driven research scientist with broad exposure in preclinical drug
discovery. Have the stamina to run marathons and perseverance to meet milestones. Enjoy leading multi-disciplinary project
teams from target identification and validation through to candidate
selection. Opportunistic by nature, I enjoy thinking of applications
for new technology and partnering for mutual benefit.
skills include structure-based drug design, protein biochemistry, and
molecular biology. Analytic experience includes solving protein
structures, virtual compound design and screening, triaging
high-throughput screening data, assessing enzyme panels.
Rational drug design
to Current GlaxoSmithKline Inc – Research Triangle Park,
project teams in the metabolic and anti-viral therapeutic areas to deliver candidate compounds within specified timelines.
Visualized macromolecular complexes at atomic resolution for knowledge-based design. Provide translational validation using biochemistry and biophysics
Performed chemical modeling, data mining, and virtual screening techniques to identify leads, optimize existing chemical series, and to design novel chemotypes
Provide high-throughput structural analysis and enzyme design for Synthetic Biochemistry
- delivered engineered enzymes for improved API synthesis route
Developed scalable, high-throughput analysis protocols for Synthetic Biochemistry enzyme panel development Initiated RTP Chemical Biology and Biotechnology Symposium to network academic and industrial scientists and provide industrial exposure to biotechnology students at neighboring universities
Triaged primary-cell HTS data using statistical and chemoinformatic analysis
Initiated collaborations with academic experts in the U.S. and E.U. to jump start membrane protein biochemistry at GlaxoSmithKline.
Postdoctoral Research Associate06/1994
to 06/1998 Howard Hughes Medical Institute Yale University – New Haven,
Determined the three-dimensional structure of progesterone receptor with bound progesterone demonstrating atomic mechanism of steroid-based gene activation.
Postdoctoral Research Associate12/1989
to 05/1994 State University of New York Brookhaven National Lab – Stony Brook Upton,
Used biophysical techniques to correlate substrate and co-factor binding with viral protease activity.
Collaborated in development of tuned X-ray imaging, mapping the distribution of chemical components in biological samples.
Scientist/ManagerBioMolecular Structure Group
Ph.D.: Biophysics1989University of Michigan-
MIDetermined the structure of the chromatin 30 nM fiber using small-angle X-ray scattering, wide-angle X-ray scattering, biochemistry, and electron microscopy.
Advisor: John Langmore
Bachelor of Arts: Physics1982Temple University-
PA1982 Outstanding Achievement Scholar