LiveCareer-Resume

graduate research assistant resume example with 4+ years of experience

Jessica Claire
  • , , 609 Johnson Ave., 49204, Tulsa, OK 100 Montgomery St. 10th Floor
  • Home: (555) 432-1000
  • Cell:
  • resumesample@example.com
  • :
Summary
  • Graduate student pursuing PhD in Pharmaceutical Sciences at University at Buffalo (UB) in the field of pharmacokinetic/pharmacodynamic (PK/PD) modeling and antibody pharmacokinetics under the mentorship of Dr. Dhaval Shah.
  • Hands-on experience of using various pharmacometric softwares like ADAPT5, MATLAB (Simbiology), Berkeley Madonna, NONMEM, Phoenix (WonNonlin).
  • Can develop a diverse set of models including physiologically-based pharmacokinetic modeling (PBPK), minimal PBPK (mPBPK), PK/PD models, TMDD and population PK-PD models across different therapeutic areas.
  • A multifaceted and versatile scientist with laboratory experience in domains such as conducting in vivo PK studies in mice and rabbits, antibody production and purification using CHO cell line, protein quantification using analytical tools like ELISA, and LC-MS/MS.
Education
Ph.D: Pharmaceutical Sciences, Expected in 08/2025 to University At Buffalo - Buffalo, NY,
GPA:
Master of Science: Pharmaceutical Sciences, Expected in 08/2021 to University At Buffalo - Buffalo, NY,
GPA:

GPA: 3.81/4

Bachelor of Pharmacy: , Expected in 08/2019 to Institute of Chemical Technology - Mumbai,
GPA:

GPA: 7.55/10, Graduated with honors

Experience
Graduate Research Assistant, 07/2021 to Current
The New School, ,
  • Advisor: Dr. Dhaval Shah
  • Project title: Study the impact of charge and size of antibodies on ocular pharmacokinetics after systemic administration in rabbits.
  • Conducted pharmacokinetic studies in New Zealand White rabbits using trastuzumab.
  • Future studies involve conducting pharmacokinetic studies using anti-HER2 nanobody, single-chain variable fragment (scFv), +5 and -8 charged variants of trastuzumab.
  • The protein quantification in plasma and ocular tissues was done using Enzyme-linked immunosorbent assay (ELISA).
Master's Research-Thesis Project, 07/2019 to 07/2021
Signature HealthcareCoshocton, ,
  • Thesis Advisor: Dr. Dhaval Shah

1) Development of human and monkey ocular Physiologically-based Pharmacokinetic (PBPK) model for humanized, full-length antibodies.

  • Scaled-up the previously published rabbit-ocular PBPK model by finding datasets and values for various physiological parameters of the ocular compartment in literature.
  • The model was fit to the datasets using Berkeley Madonna and some of the ocular parameters using ADAPT and calculating SMAPE (symmetric mean absolute percentage error) between the Area under Curve (AUCs) of the observed and simulated pharmacokinetic profiles using PKNCA package of R-studios.
  • Manuscript submitted for publication.

2) Targeting Transferrin receptor (TfR) to improve ocular exposure of protein therapeutics.

  • Conducted pharmacokinetic studies in mice using trastuzumab and anti-transferrin mAb (F12) after systemic administration.
  • The protein quantification was conducted in plasma and ocular tissues using ELISA.
  • Future studies involve conducting PK studies using another anti-transferrin antibody (8D3) having stronger binding to the transferrin receptor.
Summer Intern, 04/2018 to 05/2018
Ferring Pharmaceuticals Pvt LtdCity, ,
  • Advisor: Dr. Dnyanesh Shelar
  • Area of emphasis: Semi-solid and solid dosage forms.
  • Studied the effect of various monovalent, divalent ions, and artificial urine on the viscosity of hydrogel, prepared by varying concentrations of gellan gum using the Brookfield viscometer.
  • Daily tasks involved performing in-process quality control tests such as tablet compression, weight variation, hardness, friability, disintegration test, dissolution testing using USP Type I and Type II apparatus etc.
  • Prepared summary of training experience gained and effectively presented to the supervisors.
Academic Intern, 04/2017 to 05/2018
Institute Of Chemical TechnologyCity, STATE,
  • Advisor: Prof. (Mrs.) P.D. Amin
  • Area of emphasis: Solid dosage forms.
  • Formulated tablets of cyanocobalamin (Synthetic Form of Vitamin B12) using absorption enhancers like chitosan, EDTA, sodium-lauryl sulfate to increase the permeability of cyanocobalamin across the intestinal membrane as it is a Biopharmaceutics Classification System (BCS)-class III drug having poor permeability across intestinal membranes and high solubility in water.
  • Scaled-up the formulation to 3000 tablets and performed in-process quality control (IPQC) tests like weight variation, thickness, hardness, disintegration time.
Skills
  • PKPD Modeling Software: NONMEM, ADAPT5, Berkeley Madonna, SimBiology, Phoenix WinNonlin
  • Analytical Tools: MS Excel, R-studios
  • Lab Techniques: LC-MS/MS, ELISA, SDS-PAGE, Gel electrophoresis, Flow cytometry, Nanodrop, Fluorescence Spectroscopy, Circular Dichroism
  • In vivo skills in mice and rabbit including restraining, handling, anesthesia and various injections like intravenous, intraperitoneal, subcutaneous.
  • In vitro skills include antibody production and purification using Chinese Hamster Ovary (CHO) cells using Chinese Hamster Ovary (CHO) cells.
Activities and Leadership Positions
  • Treasurer for Graduate Student Association (GSA) club, University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, 2022-2023.
  • Dean's Student Ambassador (DSA) Peer Mentor, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, 2020-2021.

By clicking Customize This Resume, you agree to our Terms of Use and Privacy Policy

Your data is safe with us

Any information uploaded, such as a resume, or input by the user is owned solely by the user, not LiveCareer. For further information, please visit our Terms of Use.

Resume Overview

School Attended

  • University At Buffalo
  • University At Buffalo
  • Institute of Chemical Technology

Job Titles Held:

  • Graduate Research Assistant
  • Master's Research-Thesis Project
  • Summer Intern
  • Academic Intern

Degrees

  • Ph.D
  • Master of Science
  • Bachelor of Pharmacy

By clicking Customize This Resume, you agree to our Terms of Use and Privacy Policy

*As seen in:As seen in: