Mechanistic Insight into Desaturation Reactions by Two Fe(II)/2-oxoglutarate-dependent Oxygenases
*Poster presentation 2017 Metals in Biology Gordon Research Conference
Title: Mechanistic Insight into Desaturation Reactions by Two Fe(II)/2-oxoglutarate-dependent Oxygenases
*Oral presentation 2016 Biochemistry, Microbiology, and Molecular Biology Departmental Seminar
Title: Mechanistic Insight into Desaturation Reactions by Two Fe(II)/2-oxoglutarate-dependent Oxygenases
*Poster presentation 2016 Enzymes, Coenzymes, and Metabolic Pathways Gordon Research Conference/Seminar
Title: Substrate analogs enable diverse reaction outcomes in the iron and 2-(oxo)-glutarate-dependent hydroxylase VioC
*Poster presentation 2016 Metallocofactors Gordon Research Conference/Seminar
Title: Substrate analogs enable diverse reaction outcomes in the iron and 2 -(oxo)-glutarate-dependent hydroxylase VioC
*Poster presentation 2016 Joanne Stubbe 70th Birthday and Symposium
Title: Substrate analogs enable diverse reaction outcomes in the iron and 2 -(oxo)-glutarate-dependent hydroxylase VioC
*Poster presentation 2016 Pennsylvania State University Bioinorganic Chemistry Workshop
Title: Substrate analogs enable diverse reaction outcomes in the iron and 2-(oxo)-glutarate-dependent hydroxylase VioC
Publications
*Liu, Y., Miao, K., Dunham, N.P., Liu, H., Fares, M., Boal, A.K., Li, X., Zhang. The Cation-* Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification. 2017. Biochemistry. 56, 1585-1595.
*ACS Editor's Choice article
*Mitchell, A.J., Dunham, N.P., Bergman, J.A., Wang, B., Zhu, Q., Chang, W.-c., Liu, X., Boal, A.K. Structure-guided reprogramming of a hydroxylase to halogenate its small molecule substrate. 2016. Biochemistry. 56, 441-444.
Crystal Structures Solved
*X-ray crystal structure of Halotag bound to the P9 benzothiadiazole fluorogenic ligand
*PDB ID: 5UXZ
*X-ray crystal structure of apo Halotag
*PDB ID: 5UY1
Noah Dunham 2
