Hardworking scientist highly effective at conveying advanced topics in a relatable manner. Responsible and reliable with a friendly and outgoing manner. Enthusiastic researcher eager to contribute to team success through hard work, attention to detail and excellent organizational skills. Clear understanding of scientific theories and applied concepts and training in laboratory equipment. Motivated to learn, grow and excel in scientific research.
Excellent in reading, writing, and fluently speaking
The free-living nematode Caenorhabditis elegans (C. elegans) is a proven model organism for lipid metabolism research. C. elegans studies showed that chronic exposure to mercury (Hg) compounds induces neuron degeneration likely due to the increase in reactive oxygen species (ROS). Selenium (Se) is an essential trace element required for activation of many antioxidant enzymes that makes it capable of both decreasing deposition of Hg during co-exposure possibly due to the high affinity between Hg and Se and reducing the ROS level by activating antioxidant enzymes. This study focused on investigating Se protection effect mainly in the presence of Phenylmercury Acetate (PMA), and the use of C. elegans lipid profiling changes as a biomarker for environmental pollutants exposure. Chronic exposure to different concentrations of PMA results in animal death, which is reduced by co- exposure with Se. Results showed that exposure to PMA increases ROS levels in the nematodes in a concentration-depended manner. Also, Se exposure showed a positive relationship between ROS level and elevated Se concentration; while co-exposure to PMA and Se reduced the ROS level in the exposed C. elegans. The wild type C. elegans was used to investigate the effect of selenium on the lipid profile induced by exposure to the environmental pollutant Phenylmercury Acetate (PMA). Individual fatty acids showed differences in their relative percentage in treatment with PMA versus control and these differences were recovered in the presence of selenium. Based on quantitative analysis of the normalized fatty acids composition, it was found that polyunsaturated fatty acids were the most susceptible to change in the tested chemical. Triacylglycerols (triglycerides) profile changed due to the exposure by showing smaller or sometimes larger percentages in PMA treatment compared to the control. It was evident that the antioxidant Se was able to counteract the PMA effect and bring the triacylglycerols' profiling back to normal. The results provided evidence that lipid profiling can serve as a biomarker for exposure to environmental stressors.
Recent Caenorhabditis elegans studies showed that low, chronic exposure to MeHg induces DA neuron degeneration likely due to the increase in reactive oxygen species (ROS) with the reduction of SKN-1/Nrf2 gene expression or reduction of MRP-7 gene expression. Reduction in the transcription factor SKN-1 gene expression increases MeHg-induced animal vulnerability and DA neuron degeneration; additionally, reduction in the putative multidrug resistance protein MRP-7 gene expression increases the accumulation of cellular mercury (Hg) and MeHg-induces DA neuron degeneration. Accordingly, Se is capable of both decreasing deposition of Hg in neurons possibly due to the high affinity between Hg and Se that results in Hg binding to Se, and inhibiting MeHg-induced DA neuron degeneration and mitigating MeHg's neurotoxicity. My studies demonstrate that Se significantly blunted MeHg's effects and proved its safety and efficacy in ameliorating MeHg's neurotoxicity.
Seminars conducted in Texas Southern University:
From 2015 to 2018:
1. Metabolism and Toxicity of Benzene
2. Metabolism and Toxicity of Tetrahydrocannabinol
3. Metabolism and Toxicity of Warfarin
4. Metabolism and Toxicity of Methadone
5. Metabolism and Toxicity of Nicotine
6. Metabolism and Toxicity of Polycyclic aromatic hydrocarbons
7. Characterization of the effects of selenium on methylmercury-induced toxicity in C. elegans (ETOX Seminar series)
Funding and Awards:
Certificate of Participation in the volunteer homeless program for 27+ hours Father Joe's Villages, San Diego,CA
May 2011 – March 2012
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