Over 10 years of research experience in Synthetic organic chemistry, development of new synthetic methodologies, Synthesis of PAHs, Transition metal catalysis, synthesis of carbocycles and heterocycles including analytical techniques such as NMR, FT-IR, HPLC, MALDI, GC, UV, PL for characterization and structural elucidation of organic compounds and four years of industrial experience in Organic Research & Development at Sailifesciences; GVK-Bio; Chembioteck. To secure a scientist position in a prominent research group that utilizes my skills in multistep target-oriented organic synthesis offering me challenges and opportunity to advance my career.
http://pubs.acs.org/doi/abs/10.1021/ja510563d ) The first example of a traceless directing group in a radical cascade.
The chemo- and regioselectivity of the initial attack in skipped oligoalkynes is controlled by propargyl OR moiety.
Radical translocations lead to the boomerang return of radical center to the site of initial attack where it assists to the elimination of the directing functionality via b-scission in the last step of the cascade.
The Bu3Sn moiety allows further via facile reactions with electrophiles as well as Stille and Suzuki cross-coupling reactions.
This selective radical transformation opens a new approach for the controlled transformation of skipped oligoalkynes into polycyclic ribbons of tunable dimensions.
Synthesis of 9-Substituted Phenanthranes through regioselective radical cyclization of O-Phenylethynyl biphenyls.
Kamalkishore Pati, and Prof.
submitting to Org.
The synthesis of polyaromatic hydrocarbons (PAHs) has been both a passion and an attraction for synthetic chemists since the earliest beginnings of modern organic chemistry.
Phenanthrenes are an important class of polycyclic aromatic compounds and generally appear in many natural products and biologically active molecules with antimicrobial, anticancer, and anti-HIV activities.
Moreover, phenanthrene is an important structural motif in materials science due to its optical and electronic properties.
Symposia Attended: International Conference on Functional Organic Materials and Related Devices, National Tsing-Hua University, Hsinchu, Taiwan, June16-17 2012.
NTHU-KAIST-KYOTO University (N-K-K) Symposium National Tsing Hua University in Hsinchu, Taiwan, 2008.
Medicinal Chemistry Transition metal catalyzed organic transformations Total synthesis of biologically active natural products Development of novel synthetic methodologies Radical cascades Drug process development Synthesis of PAHs nanoribbons and Studies of photo physical properties Professional and Technical Skills: Expertise in target-oriented multistep organic synthesis.
Proficient in performing cryogenic reactions, Glove-box handling of air and moisture sensitive reagents and reactions.
Efficient in carrying out organic transformations on milligram to multigram scale.
Efficient in carrying out organic transformations Lab scale to Plant scale.
Educated in purification techniques such as distillation, crystallization, sublimation, column chromatography, MPLC and HPLC.
Competent in characterization of organic compounds using spectroscopic techniques such as 1H and 13C NMR, 2-D NMR (COSY, NOESY), IR and Mass.
Confident user of GC, UV , PL, MALDI, IR , NMR (Bruker AV-400, 600 and Varian-400, 500Hz) and M.
apparatus (Büchi B-540).
Good experience in searching the various scientific databases using Scifinder Scholar, Beilstein and ISI Web of knowledge.
Well versed with word processor software both on Windows and Macintosh platforms, and various chemistry related software packages e.g.
Chem Draw, ISIS draw, i-NMR, PC model to name a few.
Honors and Fellowships: Awarded Outstanding Research Fellowship by National Tsinghua University (N.T.H.U), Taiwan (20102011).
Awarded Research Fellowship by Ministry of Education, Taiwan (2007-2011).
Awarded Excellent Performance Fellowship by GVK-Bio Sciences, Hyderabad, India 2006.
Awarded Best safety Follower by GVK-Bio Sciences, Hyderabad, India 2005.
Working as Reviewer for several scientific journals.
Research Publications: Shear-Induced Long-Range Uniaxial Assembly of Polyaromatic Monolayers at Molecular Resolution.
Chen,*, C.W Li, Kamalkishore Pati, and R.S.
2008, 130, 1045410455.
Synthesis of functionalized dibenzo[g,p]chrysenes via tandem ICl-promoted cyclization of bis(biaryl)acetylenes and Pd-catalyzed annulation of the resulting 9-iodophenanthrene intermediates.
A convenient Synthesis of Tetrabenzo[de,hi,mn,qr]Naphthacene from Readily Available 1,2Di(phenanthren-4-yl) ethyne.
M, Kamalkishore Pati, and R.S.
2009, 74, 63116314.
A convenient synthesis of tetrabenzo [de,hi,mn,qr] naphthacene from readily available 1,2-di(phenanthren- 4-yl)ethyne via Bronsted acid catalyzed hydroarylation and FeCl3 oxidative coupling Shear-induced uniaxial assembly of polyaromatic monolayers Shern-Long; Chi, Cher-Yi Jason; Huang, Min-Jie; Chen, Chun-hsien; Li, Chia-Wen; Pati, Kamalkishore; Liu, Rai-Shung e-Journal of Surface Science and Nanotechnology (2009), 7, 157-160.
Efficient Catalytic Syntheses of -Pyridones and 3(2H)-Isoquinolones through Ruthenium- Catalyzed Cycloisomerization of 3-En-5-ynyl and O-Alkynylphenyl Nitrones.
Kamalkishore Pati and Rai-Shung Liu* Chem.Commun., 2009, 41, 5233-5235.
A new catalytic synthesis of a-pyridones and 3(2H)-isoquinolones from readily available 3-en-5-ynyl nitrones and o-alkynylphenyl nitrones; the reaction mechanism is proposed to involve iminyl ketene species through an oxygen transfer process.
Gold-Catalyzed Oxidative Ring Expansions and Cleavages of Alkynylcyclopropanes by Intermolecular Ph2SO-oxidation Reactions.
Li, Kamalkishore Pati, G.Y.
Lin, S.M Sohel, H.H.
2010, 49, 9891-9894.
A novel gold-catalyzed oxidative ring-expansion of unactivated cyclopropylalkynes using Ph2SO as an oxidant.
This catalysis enables the generation of a ketone group at the alkynyl carbon atom in a regioselective manner, accompanied by expansion of a cyclopropyl ring.
Crossover experiments exclude the participation of gold acarbonylcarbenoid intermediates.
For substrates bearing an electron-donor group at the cyclopropane ring, our preliminary results reveal a distinct cyclopropane cleavage arising from the Ph2SO oxidation of the alkyne functionality.
Such a ring-cleavage is further applicable to the synthesis of 2H-pyrans.
Ag(I)-Catalyzed Carbon-Carbon Bond Formation between a Ketone and an Allylic C-H Bond Kamalkishore Pati and R.S.
Liu* Chem.Commun, 2012, 48, 6049-6051.
Silver-catalyzed cyclization of 1-(2,2-dimethylcyclopropyl)methyl ketones to give 1,2,4-trisubstituted benzenes.
These reactions comprise an initial cyclopropane cleavage, followed by an aromatization of the resulting 4-en-1-one intermediate.
The latter represents an unusual silver-catalyzed addition of a ketone to an allylic CH bond via a non-carbonyl ene reaction.
Gold-Catalyzed Synthesis of Substituted 2-Aminofurans via Formal [4+1]-Cycloadditions on 3-En- 1ynamides.
R .Dateer, kamalkishore Pati and R.S.Liu, Chem.
Commun., 2012, 354, 2241-2250.
New gold-catalyzed [4+1]-cycloadditions between 3-en-1-ynamide and 8-methylquinoline oxide.
The success of this reaction relies on a hypothetic oxa-Nazarov cyclization on gold-stabilized allylic cation.
Preliminary results on a new 1,2-difunctionalization of 3-en-1-ynamide are also reported.
Oxy Effects on the Platinum-catalyzed Carbo- and Oxacyclizations of 2-Oxiranyl-1- (1'-oxyalky- 2ynyl)benzenes.
K.Pawar, Kamalkishore Pati and R.S.
2012, 354, Pt-catalyzed protocols for the synthesis of carbocycles and oxacycles from 2-oxiranyl-1-(1-oxyalk-2-ynyl) benzenes.
For 1,2,2-trisubstituted epoxides bearing an acyloxy group, their platinum-catalyzed cyclizations proceed through an initial 1,3-acyloxy shift, followed by an intramolecular attack of an allenyl acetate at the carbonyl group, ultimately giving 2-naphthyl ketones through a selective 1,2-alkyl shift.
1,1Disubstituted epoxides bearing a siloxy group undergo an oxacyclization to give bicyclic ketals with high diastereosele- ctivity.
GVK-Bio- MCLJanuary 2005 to January 2007Senior Research Associate
Synthesis of anti-cancer, other Drug Molecular Libraries (Heterocyclic analogs, Bisindole malemide analogs and.
peptide analogs and lead a 5 member research team).
CHEMBIOTEK RESEARCH INTERNATIONAL (P) LTD)January 2004 to January 2005Research Associate
Synthesis of Molecular Libraries for drug discovery program (Heterocyclics, and peptides).
SAI LIFE SCIENCES (P) LTD)January 2002 to January 2004Research Chemist
Drug process development (Clopidogrel bisulfate), Synthesis technology transfer (lab scale to pilot plant and plan scale synthesis (levetiracetam).
Florida State University National Tsinghua UniversityNovember 2012Doctor of Philosophy: Organic ChemistryTallahassee Hsinchu, FL, USA TaiwanPost-doc : Jan 2013 to present
Advisor : Prof. Igor. V. Alabugin Prof. R.S.Liu Organic Chemistry
National Tsinghua UniversityJuly 2011Hsinchu, TaiwanAdvisor : Prof. R.S.Liu
Thesis Title : Synthesis of Dibenzo[g,p]chrysenes and Tetrabenzo[de,hi,mn,qr]Naphthacenes Baring various
Functionalities & Transition Metal Catalyzed organic Transformations School
SRTM university Santhiniketan Degree College2000Bachelor of Science: Chemistry Chemistry and Bio-chemistryIndiaChemistry Chemistry and Bio-chemistry
Exo-Dig Radical Cascades of Skipped Enediynes: Building a Naphthalene Moiety within a Polycyclic Framework. Kamalkishore Pati, Audrey M. Hughes, Hoa Phan, Prof. Igor V. Alabugin* Chem. Eur. J. 2014, 20, 390-393. Cascade radical transformations of acyclic precursors open efficient, convenient and atom-economical access to functionalized compounds of increased structural complexity. This report describes a selective sequence of 5-exo-dig and 6-exo-dig cyclizations followed by attack at a pendant aromatic moiety and rearomatization. The overall transformation is a new approach for building a naphthalene moiety within a polycyclic framework. Furthermore, the high efficiency for the key 6-exo-step of the cascade paves the way for the preparation of defect-free graphene nanoribbons. Synthesis of Substituted Biaryls through Gold-Catalyzed PetasisFerrier Rearrangement of Propargyl Ethers. Kamalkishore Pati*, and Prof. Igor V. Alabugin* E. JOC. 2014, 19, 3986-90. Au-catalyzed sequence of alkoxy group translocation, Petasis-Ferrier rearrangement and aromatization transforms aryl propargyl ethers into substituted biaryls with functionalized naphthalene core. Traceless Directing Groups in Radical Cascades: From Oligoalkynes to Fused Helicenes without Tethered Initiators. Kamalkishore Pati, Gabriel dos Passos Gomes, Trevor Harris, Audrey Hughes, Hoa Phan, Tanmay Banerjee, Kenneth Hanson and Igor V. Alabugin. (JACS ASAP