Enthusiastic Health Scientist with extensive project management experience, effective communication skills and extensive data analysis skills. Versed in study design, implementation and evaluation of research programs in molecular and genomics analyses. Proven dedication, productivity with a high impact publication record. Desires a challenging position as Microbiologist at ARS.
Diverse Research Experience (Microbiology, Genomic Analysis, Super Resolution Microscopy, Toxicology and Pharmacology), Data Analysis and Evaluation, Project Management, Grant Writing and Review, Organizational Skills, Strategic Planning, Communication Skills
College of Veterinary Medicine: Identification of key epigenetic mechanisms controlling accurate cell division in oocytes and pre-implantation embryos. Toxicological analyses of environmental factors leading to genome instability, aneuploidy and subfertility. Responsible for planning and execution of experiments, communication/presentation of research findings and management of research personnel and instruction of trainees/students. Developed novel molecular techniques for validation of pharmacological key targets for innovative epigenetic therapies.
School of Veterinary Medicine: Planned and executed studies identifying key epigenetic mechanisms controlling cell senescence, genome instability and malignant transformation. Generated animal models for the study of heterochromatin formation in oocytes, meiotic spindle assembly and accurate chromosome-microtubule attachments. Instructed veterinary students, research personnel and Summer students.
Center for Animal Transgenesis and Germ Cell Research: Efforts focused on determining the origins of chromosome aberrations and aneuploidies in female germ cells. Established and managed a cytogenetic service for veterinary karyotype analysis.
Institute of Pharmacology and Toxicology, Laboratory of Prof. Franz Theuring: Developed mouse models for target validation of novel non-hormonally acting contraceptives for male and female fertility control; Dissertation: “Generation and Characterization of knockout mice lacking MVDP protein” – 2004 Freie Universitaet Berlin, Germany
Cell and Tissue Culture:
Embryology (mouse, baboon, horse, dog, human):
University of Georgia, Athens, GA College of Veterinary Medicine co-instructing VPHY 8001 (graduate course) co-instructing VPHY 6000 (undergraduate course)
University of Pennsylvania, Kennett Square, PA School of Veterinary Medicine2009-2010 Co-Instructor, lab course on bovine reproduction and embryo sexing for veterinary students.
University of Heidelberg, Germany Institute of Human Genetics1998-1999 Teaching Assistant, responsible for teaching undergraduate level course "Human Genetics".
Graduate students: Payel Sil, PhD (PhD UGA 2017)Erica Noland, DVM (Georgia Veterinary Scholar's Program 2013), Xiaotian Wang (PhD 2020), Luhan Yang (PhD candidate), Sheree Deadrick (Georgia Veterinary Scholar's Program, 2018), Maru Orbay Cerrato (Georgia Veterinary Scholar's Program, 2019). Maddie Hinerfeld (Masters student 2020)
Undergraduate students: Wendi Bao (Medical Partnership University System of Georgia), Maddison Cunning (Medical College of Georgia), Gazal Aurora (Curo student), Ashley Lal (Curo student), Liza Roger (Summer Student, MD Emory Medical School 2016), Zachary Jones (Curo student)
Summer students: Christopher Daily - (PhD University of Illinois), Mariani Fiorenza - (Universidade Federal de Santa Maria, Brasil)
Research personnel: Jessica Koch - Research Assistant (Nursing Degree, UPenn), Muhan Hu - Research Assistant (MD/PhD program University of Birmingham), Charles Hall (Research Assistant, UGA Vet School class of 2018)
2005-present: Member, Society for the Study of Reproduction
2010-present: Fellowship committee member, Graduate Women in Science
Ad hoc Reviewer:
BMC Cancer, Molecular Reproduction and Development, Reproduction, Biology of Reproduction, Human Reproduction, Molecular and Cellular Biochemistry, Frontiers in Cell and Developmental Biology
Awards and Honorary Appointments:
Award of Excellence in Science, Science in Veterinary Medicine Symposium, (UGA 2010, 2011, 2015), Roundtable Coordinator, (University of Pennsylvania 2009-2010), Poster Prize, (University of Pennsylvania 2009) Public Speaking Award, (University of Pennsylvania 2006)Larry Ewing Travel Grant, (Society for Reproductive Biology, Omaha, Nebraska, USA 2006)Schering AG Travel Grant (Society for Reproductive Biology, Baltimore, MD,USA 2002)University of Heidelberg Travel Grant, (Qualitätsmanagement und Klassische Zucht (Genetik) – Detmold, Germany 1999)
Articles - peer reviewed:
NCBI/PubMed link: https://www.ncbi.nlm.nih.gov/myncbi/1leat75CY_GQU/bibliography/public/
1. Baumann C, Zhang X, De La Fuente R. Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements. J Cell Biol. 2020 Nov 2;219(11). doi: 10.1083/jcb.201910149. PubMed PMID: 32870972; PubMed Central PMCID: PMC7594495.
2. Baumann C, Ma W, Wang X, Kandasamy MK, Viveiros MM, De La Fuente R. Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis. Nat Commun. 2020 Sep 8;11(1):4486. doi: 10.1038/s41467-020-18009-3. PubMed PMID: 32900989; PubMed Central PMCID: PMC7478982.
3. Yang L, Baumann C, De La Fuente R, Viveiros MM. Mechanisms underlying disruption of oocyte spindle stability by bisphenol compounds. Reproduction. 2020 Apr;159(4):383-396. doi: 10.1530/REP-19-0494. PubMed PMID: 31990668; PubMed Central PMCID: PMC7032969.
4. Wang X, Baumann C, De La Fuente R, Viveiros MM. CEP215 and AURKA regulate spindle pole focusing and aMTOC organization in mouse oocytes. Reproduction. 2020 Mar;159(3):261-274. doi: 10.1530/REP-19-0263. PubMed PMID: 31895686.
5. Baumann C., Wang X., Viveiros MM. Error-prone meiotic division and subfertility in mice with ocyte-conditional knockdown of pericentrin. J Cell Sci. 2017 Feb;130(7).
6. Baumann C., Viveiros MM. Meiotic Spindle Assessment in Mouse Oocytes by siRNA-mediated Silencing. J Vis Exp. 2015 Oct 11;(104).
7. Ma W., Baumann C., Viveiros MM. Lack of protein kinase C-delta (PKCδ) disrupts fertilization and embryonic development. Mol Reprod Dev. 2015 Oct;82(10):797-808.
8. Baumann C., Olson M., Wang K., Fazleabas A., De La Fuente R. Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis. Reproduction. 2015 Oct;150(4):297-310.
9. El Zowalaty AE., Baumann C., Li R., Chen W., De La Fuente R., Ye X. Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility. Cell Death Dis. 2015 Jul 16;6:e1817.
10. De La Fuente R., Baumann C., Viveiros MM. ATRX contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo. Development. 2015 May 15;142(10):1806-17.
11. Pattabiraman S., Baumann C., Guisado D., Eppig JJ., Schimenti JC., De La Fuente R. Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability. J Cell Biol. 2015 Jan 5;208(1):53-69.
12. *Yang F., *Baumann C., Viveiros M.M., De La Fuente R. Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte. Int J Dev Biol. 2012;56(10-11-12):889-899. (*equal contribution)
13. Fayrer-Hosken R., Stanley A., Hill N., Heusner G., Christian M., De La Fuente R., Baumann C., Jones L. Effect of feeding fescue seed containing ergot alkaloid toxins on stallion spermatogenesis and sperm cells. Reprod Domest Anim. 2012; 47(6):1017-26.
14. *Zeng W., *Baumann C., Schmidtmann A., Honaramooz A., Tang L., Bondareva A., Dores C., Fan T., Xi S., Geiman T., Rathi R., de Rooij D., De La Fuente R., Muegge K., Dobrinski I. Lymphoid-Specific Helicase (HELLS) Is Essential for Meiotic Progression in Mouse Spermatocytes. Biology of Reproduction 2011 Jun;84(6): 1235-41 (*equal contribution)
15. Baumann, C. and De La Fuente, R.: A critical role of polycomb group protein CBX2/M33 in meiosis onset and maintenance of chromosome stability in the mammalian germline. Genes 2011 2, 59-80.
16. Baumann, C., Daly, C., McDonnell S., Viveiros, M., De La Fuente R.: Cohesin subunit SMC3 reveals a unique chromatin configuration and epigenetic landscape at the sex chromosome bivalent during equine spermatogenesis. Chromosoma 2011 120(3): 227-44.
17. Baumann, C., Viveiros, MM, De La Fuente, R.: Loss of maternal ATRX function results in centromere instability and a high incidence of aneuploidy in the mammalian oocyte and pre-implantation embryo. PLoS Genetics 2010. 6(9): e1001137.
18. Ma, W., Baumann, C., Viveiros, MM: NEDD1 is Crucial for Meiotic Spindle Stability and Accurate Chromosome Segregation in Mammalian Oocytes. Developmental Biology 2010 339(2): 439-50.
19. Vanderwall DK., Baumann C., Viveiros M., Sertich P., Kelleman A., Maenhoudt, C., Jacobson, C., and De La Fuente R.: Characterizing the meiotic spindle configuration and chromosome complement of in vivo matured equine oocytes. Anim. Reprod. Science 2010 Supplement 1 121(1-2):234-236.
20. Yang F, Baumann C., and De La Fuente R.: Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in Poly (ADP-ribose) polymerase (PARP-1) null oocytes. Developmental Biology 2009 331: 326-338.
21. Baumann C., De La Fuente R. ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells. Chromosoma 2009 118(2): 209-22.
22. Baumann C., Schmidtmann A., Muegge K., De La Fuente R. Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia. BMC Mol Biol. 2008 9: 29.
23. Baumann C., Davies B., Peters-Kottig M, Kaufmann U., Lessl M., Theuring F. AKR1B7 (Mouse Vas Deferens Protein) is Dispensable for Mouse Development and Reproductive Success. Reproduction. 2007 Jul;134(1):97-109.
24. De La Fuente R., Baumann C., Schmidtmann A., Dobrinski I., Muegge K. LSH is required for proper meiosis and transcriptional silencing of transposable elements in female germ cells. Nature Cell Biology 2006 8(12): 1448-54.
25. Yang F., De La Fuente R., Leu N.A., Baumann C., McLaughlin K.J., Wang P.J. SYCP2 Is Required for Synaptonemal Complex Assembly and Chromosomal Synapsis during Male Meiosis. J Cell Biol. 2006 May; 173(4): 497-507.
26. Davies B., Baumann C., Kirchhoff C., Ivell R., Nubbemeyer R., Habenicht U.F., Theuring F., Gottwald U. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol. 2004 Oct; 24(19): 8642-8.
Book Chapters & Review Articles:
1. De La Fuente R., Baumann C., Viveiros M.M.: Epigenetics in Human Reproduction and Development. Anna K Naumova, Teruko Taketo (eds.), World Scientific Publishing Co., Feb 2017, Chapter 2.
2. Baumann C., De La Fuente R., Viveiros M.M.: Oocyte Physiology and Development in Domestic Species: 1st Edition. R. Krishner (ed.) John Wiley & Sons. Ltd, London, U.K., 2013.
3. De La Fuente R., Baumann C., Viveiros MM. Chromatin structure and ATRX function in mouse oocytes. Results Probl Cell Differ. 1st Edition J. Kubiak (ed.) Springer, Berlin Heidelberg 2012;55:45-68.
4. De La Fuente R., Baumann C., Viveiros MM. Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease. Reproduction 2011, 142(2):221-34.
5. De La Fuente R., Baumann, C., Yang, F. and Viveiros M.M.: Chromatin Remodeling in Mammalian Meiosis. Oogenesis: The Universal process of Oogenesis: 1st Edition. M. H. Verlhac (eds.). John Wiley & Sons. Ltd, London, U.K., 2010.
Meeting abstracts and presentations:
1. Wang X., Baumann C., Yang L., Viveiros MM.: Cep215 is an Essential aMTOC-Associated Protein that Regulates Meiotic Spindle Organization in Oocytes. Society for the Study of Reproduction Annual Meeting, July 2018, New Orleans, LA
2. Yang L., Baumann C., Wang X., Viveiros MM. Bisphenol Compounds Destabilize Microtubules and Disrupt Meiotic Spindle Organization in Mouse Oocytes. Society for the Study of Reproduction Annual Meeting, July 2018, New Orleans, LA
3. Viveiros MM., Baumann C., Wang X., Yang L. Regulation of Meiotic Spindle Assembly and Stability in Oocytes. Society for the Study of Reproduction Annual Meeting, July 2017, Washington DC
4. Baumann C., De La Fuente R. Role of the chromobox protein CBX2 in chromosome stability during cellular senescence and malignant neoplastic transformation. Cold Spring Harbor Meeting on Epigenetics and Chromatin, Sept. 2012, Cold Spring Harbor, NY, USA
5. Baumann C., Yang F., De La Fuente R. Effects of HDAC inhibitor TSA on chromatin structure and function in female germ cells. Keystone Symposium - Environmental Epigenomics and Disease Susceptibility, March 2011, Asheville, NC, USA
6. Baumann C. and De La Fuente R. Loss of maternal ATRX function results in centromere instability and a high incidence of aneuploidy in the mammalian oocyte and pre-implantation embryo. Keystone Symposium - Frontiers in Reproductive Biology and Regulation of Fertility, February 2009, Santa Fe, NM, USA
7. Sertich P., Baumann C., Engiles J., Kelleman A. and De La Fuente R.: A case of X-chromosomal deletion in a high performance mare detected by fluorescence in situ hybridization (FISH). Penn Veterinary Medicine Retreat 2009, Philadelphia, PA, USA
8. Baumann C. and De La Fuente R. ATRX Marks the Inactive X Chromosome During Imprinted and Random X Chromosome Inactivation. Penn Institute for Regenerative Medicine Research Retreat on Stem Cells and Regenerative Medicine, October 2008, Philadelphia, PA, USA
9. Zeng W., Honaramooz A., Fan T., Schmidtmann A., Baumann C., De La Fuente R., Muegge K. , and Dobrinski I. Testis Tissue Allografting Reveals a Phenotype of Meiotic Arrest in Neonatally Lethal LSH KnockOut Mice. 2007, Biology of Reproduction
10. Baumann C. Independent Regulation of DNA Methylation and Histone Methylation in neonatal Mouse Spermatogonia. Annual Meeting of the Society for the Study of Reproduction, 2006, Omaha, Nebraska, USA
11. Baumann C. and De La Fuente R. Ontogeny of the chromatin remodeling protein ATRX and its potential interaction with death domain-associated protein (DAXX) during mouse spermatogenesis. Annual Meeting of the Society for the Study of Reproduction, 2005, Quebec, Canada
12. Baumann C., Davies B., Engelhaupt A., Lessl M. Peters-Kottig M., Seipp A. New targets for fertility control. IRM 2003, Schering AG, Berlin, Germany
13. Schroeckh V., Baumann C., Fricke S., Riesenberg D. Use of nitrogen stress for recombinant protein expression: modification of the nitrogen controlled glnA promoter. International Conference on Microbial Response to Stress: What's New and How Can It Be Applied? 1997; Sesimbra, Portugal
Job Titles Held: