- Experienced research scientist with a background in cellular radiobiology and cancer biology.
- Well-versed in both benchtop and translational research.
- Specialization in preclinical imaging techniques including PET/SPECT/CT, MRI, optical imaging as well as small animal irradiation.
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NIH Training Grant Awardee, Cancer Biology PhD Program, Wayne State University, Detroit, MI (2005-2007)
Radiation Research Society Scholar-in-Training Travel Award (2005, 2009)
Best Young Speaker, 2nd Symposium on Small Animal Radiotherapy, Vancouver, BC, Canada (2014)
Management of a preclinical imaging area that includes a PET/SPECT/CT, 3-Tesla MRI, a near-infrared optical imager and an image-guided small animal irradiator.
Provides oversight and guidance for the planning and execution of small animal projects in Radiation Oncology and other departments in research institute.
Performed a variety of laboratory research including:
- in vitro response of prostate cells to radiation and dietary supplements
- in vivo impact of chemotherapy and radiation therapy during hypobaric oxygen treatment
- in vivo damage response pathways in hematopoietic stem cells after whole-body irradiation
- in vivo role of bone marrow-derived progenitor cells after radiation-induced lung damage
Completed research in pursuit of Ph.D. in cancer biology.
performed an array of laboratory techniques including cell survival assays, cell and yeast irradiation, flow cytometry, immunoflorescence and cell growth assays.
Conducted experiments in breast cancer research lab.
Techniques included bacterial transfection, cell cloning, western blotting, drug testing and invasion assays with human cancer cells.
Radiation Research Society
American Association of Cancer Research
American Society for Radiation Oncology
World Molecular Imaging Society
Peer-reviewed Manuscripts
Rajaganapathy BR, Janicki JJ, Levanovich P, Tyagi P, Hafron J, Chancellor MB, Claire SA and Marples B. Intravesical Liposomal Tacrolimus protects against radiation cystitis induced by 3-beam targeted bladder irradiation. J Urol. 2015 Aug;194(2):578-84.
Wobb J, Claire SA, Kane J, Galoforo S, Grills IS, Wilson GD and Marples B. The effects of pulsed radiotherapy on tumor oxygenation in two murine models of head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2015 Jul 15;92(4).
Dilworth JT, Claire SA, Wilson GD, Marples B. Preclinical models for translational research should maintain pace with modern clinical practice. IJROBP 1;88(3):540-4, March 2014.
Schoenherr D, Claire SA, Martin L, Marignol L, Wilson GD, Marples B. Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: A cell line study in four glioblastoma multiforme (GBM) cell lines. IJROBP. 89(12):1009-16, December 2013.
Kane J, Claire SA, Dilworth JT, Torma JT, Wilson GD, Marples B, Madlambayan GJ. Hematopoietic stem and progenitor cell migration after hypofractionated radiation therapy in a murine model. IJROBP. 87(5):1162-70, October 2013.
Lee DY, Chunta JL, Park SS, Huang J, Martinez AA, Grills IS, Claire SA, Wilson GD, Marples B. Pulsed verse conventional radion therapy in combination with temozolomide in a murine orthotopic model of glioblastoma multiforme. IJROBP. 86(5):978-85, August 2013.
Dilworth JT, Claire SA, Dabjan M, Grills IS, Torma J, Wilson GD, and Marples B. Pulsed Low-Dose Irradiation of Orthotopic Glioblastoma Multiforme (GBM) in a pre-clinical model: Effects on Vascularization and Tumor Control. Radiother. Oncol. 2013 Jun 19.
Swanson TA, Claire SA, Galoforo S, Thibodeau BJ, Martinez AA, Wilson GD, Marples B. TMPRSS2/ERG fusion gene expression alters chemo- and radio-responsiveness in cell culture models of androgen independent prostate cancer. The Prostate, 2011 Mar 10.
Claire SA, Wilson GD, Piasentin E, Joiner MC and Marples B. (2010). The effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivity. IJROBP 1;77(5):1509-17.
Claire SA, Collis SJ, Joiner MC, Wilson GD and Marples B. (2007). The transition in survival response from low-dose hyper-radiosensitivity (HRS) to increased radioresistance is independent of ATM Ser1981 activity. IJROBP 15;69(4): 1262-71.
Claire SA, Joiner MC, Weinfeld M, Piasentin E and Marples B. (2007). Role of apoptosis in low-dose hyper-radiosensitivity. Radiation Research 167 (3): 260-267.
Books and Chapters
SA Claire and GD Wilson. Flow cytometric DNA analysis of human cancers and cell lines. Methods Mol Biol 731:359-70, 2011.
B Marples, SA Claire, SJ Collis and MC Joiner. Low-dose hyper-radiosensitivity: A historical perspective. In Targeted Radionuclide Tumor Therapy (T. Stigbrand et al., Eds.), pp. 329-347. Springer Netherlands, 2008.
Translational experimental design
Small animal surgery and injections
IACUC protocol writing and review
Preclinical image acquisition and analysis (PET/CT/MRI/optical)
Small animal CT-guided radiation treatment planning and treatment
Radioactive material handling, documentation and transport
Cell culture
Western blotting and other protein analysis techniques
Flow cytometry staining and analysis
Flow and magnetic cell sorting
Immunofluoresence and immunohistochemistry staining and analysis of tissue and cell samples
Scientific paper, grant and professional presentation preparation
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School Attended
- Wayne State University School of Medicine
- Wayne State University
Job Titles Held:
- Research Associate II
- Research Associate I, Department of Radiation Oncology
- Graduate Research Assistant, Cancer Biology Graduate Program
- Research Assistant, Department of Pathology
Degrees
- Ph.D.
- Bachelor of Science
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