Second Major: Spanish
Our lab recently patented a gene signature that detects loss of a tumor suppressor (REST) in ~20% of all breast cancers and causes a poorer patient prognosis. To understand why loss of REST causes a more aggressive disease, I utilized publicly available array data to determine changes in gene and protein expression. I used this data to form hypotheses about underlying molecular mechanisms causing enhanced tumor aggression. Using this approach, I have identified several mechanisms by which REST works through to enhance cancer cell growth, which will advance the future of personalized medicine.
Gunsalus K.T.W., Wagoner M., Meyer K., et al. Induction of Lin28 is Required for the Growth and Pathogenesis of RESTless Breast Tumors. Cancer Res. 2012. 72(13): 3207-16.
Squirrell J.M., Fong J., Ariza C., Mael A., Meyer K., et al. Endogenous Fluorescence Signatures in Living Pluripotent Stem Cells Change with Loss of Potency. PLoS One. 2012 7(8). DOI: 10.1371/journal.pone.0043708.
Speaker: Gordon Research Seminar, Mammary Gland Biology
"REST Induces IRS1 in breast cancer: A mechanism for increased tumor aggression."
Poster: American Association for Cancer Research
"Induction of Lin28 is required for the growth and pathogenesis of RESTless breast tumors."
Speaker: Wisconsin Dual Sports Riders Fundraiser for Breast Cancer
"Finding better treatment options in breast cancer."
Speaker: Molecular & Cellular Pharmacology Symposium
"Loss of REST reduces requirements for growth."
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