I worked for the past 6 years at an environmental consulting firm as an environmental scientist and toxicologist. My areas of interest and expertise include toxicological consultation including hazard identification and dose-response analysis for the development of health-based criteria for human health and ecological receptors. I have experience reviewing and evaluating toxicity data relating to the degree of hazard associated with contaminants and natural toxicants present or entering the food supply, as well as those in soil, sediment, surface water, groundwater, and air. I have worked with other agencies or clients to discuss regulatory requirements and controversial technical and scientific points. I have experience in federal and state regulatory compliance and Phase I Environmental Site Assessments (ESAs). I have conducted exposure and toxicological assessments of chemicals in consumer products, such as personal care and cosmetic products, and performed human health and environmental risk assessments of product and fragrance formulations under the EPA Design for the Environment program. I managed project teams, analyzed environmental data, and conducted ecological and human health risk assessments in accordance with state and federal regulations. I have performed statistical analyses, evaluated human exposures, generated graphical presentations, and wrote reports to summarize my findings. I have been an environmental and toxicological consultant for the past 9 years.
Bradley, A.E., J.L. Shoenfelt, and J.L. Durda. 2016. Carcinogenicity and mode of action evaluation for alpha-hexachlorocyclohexane: Implications for human health risk assessment. Regul. Toxicol. Pharmacol. 76(2016):152-173.
Shoenfelt, J., R.J. Mitkus, R. Zeisler, R.O. Spatz, J. Powell, M.J. Fenton, K.A. Squibb, and A.E. Medvedev. 2009. Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter. J. Leukoc. Biol. 86(2):303-12.
Medvedev, A.E., W. Piao, J. Shoenfelt, S.H. Rhee, H. Chen, S. Basu, L.M. Wahl, M.J. Fenton, and S.N. Vogel. 2007. Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance. J. Biol. Chem. 282(22):16042-16053.
Shoenfelt, J.L., and M.J. Fenton. 2006. TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-*-independent. J. Endotoxin. Res. 12(4):231-240.
Keay, S., C.O. Zhang, J.L. Shoenfelt, and T.C. Chai. 2003. Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis. Urology 61(6):1278-1284.
Zhang, C.O., Z.L. Li, J.L. Shoenfelt, C.Z. Kong, T.C. Chai, D.R. Erickson, K.M. Peters, E.S. Rovner, and S. Keay. 2003. Comparison of APF activity and epithelial growth factor levels in urine from Chinese, African-American, and White American patients with interstitial cystitis. Urology 61(5):897-901.
Keay, S.K., C. Zhang, J.L. Shoenfelt, D.R. Erickson, K. Whitmore, J.W. Warren, R. Marvel, and T. Chai. 2001. Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis. Urology 57(6 Suppl. 1):9-14.
Chai, T.C., C.O. Zhang, J.L. Shoenfelt, H.W. Johnson Jr., J.W. Warren, and S. Keay. 2000. Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis. J. Urol. 163(5):1440-4.
Presentations/Posters: Shoenfelt, J., M.H. Whittaker, A.M. Gebhart, and F. Hammer. 2007. Derivation of a drinking water action level for tris(monochloropropyl) phosphate isomers. Society of Toxicology 2007 Meeting Abstract. Accepted for presentation at the 2007 SOT Meeting, Charlotte, NC. (Abstract 1552). June 2016
•Develop health-based toxicity criteria using EPA's benchmark dose modeling software and data from literature
•Provide toxicological consultation regarding the fate, transport and toxicological effects of environmental pollutants, munitions related constituents, emerging contaminants and hazardous materials on vertebrate biological systems
•Predict adverse effects from occupational and environmental exposures using risk assessment methods
•Project team management involving delegation of work and tracking of budget
•Develop site-specific cleanup levels for various receptors and exposure scenarios
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