic Institute
2008 - VectorGen accepted for inclusion in Business Development Incubator - New Jersey City University
2005 - New York Academy of Science
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