Georgette Castanedo, Bryan Chan, David Goldstein, Rama Kondru, Matthew Lucas, Wylie Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary K Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; US Patent 20120178736.
*Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang: Pyrrolopyrazine kinase inhibitors. March 8, 2011: US07902197
* Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. April 26, 2011: US07932254
*Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith,Michael Soth, Hanbiao Yang, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. May 10, 2011: US07939531
*Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel: Btk protein kinase inhibitors. May 17, 2011: US07943618
*Dewdney, Nolan James; Kondru, Rama; Loe, Bradley E.; Lou, Yan; McIntosh, Joel; Owens, Timothy D.; Soth, Michael; Preparation of novel substituted pyridin-2-ones and pyridazin-3-ones; Patent WO 2009156284.
*Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth; Inhibitors of Bruton's Tyrosine Kinase; US Patent 20120129845.
*Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth, Calvin Wesley Yee; Pyrrolopyrazine derivatives as syk and jak inhibitors, Patent WO2011144584.
*Robert Than Hendricks, Johannes Hermann, Saul Jaime-Figueroa, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288,067.
*Robert Than Hendricks, Johannes Hermann, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee,; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288097.
*Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth; Pyrrolopyrazine kinase inhibitors; WO Patent WO2011117145.
*Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel; Btk protein kinase inhibitors; US Patent 7,943,618;
*Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors;; US Patent 7,939,531.
*Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; DJ DuBois, US Patent 7,932,254.
*Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of bruton's tyrosine kinase; US Patent 7,906,509.
*Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth; Inhibitors of bruton's tyrosine kinase; US Patent 7,902,194.
*Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang; Pyrrolopyrazine kinase inhibitors; US Patent 7,902,197.
*Georgette Castanedo, Bryan Chan, David Michael Goldstein, Rama Kondru, Matthew C Lucas, Wylie Solang Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary Kevin Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; WO Patent WO2010138589.
*Nolan James Dewdney, Ronald Charles Hawley, Rama Kondru, Yingjie Lai, Yan Lou; Inhibitors of bruton's tyrosine kinase; WO Patent WO2010122038.
*Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loc, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of Bruton's tyrosine kinase; US Patent 7,683,064.
*Rama Kondru, Yan Lou, Eric Brian Sjogren, Michael Soth; Novel phenylimidazopyrazines; WO Patent WO2010006970.
*Joe Timothy Bamberg, Mark Bartlett, Du Bois, Daisy Joe, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; WO Patent WO2009106442.
*Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Novel pyridinones and pyridazinones; WO Patent WO2009098144.
*Nolan James Dewdney, Tobias Gabriel, Rama Kondru, Yan Lou, Michael Soth; Novel kinase inhibitors; WO Patent WO2009053269.
*Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; Novel antagonist for CCR2. U.S. Patent 6,727,275.
*Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; CCR2 : Pyrrolidinone derivatives. WO2003030897.
PUBLICATIONS
*A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds. J A DiMasi, J C Hermann, K Twyman, Rama Kondru, S Stergiopoulos, K A Getz, W Rackoff. Clinical Pharmacology and Therapeutics 2015, 98 (5): 506-13.
*Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis. Yan Lou, Xiaochun Han, Andreas Kuglstatter, Rama Kondru, Zachary K Sweeney, Michael Soth, Joel McIntosh, Renee Litman, Judy Suh, Buelent Kocer, Dana Davis, Jaehyeon Park, Sandra Frauchiger,Nolan Dewdney, Hasim Zecic, Joshua P Taygerly, Keshab Sarma, Junbae Hong, Ronald J Hill, Tobias Gabriel, David M Goldstein, Timothy D Owens. J Med Chem 2015 Jan 16;58(1):512-
*A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands. David C Swinney, Paul Beavis, Kai-Ting Chuang, Yue Zheng, Ina Lee, Peter Gee, Jerome Deval, David M Rotstein,Marianna Dioszegi, Palani Ravendran, Jun Zhang, Surya Sankuratri, Rama Kondru, Georges Vauquelin. Br J Pharmacol 2014 Jul;171(14):3364-75.
*Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold. Yan Lou, Zachary K Sweeney, Andreas Kuglstatter, Dana Davis, David M Goldstein, Xiaochun Han,Junbae Hong, Buelent Kocer, Rama Kondru, Renee Litman, Joel McIntosh, Keshab Sarma, Judy Suh,Joshua Taygerly, Timothy D Owens. Bioorg Med Chem Lett 2015 Jan 20;25(2):367-71.