Postdocoral Fellowship Resume Example
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POSTDOCORAL FELLOWSHIP
Personal Information
DOB: April, 22 1986
Driving Licence holder
Professional Summary
I have
a broad background in molecular and cell biology, with specific training and
expertise in cell adhesion
molecules a key research area for my current
lab. As a graduate student in Dr. Eric Villard's lab at INSERM
UMR 956, Paris, I studied the molecular and
cellular mechanisms of the Arrhythmogenic Right Ventricular
Cardiomyopathy (ARVC). ARVC is a rare
cardiomyopathy associated with fibro-fatty replacement, arrhythmia
and sudden death but can also be associated with
palmoplantar keratodermia and woolly hair in some case (called Naxos disease
and Carvajal syndrome). This pathology is the consequence of
mutations in genes encoding desmosomal proteins.
My first objective was to identify a specific signature
of junctional protein expression on a collection of ARVC
heart explants. During this work, I was
specifically interested in Desmoglein-2 (DSG2), a desmosomal
cadherin,
which is dramatically decreased in these patients. Therefore, my second
objective was to study the
mechanism(s) by which specific DSG2 mutations
lead to a severe ARVC phenotype. These mutations have the
capability to inhibit the propeptide cleavage,
which are associated with a complete loss of interaction in
classical cadherins. In this study, I have shown that
these DSG2 mutations don't affect the cadherin function in
normal culture condition. However, these
mutations exhibit a phenotype during mechanical stretching and
strongly affect the desmosome structure. I also, as a parallel
study, to identify new genetic cause to the disease by genes candidates approach on a population of
ARVD/C probands.
During my Ph.D. I was in charge of developing this
project, which was a new research area in the laboratory. I
acquired experience in growing cardiomyocytes
under stress conditions (Hydrogels/mechanical stretch) and a
large panel of molecular biology techniques. I
joined Dr. Glenn Radice's lab in the Center for Translational
Medicine to expand on my previous experience
in molecular cardiology with training in mouse molecular
genetics, cell biology, and cardiac
physiology. I am investigating the role of the cytoskeletal linker proteins
a-catenins in normal cardiac development and
injury response. I have the expertise and motivation necessary to
successfully carry out my knowledge.
Work History
Postdocoral Fellowship, 05/2013 to Current
University Of Kansas Medical Center – Larned , KS
University Of Kansas Medical Center – Larned , KS
- Subject: Role of cytoskeletal tension in the regulation of Yap activity in the
heart
PhD Student, 01/2009 to 01/2013
Bickford Senior Living – Muscatine , IA
Bickford Senior Living – Muscatine , IA
- Subject: Study of molecular and cellular mechanisms involved in Arrhythmogenic Right Ventricular Cardiomyopathy
Master 2 work experience., 01/2009 to 07/2009
University Pierre And Marie Curie – City , STATE
University Pierre And Marie Curie – City , STATE
- Subject: Research of a molecular signature in explanted arrhythmogenic right ventricular cardiomyopathy patient hearts
Master 1 work experience., 04/2008 to 07/2008
Unité INSERM U582 - Institut Of Myology, Hôpital Pitié Salpêtrière – City , STATE
Unité INSERM U582 - Institut Of Myology, Hôpital Pitié Salpêtrière – City , STATE
- Subject: Study of OPA1 mutations in autosomal dominant optic atrophy.
Unité INSERM U582 - Institut Of Myology, Hôpital Pitié Salpêtrière
Education
Ph.D.: Molecular and cellular mechanisms of Arrhythmogenic Right Ventricular Cardiomyopathy, March 2013
Pierre and Marie Curie University - City, State
Pierre and Marie Curie University - City, State
- Recipient of Ph.D Ministerial Scholarship (2009)
Master of Science: Physiology/Physiopathology, 2009
Pierre and Marie Curie University - City, State
Pierre and Marie Curie University - City, State
Bachelor of Science: Biology, June 2007
Université Paris VI - City, State
Université Paris VI - City, State
High School Diploma: June 2004
Fenelon - City, State
- Scientific Baccalaureate
Fenelon - City, State
- Scientific Baccalaureate
Teaching experience
- 2015-2016: Tutor for Chemestry labclass for Post-baccalaureate students. Thomas Jefferson University, Philadelphia, PA, USA
- 2010-2012: Biology tutor for licence grade. University Pierre and Marie Curie, Paris, France
- 2004-2008: Tutor in mathematics (High school). Fenelon, Vaujours, France
Skills
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Publications
- Alexia Vite, Jifen Li, Roslyn Yi, Ludovic Gomez, and Glenn L. Radice. Alpha-Catenin Regulated Cytoskeleton Tension Controls Yap Activity in Cardiomyocytes. 2016 (in preparation)
- Vite A, Li J, Radice L.G. New functions for alpha-catenins in health and disease: from cancer to heart regeneration. Cell Tissue Res. 2015 Jun;360(3):773-83. doi: 10.1007/s00441-015-2123
- Li J, Gao E, Vite A, Yi R, Gomez L, Goossens S, van Roy F, and Radice G.L. Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity. Circulation Research, 2015 Jan 2;116(1):70-9. doi: 10.1161/CIRCRESAHA.116.304472
- Vite A and Radice G.L. N-Cadherin/Catenin Complex as a Master Regulator of Intercalated Disc Function. Cell Communication and Adhesion. 2014; 21(3), 169-179. doi:10.3109/15419061.2014.908853
- Vite A, Gandjbakhch E, Prost C, Fressart V, Neyroud N, Gary F, Donal E, Varnous S, Fontaine G, Fornes P, Hidden-Lucet F, Komajda M, Charron P and Villard E. Desmosomal cadherin decrease is a signature for Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Plos One, 2013; 8(9):e75082. doi:10.1371/journal.pone.0075082
- Gandjbakhch E, Vite A, Gary F, Fressard V, Simon F, Hidden-Lucet F, Komajda M, Charron P, Villard E. Screening of genes encoding junctional candidates in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Europace 2013; 15(10):1522-5. doi: 10.1093/europace/eut224.
- Gandjbakhch E, Charron P, Fressart V, Lorin de la Grandmaison G, Simon F, Gary F, Vite A, Hainque B, Hidden-Lucet F, Komajda M, Villard E. Plakophilin 2A is the dominant isoform in human heart tissue: consequences for the genetic screening of arrhythmogenic right ventricular cardiomyopathy. Heart 2011; 97:844-9. doi: 10.1136/hrt.2010.205880
Awards
- AHA Postdocoral Fellowship (January 2015)
- Jefferson Graduate School of Biomedical Sciences Postdoctoral Travel Award (June 2014), Thomas Jefferson University, Philadelphia, PA
- Early Discovery Research Poster Award (May 2014 and 2015), Postdoctoral Research Symposium, Thomas Jefferson University, Philadelphia, PA
- Ph.D. Ministerial
Scholarship (June 2009),
University Pierre
et Marie Curie, Paris, France
Languages
Fluent French
-Fluent English
Publications
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Resume Overview
School Attended
- Pierre and Marie Curie University
- Université Paris VI
- Fenelon
Job Titles Held:
- Postdocoral Fellowship
- PhD Student
- Master 2 work experience.
- Master 1 work experience.
Degrees
- Ph.D. : Molecular and cellular mechanisms of Arrhythmogenic Right Ventricular Cardiomyopathy , March 2013
Master of Science : Physiology/Physiopathology , 2009
Bachelor of Science : Biology , June 2007
High School Diploma : June 2004
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