SPECIALTIES: experimental research, in vivo, in vitro, physiology, neurophysiology, assay development.
SUMMARY OF QUALIFICATIONS:
• Extensive experience in design, development, execution and optimization of in vivo and in vitro assays;
• Analytical and technical skills in formulating hypotheses and designing relevant experiments;
• Skills in collecting, managing, analyzing and interpreting experimental data;
• Experience in writing and evaluating research articles, proposals, invention disclosures, reviews, etc.
• Public speaking skills and experience in delivering an effective presentation;
• Strong interpersonal skills and experience in leading people with diverse backgrounds and skills.
Ph.D. in Biological Sciences, Carnegie Mellon University, Pittsburgh, PA. GPA: 4.0.
Integrative Graduate Education and Research Traineeship Program (IGERT, NSF funded) Grant Recipient. Multiple grants from Society for Neuroscience.
M.S. in Physics, Clarkson University, Potsdam, NY. GPA: 4.0. Dean's List. Awards at the Technical Meetings. Thesis research highlighted on front page of American Physical Society News magazine (APS, 2004); overviewed by New Scientist, Advance News, BBC Healthnews, Skin & Aging, , Allure magazine, Cosmetics & Toiletries Magazine, Boa Forma Magazine, Saberviver, Les Nouvelles Estètiques, Veja magazine, and newspapers in USA, UK, Canada, France, Germany, Brazil, India, Portugal, etc.
B.S. in Physics and Biology, National University of Kyiv Mohyla Academy, Kiev, Ukraine.
• Supported drug discovery projects by designing and performing in-vivo and in-vitro experiments:
- Genetically and pharmacologically manipulated drug targets in living cells and animals;
- Collected and analyzed data obtained in drug discovery experiments;
- Reported the experimental results to in-house scientists, managers and reviewers;
- Advised in translating in-vitro models into in-vivo target validation experiments;
- Provided general guidance in understanding of physiology across multiple disease areas.
• Developed and validated experimental platforms to uncover mechanisms of drug action:
- Set up a lab and surgical procedure room to conduct in vivo drug discovery experiments;
- Participated in pharmacodynamics studies to validate drug targets and disease models;
- Developed in-vivo tests to relate molecular mechanisms of drug action to behavioral and
- Developed and maintained a set of regulatory documents (SOPs, IACUC protocols etc);
• Set up synchronized collection of cellular, physiological and behavioral data in rodents:
- Developed and performed procedures for surgical implantation of data collection devices;
- Developed and performed collection, management and analysis of large scale multimodal data
(cellular, EEG, EMG, temperature, locomotion and behavior);
- Developed a set of data visualization and analysis techniques to ensure clear interpretation of the results.
• Trained Scientists and Associates to perform surgical, experimental and data analysis procedures.
• Formulated approved proposals for external academic and commercial collaborative projects.
• Collaborated with external institutions to advance drug discovery projects.
• Presented the results of experiments at internal and external professional meetings and conferences.
• Granted Pioneer Fund Postdoctoral Scholar Award;
• Perfected skills in animal behavior and physiology; designing and programming of lab equipment; surgical techniques; experimental data collection and analysis.
• Worked in interdisciplinary team to develop an optogenetic approach to control genetically modified neurons in primate brain by laser light. Obtained first positive results and preliminary data, a crucial step to secure project funding. Team received Gatsby's Charitable Foundation Research Award (1,000,000/year; 2010-2012);
• Advertised advantages of new technique in a highest ranking journal in the field.
• Implemented novel technique of simultaneous recording of neuronal activity in several areas of brain in non-human primates.
• Proposed and conducted series of experiments that identified basic neuronal mechanism of ordering actions into goal-directed sequences. • With interdisciplinary team, developed novel method of statistical analysis.
• Published series of papers in high impact peer-reviewed journals. • As Teaching Assistant (Biochemistry II and Experimental Biochemistry), lectured on selected topics, led/graded seminars and laboratory classes (200+ students, 2 years).
• As Teaching Assistant (Biochemistry II and Experimental Biochemistry), lectured on selected topics, led/graded seminars and laboratory classes (200+ students, 2 years).
• Developed novel application of atomic force microscopy to study biomechanics of aging human epithelial cells. Published papers in high impact peer-reviewed journals (please see list attached).
• As Teaching Assistant (Physics I and II for Engineering majors), led/graded seminars and laboratory classes; tutored on selected topics (100+ students, 1.5 years).
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA. 05/28/2014. " Novel Approach in Drug Discovery: Multimodal Recordings of Neuronal Activity, Physiological Parameters and Locomotion in Pharmacologically Manipulated Freely Behaving Mammals"
Neurobiology Laboratory Seminar, Salk Institute, 04/30/2014. " Calcium imaging of neuronal activity in relevant circuits in behaving animals"
Computational and Systems Neuroscience Meeting, Department of Bioengineering, UCSD, San Diego, CA. 04/25/2014 , Powell-Focht Bioengineering Hall. "Investigating Mechanisms of Drug Action at the Neuronal Ensemble Level in Behaving Mice: Advantages of In-Vivo Calcium Imaging in Drug Discovery". Computational and Systems Neuroscience Meeting (COSYNE 2014), Salt Lake City, UT. 03/02/2014. " Investigating Mechanisms of Drug Action at the Hippocampal Ensemble Level In Behaving Mice". Society for Neuroscience, Organized Minisymposium “Brain Mechanisms of Sequential Behavior” at Society for Neuroscience Annual Meeting (2007).
Department of Bioengineering, UCSD, San Diego, CA. 04/25/2014 , Powell-Focht Bioengineering Hall. "Investigating Mechanisms of Drug Action at the Neuronal Ensemble Level in Behaving Mice: Advantages of In-Vivo Calcium Imaging in Drug Discovery".
Computational and Systems Neuroscience Meeting (COSYNE 2014), Salt Lake City, UT. 03/02/2014. " Investigating Mechanisms of Drug Action at the Hippocampal Ensemble Level In Behaving Mice".
Society for Neuroscience, Organized Minisymposium “Brain Mechanisms of Sequential Behavior” at Society for Neuroscience Annual Meeting (2007).
•Associate Faculty Member for Cognitive Neuroscience of “Faculty of 1000” (identification and post-publication evaluation of top articles in biology and medicine).
•Member and Minisymposium Organizer, Society for Neuroscience.
•Member of American Physiological Society
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