Global Head, Data Sciences and Advanced Analytics, Pharma IT Resume Example

CoE, in close partnership with the Global RWE leadership team, that is responsible for end to end data management, insightful solutions and advanced analytics for all of Janssen's real world data assets (insurance, claims, EMRs, disease registries and etc.) *Experienced as a member of over 25 project teams in discovery research and pre-clinical development in Oncology, Neuroscience, Immunology and Infectious diseases therapeutic areas. *Led several bio- and chemo-informatics projects, HTS and Structural Biology. *Author of 33 peer reviewed scientific publications and named inventor on 26 patents. *Served as adjunct faculty at Duke University for 6 years. *Presently serving on the Customer Advisory Board for the SAS Corporation. High-profile executive successful at leveraging career experience to enhance organizational productivity and efficiency by effectively directing and supporting operations, services and solutions. High-profile executive successful at leveraging career experience to enhance organizational productivity and efficiency by effectively directing and supporting operations, services and solutions. Distinguished executive accomplished in increasing organizational productivity, reducing staff turnover and discovering cost-saving solutions to operational problems. Cutting edge IT executive with an entrepreneurial spirit, strong business acumen and record of success in delivering solutions to operations, cost management and risk reduction issues. High-performing Executive with 16 years of Healthcare experience. In-depth knowledge of healthcare operations at all levels. Demonstrated proficiency in staffing, training and development, budgeting and program management. Innovative Product Executive with proven ability to create highly profitable programs through marketing, training, and partner relationships. Experienced executive specializing in corporate development and strategic planning.

Swinney, D.; Beavis, P.; Chuang, K.; Zheng, Y.; Lee, I.; Gee, P.; Deval, J,; Rotstein, D.; Dioszegi, M.; Zhang, J.; Sankuratri, S.; Kondru, Rama; CCR5 antagonist binding dynamics: Dissecting Unique Receptor Conformational Changes Associated with the Binding of CCR5 Antagonists Using Mutant Receptors. Submitted, PNAS, 2012. *Kondru, Rama; Zhang, J.; Ji, C.; Mirzadegan, T.; Rotstein, D.; Sankuratri, S.; Dioszegi, M.; Molecular interactions of CCR5 with major classes of small-molecule anti HIV CCR5 antagonists. Molecular Pharmacology, 2008, 73:789-800. *Parks, J.; Kondru, Rama; Hua, H.; Beratan, D.; Yang, W.; Nature of ligand binding in hepatitis C virus NS5B polymerase: Important roles of the internal energy and van der Waals interactions from QM/MM calculations. J. Phys. Chem.B. 2008, 112 (10), 3168 -3176. *Dasse, O. A.;Evans, J. L.;Zhai, H.-X.;Zou, D.;Kintigh, J. T.;Chan, F.;Hamilton, K.;Hill, E.;Eckman, J. B.;Higgins, P. J.;Volosov, A.;Collart, P.;Nicolas, J.-M.;Kondru, Rama;Schwartz, C.E.; Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization.; Letters in Drug Design and Discovery, 2007, 4, 263-271. *Zhang, J.; Rao, E.; Dioszegi, M.; Kondru, Rama; DeRosier, A.; Chan, E.; Schwoerer, S.; Cammack, N.; Brandt, M.; Sankuratri, S.; Ji, C.; The second extracellular loop of CCR5 contains the dominant epitopes for highly potent anti-human immunodeficiency virus monoclonal antibodies. Antimicrobial Agents and Chemotherapy. 2007, 51(4), 1386-1397. *Beratan, D. N.; Kondru, Rama; and Wipf, P.; Optical activity: From structure-function to structure prediction. Physical Chemistry of Chirality, Conference Proceedings. 219th ACS Symposium Series, American Chemical Society Publication, Book Chapter. 2001. *Specht , K. M.; Nam, J.; Ho, D.; Berova , N.; Kondru , Rama; Beratan , D. N.; Wipf, P.; Pascal, R. Jr.; and Kahne, D.; Exciton Chirality Circular Dichroism: Inadequacies in Determination of Absolute Configuration in Flexible Molecules. J. Am. Chem. Soc. 2001, 123, 8961-8966. *Perry, T. L.; Dickerson, A.; Khan, A. A.; Kondru, Rama; Beratan, D. N.; Wipf, P.; Kelly, M.; Hamann, M. T.; New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii. Tetrahedron 2001, 57, 1483-1487. *Kondru, Rama; Singh, A. K. Techsighting/software: Turning structures into gold. Science 2000, 288(5473), 1981-1982. *Kondru, Rama; Beratan, D.; Friestad, G.; Smith, A.; Wipf, P.; Chiral action at a distance: Remote substituent effects on the optical activity of Calyculin A and B. Organic Letters 2000, 2, 1509-1512. *Ribe, S.; Kondru, Rama; Beratan, D.; and Wipf, P.; Optical rotation computation, Total Synthesis and stereochemistry assignment of the marine natural product pitiamide A. J. Am. Chem. Soc. 2000, 122, 4608-4617. *Kondru, Rama; Chirstine, C.; Curran, D.; Beratan, D.; Wipf, P.; Determination of the absolute stereochemistry of 1,3,5,7-tetramethyl-1,3dihydroindol-2-one by optical rotation computation. Tetrahedron Asymmetry 1999, 10, 4143-4150. *Kondru, Rama; Wipf, P.; Beratan, D.; Structural and conformational dependence of optical rotational angles. J. Chem. Phys. A. 1999, 103, 6603. *Kondru, Rama; Wipf, P.; Beratan, D.; Atomic contributions to the optical rotation angle as a quantitative probe of molecular chirality. Science 1998, 282, 2247. *Kondru, Rama; Wipf, P.; Beratan, D.; Theory-assisted determination of absolute stereochemistry for complex natural products via computation of molar rotation angles. J. Am. Chem. Soc. 1998, 120, 2204. *Kondru, Rama; Lim, S.; Wipf, P.; Beratan, D.; Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: a reinvestigation of van't Hoff's principle. Chirality 9, 469, 1997. *Mathur. P.; Hossain, M.; Datta, S.; Kondru, Rama; Bhadbhade, M.; Functionalization of a diacetylene on the mixed-chalcogenide compound Fe2(CO)6(* -STe). Structural characterization of (CO)6Fe2{* -SC(C* CCH3)=C(H)Te}. Organometallics 13, 2532, 1994. *Datta, S.; Kondru, Rama; Mathur, P. Molecular-orbital calculations on Fe4(CO)10(* -CO)( * -4-Se)2 and Fe3Ru(CO)10(* -CO)( * -4-Se)2. J. Organometallic Chem. 470, 169, 1994.

Georgette Castanedo, Bryan Chan, David Goldstein, Rama Kondru, Matthew Lucas, Wylie Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary K Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; US Patent 20120178736. *Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang: Pyrrolopyrazine kinase inhibitors. March 8, 2011: US07902197 * Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. April 26, 2011: US07932254 *Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith,Michael Soth, Hanbiao Yang, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. May 10, 2011: US07939531 *Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel: Btk protein kinase inhibitors. May 17, 2011: US07943618 *Dewdney, Nolan James; Kondru, Rama; Loe, Bradley E.; Lou, Yan; McIntosh, Joel; Owens, Timothy D.; Soth, Michael; Preparation of novel substituted pyridin-2-ones and pyridazin-3-ones; Patent WO 2009156284. *Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth; Inhibitors of Bruton's Tyrosine Kinase; US Patent 20120129845. *Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth, Calvin Wesley Yee; Pyrrolopyrazine derivatives as syk and jak inhibitors, Patent WO2011144584. *Robert Than Hendricks, Johannes Hermann, Saul Jaime-Figueroa, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288,067. *Robert Than Hendricks, Johannes Hermann, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee,; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288097. *Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth; Pyrrolopyrazine kinase inhibitors; WO Patent WO2011117145. *Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel; Btk protein kinase inhibitors; US Patent 7,943,618; *Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors;; US Patent 7,939,531. *Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; DJ DuBois, US Patent 7,932,254. *Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of bruton's tyrosine kinase; US Patent 7,906,509. *Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth; Inhibitors of bruton's tyrosine kinase; US Patent 7,902,194. *Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang; Pyrrolopyrazine kinase inhibitors; US Patent 7,902,197. *Georgette Castanedo, Bryan Chan, David Michael Goldstein, Rama Kondru, Matthew C Lucas, Wylie Solang Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary Kevin Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; WO Patent WO2010138589. *Nolan James Dewdney, Ronald Charles Hawley, Rama Kondru, Yingjie Lai, Yan Lou; Inhibitors of bruton's tyrosine kinase; WO Patent WO2010122038. *Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loc, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of Bruton's tyrosine kinase; US Patent 7,683,064. *Rama Kondru, Yan Lou, Eric Brian Sjogren, Michael Soth; Novel phenylimidazopyrazines; WO Patent WO2010006970. *Joe Timothy Bamberg, Mark Bartlett, Du Bois, Daisy Joe, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; WO Patent WO2009106442. *Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Novel pyridinones and pyridazinones; WO Patent WO2009098144. *Nolan James Dewdney, Tobias Gabriel, Rama Kondru, Yan Lou, Michael Soth; Novel kinase inhibitors; WO Patent WO2009053269. *Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; Novel antagonist for CCR2. U.S. Patent 6,727,275. *Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; CCR2 : Pyrrolidinone derivatives. WO2003030897. PUBLICATIONS *A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds. J A DiMasi, J C Hermann, K Twyman, Rama Kondru, S Stergiopoulos, K A Getz, W Rackoff. Clinical Pharmacology and Therapeutics 2015, 98 (5): 506-13. *Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis. Yan Lou, Xiaochun Han, Andreas Kuglstatter, Rama Kondru, Zachary K Sweeney, Michael Soth, Joel McIntosh, Renee Litman, Judy Suh, Buelent Kocer, Dana Davis, Jaehyeon Park, Sandra Frauchiger,Nolan Dewdney, Hasim Zecic, Joshua P Taygerly, Keshab Sarma, Junbae Hong, Ronald J Hill, Tobias Gabriel, David M Goldstein, Timothy D Owens. J Med Chem 2015 Jan 16;58(1):512- *A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands. David C Swinney, Paul Beavis, Kai-Ting Chuang, Yue Zheng, Ina Lee, Peter Gee, Jerome Deval, David M Rotstein,Marianna Dioszegi, Palani Ravendran, Jun Zhang, Surya Sankuratri, Rama Kondru, Georges Vauquelin. Br J Pharmacol 2014 Jul;171(14):3364-75. *Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold. Yan Lou, Zachary K Sweeney, Andreas Kuglstatter, Dana Davis, David M Goldstein, Xiaochun Han,Junbae Hong, Buelent Kocer, Rama Kondru, Renee Litman, Joel McIntosh, Keshab Sarma, Judy Suh,Joshua Taygerly, Timothy D Owens. Bioorg Med Chem Lett 2015 Jan 20;25(2):367-71.