AAV-mediated
RLBP1 gene therapy improves the rate of dark adaption in Rlbp1 knockout mice.
Molecular Therapy - Methods &
Clinical Development
Vivian Choi, Chad Bigelow, Terri McGee, Akshata Gujar, Hui Li, Shawn Hanks,
Joanna Vrouvlianis, Michael Maker, Barrett Leehy, Yiqin Zhang, Jorge Aranda,
George Bounoutas, John Demirs, Junzheng Yang, Richard Ornberg, Yu Wang, Wendy
Martin, Kelly Stout, Gregory Argentieri, Paul Grosenstein, Danielle Diaz,
Oliver Turner, Bruce Jaffee, Seshidhar Police, and Thaddeus Dryja
Characterizing kidney and eye pathology of complement
factor H deficient mice
Sha-Mei Liao, Natasha
Buchanan, John Demirs, Karen
Anderson, Bruce D.
Jaffee
Molecular
Immunology - MOL IMMUNOL. 01/2010; 47(13):2281-2281.
Pharmacologic uncoupling of angiogenesis
and inflammation during initiation of pathological
corneal neovascularization.
Journal Biological Chemistry. 2011 Dec
30;286(52):44965-75. Epub 2011 Nov 9.
Sivak JM,
Ostriker AC,
Woolfenden A,
Demirs J,
Cepeda R,
Long D,
Anderson K,
Jaffee B.
Department
of Vision Sciences, Toronto Western Hospital, Toronto, Ontario M5T 2S8
Real-time
In-Vivo Quantification of Melanocytes by Near-infrared Reflectance Confocal
Microscopy in the Guinea Pig Animal Model
Journal of
Investigative Dermatology 2002 119, 533–535
Wang
T, Demirs J, Pathak M, Gonzalez S.
Wellman
Center for Photomedicine, Harvard School of Medicine, MGH Boston Ma
Protein
Kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation
Oncogene. 2001 Oct 11;20(46):6764-76
Zhuang
S, Demirs J, Kochevar IE.
Wellman
Center for Photomedicine, Harvard School of Medicine, MGH Boston Ma
P38
Mitogen-activated protein kinase mediates Bid Cleavage, mitochondrial
dysfunction, and caspase-3 activation during apoptosis induced by singlet
oxygen, but not by hydrogen peroxide
Journal Biological Chemistry.
2000 Aug 25;275(34):25939-48
Zhuang S, Demirs J, Kochevar IE.
Wellman
Center for Photomedicine, Harvard School of Medicine, MGH Boston Ma
NIBR Global Research conference Posters:
Development
of a mouse model of geographic atrophy: Madrid Research Conference
M.E. McLaughlin, C. E. Bigelow, G. Bounoutas, N.
Buchanan, I. L. Jones, S. Poor, Demirs J., B. Jaffee
Department of Ophthalmology, Novartis Institutes for
Biomedical Research, Cambridge, MA USA
Inhibition
of Angiogenesis in a Murine laser-induced Choroidal Neovascularization Model: Madrid Research Conference 2009
Poor
S, Qiu Y, Demirs J, Anderson K, Jaffee B
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Investigation
into the Relationship between Tyrosine Kinase-EphA2 Expression levels, UVB
Exposure and Melanoma Cell Behavior
Zhang G, Yang G, Demirs J, Flores E, ChenYC, Hocker T,
Tsao H.
Wellman
Center for Photomedicine, Harvard School of Medicine, MGH Boston Ma
Posters:
ARVO:
(Association for Research in Vision and Ophthalmology)
Residual
Cesium Chloride in AAV Vectors Purified by CsCl Gradient Centrifugation Does
Not Cause Obvious Inflammation or Retinal Degeneration in C57Bl6/J Mice
Following Subretinal Injection
Guerin, Karen and Choi, Vivian and Aranda, Jorge and Demirs, John and Li, Hui and Yang, Junzheng and Nguyen, Niem and Bottega, Steve and Jaffee, Bruce and Dryja, Ted and Police, Seshidhar
Complement
Plays A Minor Role In Mouse Laser-induced Choroidal Neovascularization
Stephen
H. Poor, Elizabeth Fassbender, Siyuan Shen, Yubin Qiu, Amber
Woolfenden, John Demirs, Karen Anderson, Bruce D. Jaffee.
Ophthalmology,
Novartis, Cambridge, MA.
Low-grade
Ocular Inflammation Is Chronically Present in Complement Factor H-deficient
Mice
Natasha Buchanan, John
Demirs, Steve Louie, Sassan Azarian, Karen Anderson, Bruce Jaffee, Sha-Mei
Liao. Ophthalmology, Novartis Institutes for Biomedical Research,
Cambridge, MA; Genetics, Genomics
Institute of the Novartis Research Foundation, San Diego, CA
Gentamicin-Induced
Retinal Degeneration in Dutch Belted Rabbits
Delgado
O. Demirs J. Bigelow C. Poor S. Zhang Y. Louie S. Crowley M. Hanks S. Buchanan
N. Dryja T. Jaffee B. Liao S.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Activation
of the Wnt Pathway in a Mouse Corneal Neovascularization Model (ConV)
Azarian
S. Cepeda R. Liu J. Pan S. Nicholas N. Etmad-Gilbertson B. Giza S. Demirs J.
Anderson K. Elliot J. Kansara v. Long D. Drew T. Gould T. Brown A. Jaffee B.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Inhibition of angiogenesis in the Murine
laser-induced Choroidal Neovascular
Poor
S, Qiu Y, Demirs J, Anderson K, Jaffee B
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
A Rodent Model for Identifying Oral VEGFR2
Inhibitors as a Treatment for Wet Macular Degeneration
Poor
S, Qiu Y, Demirs J, Anderson K, Jaffee B
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Pseudo-AMD
Changes in Wild-type C57BI/6 Mice
N.M.
Buchanan, C.E. Bigelow, S.H. Poor, Demirs J., G.S. Bounoutas , I.L. Jones , B.
Jaffee, M.E. McLaughlin
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Lipid
Deposits, Retinal Pigmented Epithelium Dysfunction and Photoreceptor Degeneration:
An Acute Rat model of Dry Age-Related macular Degeneration
Y. Zhang, A. De Erkenez, S. Hanks, K. Anderson, Demirs J.,
J. Jaffee
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Lipid
deposits, retinal pigment epithelium dysfunction and photoreceptor
degeneration: An acute rat model of dry age-related macular degeneration
Zhang Y, De Erkenez A, and Demirs J.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Complement
activation and inflammation response in a rat model of NaIO3-induced RPE
degeneration.
De
Erkenez A, Anderson K, Demirs J, Zhang
Y.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Acute
light-induced photoreceptor damage in mice dependent upon strain and exposure
time.
Hanks
S, Bigelow C, Stefanidakis M, Demirs J, Jones I, Liao S, Jaffee B.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Structural
and functional changes in the mouse retina elicited by blue light exposure.
Hanks,
Shawn M., Michael Stefanidakis, Demirs J., Ian L. Jones, Sha-Mei Liao, Bruce D.
Jaffee, and Chad E. Bigelow.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA (ARVO Annual Meeting 2010)
A
Mouse Corneal Debridement Model Reveals Signaling Between Inflammatory
Infiltrates and Wound-Edge Epithelium to Induce a Neovascular Response.
Sousa,
Debby, Rosemarie Cepeda, Amber Woolfenden, Allison Cherry, Demirs J., Bruce Jaffee, Jeremy Sivak.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA, (ARVO Annual Meeting 2010).
Characterizing
Kidney and Eye Pathology of Complement Factor H Deficient Mice
Liao
S, Buchanan N, Demirs J, Anderson K, Jaffee Bruce.
Department
of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA
USA
Characterizing
Eye and Kidney Pathology of Complement Factor H-Deficient Mice
N.M.
Buchanan1, Demirs J.1, S. Louie1, S. Azarian2,
K. Anderson1, B.D. Jaffee1, and S-M Liao1, 1Ophthalmology, Novartis Institute
for Biomedical Research, Cambridge, MA, 2Genetics, Genomics
Institute of the Novartis Research Foundation, San Diego, CA
