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Global Head, Data Sciences and Advanced Analytics, Pharma IT Resume Example

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GLOBAL HEAD, DATA SCIENCES AND ADVANCED ANALYTICS, PHARMA IT
Professional Summary
CoE, in close partnership with the Global RWE leadership team, that is responsible for end to end data management, insightful solutions and advanced analytics for all of Janssen's real world data assets (insurance, claims, EMRs, disease registries and etc.) *Experienced as a member of over 25 project teams in discovery research and pre-clinical development in Oncology, Neuroscience, Immunology and Infectious diseases therapeutic areas. *Led several bio- and chemo-informatics projects, HTS and Structural Biology. *Author of 33 peer reviewed scientific publications and named inventor on 26 patents. *Served as adjunct faculty at Duke University for 6 years. *Presently serving on the Customer Advisory Board for the SAS Corporation. High-profile executive successful at leveraging career experience to enhance organizational productivity and efficiency by effectively directing and supporting operations, services and solutions. High-profile executive successful at leveraging career experience to enhance organizational productivity and efficiency by effectively directing and supporting operations, services and solutions. Distinguished executive accomplished in increasing organizational productivity, reducing staff turnover and discovering cost-saving solutions to operational problems. Cutting edge IT executive with an entrepreneurial spirit, strong business acumen and record of success in delivering solutions to operations, cost management and risk reduction issues. High-performing Executive with 16 years of Healthcare experience. In-depth knowledge of healthcare operations at all levels. Demonstrated proficiency in staffing, training and development, budgeting and program management. Innovative Product Executive with proven ability to create highly profitable programs through marketing, training, and partner relationships. Experienced executive specializing in corporate development and strategic planning.
Skills
  • Executive & interdisciplinary Business Partner engagement; Financial Planning & Analysis; Licensing & Contract Management; Vendor & Alliance Management; Disciplined Execution & Delivery; Organizational Change Management; Recruiting & Talent Development.
  • IT & ANALYTICS: Technology Transformation; Portfolio & Project Management; Cloud Computing; Operational Excellence; Applications Development; Business Process Mapping & Improvement; HIPAA Data Compliance; Business Intelligence; Semantic Data Integration; Machine Learning & Artificial Intelligence; Natural Language Processing, Big Data Informatics; Mining & Visualization; Data Management; Technology & Vendor management; Agile Delivery. Rapid Mining of Protein-Ligand Interactions in Large Crystal Structure Databases. Weisel, Martin; Bitter, Hans-Marcus; Diederich, Francois; So, W. Venus; Kondru, Rama; Journal of Chemical Information and Modeling, 2012, 52(6), 1450-1461.
  • Discovery of Highly Selective and Orally Active Lysophosphatidic Acid Receptor-1 Antagonists with Potent Activity on Human Lung Fibroblasts; Qian, Yimin; Hamilton, Matthew; Sidduri, Achyutharao; Gabriel, Stephen; Ren, Yonglin; Peng, Ruoqi; Kondru, Rama; Narayanan, Arjun; Truitt, Terry; Hamid, Rachid; et al. Journal of Medicinal Chemistry (2012), 55(17), 7920-7939.
  • Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta Full Text By Murray, Jeremy M.; Sweeney, Zachary K.; Chan, Bryan K.; Balazs, Mercedesz; Bradley, Erin; Castanedo, Georgette; Chabot, Christine; Chantry, David; Flagella, Michael; Goldstein, David M.; Kondru, Rama; et al. Journal of Medicinal Chemistry (2012), 55(17), 7686-7695.
  • Bruton's Tyrosine Kinase Inhibitors: Approaches to Potent and Selective Inhibition, Preclinical and Clinical Evaluation for Inflammatory Diseases and B Cell Malignancies. Lou, Yan; Owens, Timothy D.; Kuglstatter, Andreas; Kondru, Rama; Goldstein, David M.; Journal of Medicinal Chemistry, 2012, 55(10), 4539-4550.
  • Potent and selective inhibitors of PI3K
  • Obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Sutherlin, Daniel P.; Baker, Stewart; Kondru, Rama; Sweeney, Zachary K. et. al.; Bioorganic & Medicinal Chemistry Letters, 2012, 22(13), 4296-4302.
  • Discovery of Novel PI3-Kinase
  • Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition Full Text By Safina, Brian S.; Baker, Stewart; Baumgardner, Matt; Blaney, Paul M.; Chan, Bryan K.; Chen, Yung-Hsiang; Cartwright, Matthew W.; Kondru, Rama; Castanedo, Georgette; Chabot, Christine; Cheguillaume, Arnaud J.; et al. Journal of Medicinal Chemistry, 2012, 55(12), 5887-5900.
  • Tanrikulu, Yusuf; Kondru, Rama; Schneider, Gisbert; So, W. Venus; Bitter, Hans-Marcus. Missing Value Estimation for Compound-Target Activity Data. Molecular Informatics, 2010, 29(10), 678-684.
  • Olaharski, Andrew J.; Bitter, Hans; Gonzaludo, Nina; Kondru, Rama; Goldstein, David M.; Zabka, Tanja S.; Lin, Henry; Singer, Thomas; Kolaja, Kyle. Modeling Bone Marrow Toxicity Using Kinase Structural Motifs and the Inhibition Profiles of Small Molecular Kinase Inhibitors. Toxicological Sciences, 2010, 118(1), 266-275.
  • Wanner, Jutta; Chen, Lijing; Lemoine, Remy C.; Kondru, Rama; Jekle, Andreas; Heilek, Gabrielle; de Rosier, Andre; Ji, Changhua; Berry, Pamela W.; Rotstein, David M. Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series. Bioorganic & Medicinal Chemistry Letters, 2010, 20(22), 6802-6807.
  • Villasenor, Armando G.; Kondru, Rama; Ho, Hoangdung; Wang, Sandra; Papp, Eva; Shaw, David; Barnett, Jim W.; Browner, Michelle F.; Kuglstatter, Andreas. Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes. Chemical Biology & Drug Design, 2009, 73(4), 466-470.
  • Martin, Renee S.; Henningsen, Robert A.; Suen, Alexander; Apparsundaram, Subbu; Leung, Becky; Jia, Zhongjiang; Kondru, Rama; Milla, Marcos E. Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors. Journal of Pharmacology and Experimental Therapeutics, 2008, 327(3), 991-1000.
  • Agile methodologies
  • Business process improvement
  • Requirements gathering
  • Project cost planning
  • Collaboration tools
  • Effective multi-tasker
  • Platform scalability forecasting
  • Strategic planning
  • Data analysis
  • Product launches
  • Effective multi-tasker
  • MS Project
  • IT security best practices
  • Strategic objective execution
  • Full lifecycle development
  • Scalable systems
  • Managing multiple projects simultaneously
  • Team player
  • Modular design
  • Large computer networks
Publications
Swinney, D.; Beavis, P.; Chuang, K.; Zheng, Y.; Lee, I.; Gee, P.; Deval, J,; Rotstein, D.; Dioszegi, M.; Zhang, J.; Sankuratri, S.; Kondru, Rama; CCR5 antagonist binding dynamics: Dissecting Unique Receptor Conformational Changes Associated with the Binding of CCR5 Antagonists Using Mutant Receptors. Submitted, PNAS, 2012. *Kondru, Rama; Zhang, J.; Ji, C.; Mirzadegan, T.; Rotstein, D.; Sankuratri, S.; Dioszegi, M.; Molecular interactions of CCR5 with major classes of small-molecule anti HIV CCR5 antagonists. Molecular Pharmacology, 2008, 73:789-800. *Parks, J.; Kondru, Rama; Hua, H.; Beratan, D.; Yang, W.; Nature of ligand bindingin hepatitis C virus NS5B polymerase: Important roles of the internal energy and van der Waals interactions from QM/MM calculations. J. Phys. Chem.B. 2008, 112 (10), 3168 -3176. *Dasse, O. A.;Evans, J. L.;Zhai, H.-X.;Zou, D.;Kintigh, J. T.;Chan, F.;Hamilton, K.;Hill, E.;Eckman, J. B.;Higgins, P. J.;Volosov, A.;Collart, P.;Nicolas, J.-M.;Kondru, Rama;Schwartz, C.E.; Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization.; Letters in Drug Design and Discovery, 2007, 4, 263-271. *Zhang, J.; Rao, E.; Dioszegi, M.; Kondru, Rama; DeRosier, A.; Chan, E.; Schwoerer, S.; Cammack, N.; Brandt, M.; Sankuratri, S.; Ji, C.; The second extracellular loop of CCR5 contains the dominant epitopes for highly potent anti-human immunodeficiency virus monoclonal antibodies. Antimicrobial Agents and Chemotherapy. 2007, 51(4), 1386-1397. *Beratan, D. N.; Kondru, Rama; and Wipf, P.; Optical activity: From structure-function to structure prediction. Physical Chemistry of Chirality, Conference Proceedings. 219th ACS Symposium Series, American Chemical Society Publication, Book Chapter. 2001. *Specht , K. M.; Nam, J.; Ho, D.; Berova , N.; Kondru , Rama; Beratan , D. N.; Wipf, P.; Pascal, R. Jr.; and Kahne, D.; Exciton Chirality Circular Dichroism: Inadequacies in Determination of Absolute Configuration in Flexible Molecules. J. Am. Chem. Soc. 2001, 123, 8961-8966. *Perry, T. L.; Dickerson, A.; Khan, A. A.; Kondru, Rama; Beratan, D. N.; Wipf, P.; Kelly, M.; Hamann, M. T.; New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii. Tetrahedron 2001, 57, 1483-1487. *Kondru, Rama; Singh, A. K. Techsighting/software: Turning structures into gold. Science 2000, 288(5473), 1981-1982. *Kondru, Rama; Beratan, D.; Friestad, G.; Smith, A.; Wipf, P.; Chiral action at a distance: Remote substituent effects on the optical activity of Calyculin A and B. Organic Letters 2000, 2, 1509-1512. *Ribe, S.; Kondru, Rama; Beratan, D.; and Wipf, P.; Optical rotation computation, Total Synthesis and stereochemistry assignment of the marine natural product pitiamide A. J. Am. Chem. Soc. 2000, 122, 4608-4617. *Kondru, Rama; Chirstine, C.; Curran, D.; Beratan, D.; Wipf, P.; Determination of the absolute stereochemistry of 1,3,5,7-tetramethyl-1,3dihydroindol-2-one by optical rotation computation. Tetrahedron Asymmetry 1999, 10, 4143-4150. *Kondru, Rama; Wipf, P.; Beratan, D.; Structural and conformational dependence of optical rotational angles. J. Chem. Phys. A. 1999, 103, 6603. *Kondru, Rama; Wipf, P.; Beratan, D.; Atomic contributions to the optical rotation angle as a quantitative probe of molecular chirality. Science 1998, 282, 2247. *Kondru, Rama; Wipf, P.; Beratan, D.; Theory-assisted determination of absolute stereochemistry for complex natural products via computation of molar rotation angles. J. Am. Chem. Soc. 1998, 120, 2204. *Kondru, Rama; Lim, S.; Wipf, P.; Beratan, D.; Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: a reinvestigation of van't Hoff's principle. Chirality 9, 469, 1997. *Mathur. P.; Hossain, M.; Datta, S.; Kondru, Rama; Bhadbhade, M.; Functionalization of a diacetylene on the mixed-chalcogenide compound Fe2(CO)6(* -STe). Structural characterization of (CO)6Fe2{* -SC(C* CCH3)=C(H)Te}. Organometallics 13, 2532, 1994. *Datta, S.; Kondru, Rama; Mathur, P. Molecular-orbital calculations on Fe4(CO)10(* -CO)( * -4-Se)2 and Fe3Ru(CO)10(* -CO)( * -4-Se)2. J. Organometallic Chem. 470, 169, 1994.
Work History
Global Head, Data Sciences and Advanced Analytics, Pharma ITPearson01/2013 - Current
  • Data Sciences, Janssen Pharma IT.
  • Shaping the long-term vision and strategy of the data sciences organization.
  • Leading the delivery of scientific analyses, solutions and systems in support of Janssen business groups and innovation centers (Katalyst, AAA, Atlas, ANDI and etc.).
  • Leading, implementing and creating novel IT solutions to influence how we as an organization make decisions using disruptive technologies and leveraging data.
  • Creating a strategic foundation of RWE data assets with end to end data management, advanced analytics capabilities and services, leveraging scalable big data and cloud technologies.
  • Set strategy and contributed significantly in global initiatives and multidisciplinary work groups serving on the Pharma IT Leadership Team, global RWE leadership team, and Commercial Medical Affairs and Scientific Affairs leadership council.
  • Co-leader of several enterprise IT initiatives to harmonize and innovate IT solutions, including Co-champion of worldwide "DnA - Data and Analytics" workgroup and co-leader of J&J's Health Tech innovation streams in Machine Learning and Big Data.
  • Translated business goals, feature concepts and customer needs into prioritized product requirements and use cases.
  • Translated business goals, feature concepts and customer needs into prioritized product requirements and use cases.
  • Developed and evolved the consumer-facing, multi-channel roadmap for desktop, mobile and mobile web applications.
  • Collaborated with the sales, marketing and support teams to launch products on time and within budget.
  • Created innovative and intuitive product features such as [Example].
  • Established criteria for each milestone within the product roadmap as a means to measure developmental progress.
  • Partnered with the marketing team to translate product features into customer value propositions to be used in consumer messaging.
  • Partnered with the marketing team to translate product features into customer value propositions to be used in consumer messaging.
  • Led communication with stakeholders regarding product goals and progress made.
  • Coached and mentored [Number] new staff members, including conducting performance reviews.



Associate Director and HeadHealth Research, Inc. - Warren , NY01/2009 - 01/2012
  • Computational Chemistry and Data Mining (CCDM) Group.
  • Managed a group of Ph.D.
  • Scientists and post-doctoral scientists.
  • Led the Nutley cross-disciplinary Discovery Informatics team for over two years creating strategic direction, prioritization, and execution of informatics solutions for analyses, interpretation and visualization of large datasets, knowledge generation and dissemination throughout Pharma Research and Early Development (pRED).
  • Provided scientific leadership for the redesign of modeling and HTS hit triage process.
  • Enabled interactive and data driven real time structure-based design processes supporting discovery project activities across Roche and Genentech partnerships.
  • Translated business goals, feature concepts and customer needs into prioritized product requirements and use cases.
  • Translated technical specifications into detailed product requirements.


Project leader Global Chemical Biology Initiative
  • Member of the joint steering committee on Chemical Biology, responsible for project prioritization, governance and budget, with a remit to deliver novel targets into the Roche portfolio.
  • As the project leader on repurposing, initiated collaborations with multiple institutions including a multi-million dollar collaboration with the Broad Institute.
  • Responsible for leveraging large data sets obtained through external collaborations to create disease correlation and to deliver value to all therapy areas.
Principal Research ScientistBristol Myers Squibb - New Rochelle , TX01/2008 - 01/2009
Research Scientist-II
  • Member of the global kinase core group responsible for developing chemo-informatics strategies for kinase targets resulting in Kinase Data Mart, and other informatics tools.
  • Provided scientific leadership to defining a global strategy on chemo-informatics and off-target (lateral) data mining at Roche.
  • Led the development and integration of Roche Universal Force-Field in MOE (Molecular Operating Environment) in collaboration with CCG (Chemical Computing Group Inc.).
  • Provided data mining and scientific computing support with analyses and informatics solutions for over 15 drug discovery projects.
Principal ScientistPlanet Pharma - Longview , IL01/2004 - 01/2004
Senior Scientist-III
Senior Scientist-II
  • Directed a team of scientists and in-silico research to identify and validate novel targets.
  • Managed the software and hardware tools for the computational chemistry group.
  • Participated in a global cross-site working group to reshape UCB's screening library.
Senior Research ScientistAbbvie, Inc - Mettawa , NV01/2000
  • Conducted research and data analysis for simulation of polymer networks.
Adjunct ProfessorMerck & Co., Inc. - NJ01/2002 - 01/2009
  • Initiated multiple collaborative projects between Duke and Roche.
Marquette University - Reno , WI03/2012 - 04/2012
  • Kondru, Rama; Lackey, K.; Chemical Biology: Creating New Opportunities From Roche Advanced, But Terminated Compounds; The 2nd Annual Drug Repositioning & Indications Discovery Conference, San Francisco Bay Area, CA USA, October 23-24, 2012.
  • Kondru, Rama; Medicinal chemists as modelers - tips, tricks and way forward.
  • 243rd ACS National Meeting & Exposition Kondru, Rama; Using Mutational Data To Drive Drug Design: Does It Really Work.
  • CCG User Group Meeting, Montreal, Canada, June, 2011.
  • Tanrikulu, Yusuf; Weisel, Martin; Kondru, Rama; Bitter, Hans M.
  • Interaction Maps: Understanding compound pathway space.
  • Abstracts of Papers, 239th ACS National Meeting.
Rahway , MI03/2017 - 01/2010
  • Kondru, Rama; Kinase Data Mart: Browsing and Shopping for Kinase Data.
  • Bridging Pharma IT Meeting in Providence, RI, October 28-30, 2008.
Education
Post-doctoral fellow: University of Pittsburgh Medical Center - 2000

Ph.D: Biophysics and Quantum ChemistryUniversity of Pittsburgh Peter Wipf University of Pittsburgh Prof. David Beratan Duke University - 1999
Biophysics and Quantum Chemistry
B.S and M.S: Indian Institute of Technology (I. I. T - May, 1994
Article featured on cover of Journal of Chemical Information and Modeling, 2012, 52(6). *Article featured on cover of Toxicological Sciences, , volume 118. *Experiment of the Quarter Award, UCB Research Inc.,
Interests
Georgette Castanedo, Bryan Chan, David Goldstein, Rama Kondru, Matthew Lucas, Wylie Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary K Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; US Patent 20120178736. *Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang: Pyrrolopyrazine kinase inhibitors. March 8, 2011: US07902197 * Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. April 26, 2011: US07932254 *Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith,Michael Soth, Hanbiao Yang, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. May 10, 2011: US07939531 *Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel: Btk protein kinase inhibitors. May 17, 2011: US07943618 *Dewdney, Nolan James; Kondru, Rama; Loe, Bradley E.; Lou, Yan; McIntosh, Joel; Owens, Timothy D.; Soth, Michael; Preparation of novel substituted pyridin-2-ones and pyridazin-3-ones; Patent WO 2009156284. *Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth; Inhibitors of Bruton's Tyrosine Kinase; US Patent 20120129845. *Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth, Calvin Wesley Yee; Pyrrolopyrazine derivatives as syk and jak inhibitors, Patent WO2011144584. *Robert Than Hendricks, Johannes Hermann, Saul Jaime-Figueroa, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288,067. *Robert Than Hendricks, Johannes Hermann, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee,; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288097. *Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth; Pyrrolopyrazine kinase inhibitors; WO Patent WO2011117145. *Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel; Btk protein kinase inhibitors; US Patent 7,943,618; *Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors;; US Patent 7,939,531. *Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; DJ DuBois, US Patent 7,932,254. *Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of bruton's tyrosine kinase; US Patent 7,906,509. *Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth; Inhibitors of bruton's tyrosine kinase; US Patent 7,902,194. *Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang; Pyrrolopyrazine kinase inhibitors; US Patent 7,902,197. *Georgette Castanedo, Bryan Chan, David Michael Goldstein, Rama Kondru, Matthew C Lucas, Wylie Solang Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary Kevin Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; WO Patent WO2010138589. *Nolan James Dewdney, Ronald Charles Hawley, Rama Kondru, Yingjie Lai, Yan Lou; Inhibitors of bruton's tyrosine kinase; WO Patent WO2010122038. *Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loc, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of Bruton's tyrosine kinase; US Patent 7,683,064. *Rama Kondru, Yan Lou, Eric Brian Sjogren, Michael Soth; Novel phenylimidazopyrazines; WO Patent WO2010006970. *Joe Timothy Bamberg, Mark Bartlett, Du Bois, Daisy Joe, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; WO Patent WO2009106442. *Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Novel pyridinones and pyridazinones; WO Patent WO2009098144. *Nolan James Dewdney, Tobias Gabriel, Rama Kondru, Yan Lou, Michael Soth; Novel kinase inhibitors; WO Patent WO2009053269. *Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; Novel antagonist for CCR2. U.S. Patent 6,727,275. *Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; CCR2 : Pyrrolidinone derivatives. WO2003030897. PUBLICATIONS *A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds. J A DiMasi, J C Hermann, K Twyman, Rama Kondru, S Stergiopoulos, K A Getz, W Rackoff. Clinical Pharmacology and Therapeutics 2015, 98 (5): 506-13. *Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis. Yan Lou, Xiaochun Han, Andreas Kuglstatter, Rama Kondru, Zachary K Sweeney, Michael Soth, Joel McIntosh, Renee Litman, Judy Suh, Buelent Kocer, Dana Davis, Jaehyeon Park, Sandra Frauchiger,Nolan Dewdney, Hasim Zecic, Joshua P Taygerly, Keshab Sarma, Junbae Hong, Ronald J Hill, Tobias Gabriel, David M Goldstein, Timothy D Owens. J Med Chem 2015 Jan 16;58(1):512- *A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands. David C Swinney, Paul Beavis, Kai-Ting Chuang, Yue Zheng, Ina Lee, Peter Gee, Jerome Deval, David M Rotstein,Marianna Dioszegi, Palani Ravendran, Jun Zhang, Surya Sankuratri, Rama Kondru, Georges Vauquelin. Br J Pharmacol 2014 Jul;171(14):3364-75. *Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold. Yan Lou, Zachary K Sweeney, Andreas Kuglstatter, Dana Davis, David M Goldstein, Xiaochun Han,Junbae Hong, Buelent Kocer, Rama Kondru, Renee Litman, Joel McIntosh, Keshab Sarma, Judy Suh,Joshua Taygerly, Timothy D Owens. Bioorg Med Chem Lett 2015 Jan 20;25(2):367-71.
Additional Information
  • AWARDS AND SCIENTIFIC RECOGNITION *Janssen Leadership Award, Oncology Therapeutic Area, 2015. *Janssen Leadership Award for Innovation, 2014.
  • PATENTS *Georgette Castanedo, Bryan Chan, David Goldstein, Rama Kondru, Matthew Lucas, Wylie Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary K Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; US Patent 20120178736. *Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang: Pyrrolopyrazine kinase inhibitors. March 8, 2011: US07902197 * Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. April 26, 2011: US07932254 *Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith,Michael Soth, Hanbiao Yang, Calvin Wesley Yee: Pyrrolopyrazine kinase inhibitors. May 10, 2011: US07939531 *Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel: Btk protein kinase inhibitors. May 17, 2011: US07943618 *Dewdney, Nolan James; Kondru, Rama; Loe, Bradley E.; Lou, Yan; McIntosh, Joel; Owens, Timothy D.; Soth, Michael; Preparation of novel substituted pyridin-2-ones and pyridazin-3-ones; Patent WO 2009156284. *Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth; Inhibitors of Bruton's Tyrosine Kinase; US Patent 20120129845. *Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth, Calvin Wesley Yee; Pyrrolopyrazine derivatives as syk and jak inhibitors, Patent WO2011144584. *Robert Than Hendricks, Johannes Hermann, Saul Jaime-Figueroa, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288,067. *Robert Than Hendricks, Johannes Hermann, Rama Kondru, Yan Lou, Stephen Lynch, Timothy D Owens, Michael Soth, Calvin Yee,; Pyrrolopyrazine Kinase Inhibitors; US Patent 20110288097. *Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Stephen M Lynch, Timothy D Owens, Michael Soth; Pyrrolopyrazine kinase inhibitors; WO Patent WO2011117145. *Nolan James Dewdney, Rama Kondru, Yan Lou, Michael Soth, Tobias Gabriel; Btk protein kinase inhibitors; US Patent 7,943,618; *Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors;; US Patent 7,939,531. *Daisy Joe DuBois, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Yan Lou, Timothy D Owens, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; DJ DuBois, US Patent 7,932,254. *Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of bruton's tyrosine kinase; US Patent 7,906,509. *Nolan James Dewdney, Rama Kondru, Bradley E Loe, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth; Inhibitors of bruton's tyrosine kinase; US Patent 7,902,194. *Todd Richard Elworthy, Robert Than Hendricks, Rama Kondru, Yan Lou, Timothy D Owens, Michael Soth, Hanbiao Yang; Pyrrolopyrazine kinase inhibitors; US Patent 7,902,197. *Georgette Castanedo, Bryan Chan, David Michael Goldstein, Rama Kondru, Matthew C Lucas, Wylie Solang Palmer, Stephen Price, Brian Safina, Pascal Pierre Alexandre Savy, Eileen Mary Seward, Daniel P Sutherlin, Zachary Kevin Sweeney; Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use; WO Patent WO2010138589. *Nolan James Dewdney, Ronald Charles Hawley, Rama Kondru, Yingjie Lai, Yan Lou; Inhibitors of bruton's tyrosine kinase; WO Patent WO2010122038. *Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loc, Yan Lou, Joel McIntosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Inhibitors of Bruton's tyrosine kinase; US Patent 7,683,064. *Rama Kondru, Yan Lou, Eric Brian Sjogren, Michael Soth; Novel phenylimidazopyrazines; WO Patent WO2010006970. *Joe Timothy Bamberg, Mark Bartlett, Du Bois, Daisy Joe, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama Kondru, Remy Lemoine, Yan Lou, Timothy D Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee; Pyrrolopyrazine kinase inhibitors; WO Patent WO2009106442. *Nolan James Dewdney, Joshua Kennedy-Smith, Rama Kondru, Bradley E Loe, Yan Lou, Joel Mcintosh, Timothy D Owens, Michael Soth, Zachary Kevin Sweeney, Joshua Paul Gergely Taygerly; Novel pyridinones and pyridazinones; WO Patent WO2009098144. *Nolan James Dewdney, Tobias Gabriel, Rama Kondru, Yan Lou, Michael Soth; Novel kinase inhibitors; WO Patent WO2009053269. *Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; Novel antagonist for CCR2. U.S. Patent 6,727,275. *Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintingh, Laurent Knerr; Rama Kondru; Eric Schwartz; Hai Xiao Zhai; CCR2 : Pyrrolidinone derivatives. WO2003030897. PUBLICATIONS *A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds. J A DiMasi, J C Hermann, K Twyman, Rama Kondru, S Stergiopoulos, K A Getz, W Rackoff. Clinical Pharmacology and Therapeutics 2015, 98 (5): 506-13. *Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis. Yan Lou, Xiaochun Han, Andreas Kuglstatter, Rama Kondru, Zachary K Sweeney, Michael Soth, Joel McIntosh, Renee Litman, Judy Suh, Buelent Kocer, Dana Davis, Jaehyeon Park, Sandra Frauchiger,Nolan Dewdney, Hasim Zecic, Joshua P Taygerly, Keshab Sarma, Junbae Hong, Ronald J Hill, Tobias Gabriel, David M Goldstein, Timothy D Owens. J Med Chem 2015 Jan 16;58(1):512- *A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands. David C Swinney, Paul Beavis, Kai-Ting Chuang, Yue Zheng, Ina Lee, Peter Gee, Jerome Deval, David M Rotstein,Marianna Dioszegi, Palani Ravendran, Jun Zhang, Surya Sankuratri, Rama Kondru, Georges Vauquelin. Br J Pharmacol 2014 Jul;171(14):3364-75. *Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold. Yan Lou, Zachary K Sweeney, Andreas Kuglstatter, Dana Davis, David M Goldstein, Xiaochun Han,Junbae Hong, Buelent Kocer, Rama Kondru, Renee Litman, Joel McIntosh, Keshab Sarma, Judy Suh,Joshua Taygerly, Timothy D Owens. Bioorg Med Chem Lett 2015 Jan 20;25(2):367-71.
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School Attended

  • University of Pittsburgh Medical Center
  • University of Pittsburgh Peter Wipf University of Pittsburgh Prof. David Beratan Duke University
  • Indian Institute of Technology (I. I. T

Job Titles Held:

  • Global Head, Data Sciences and Advanced Analytics, Pharma IT
  • Associate Director and Head
  • Project leader Global Chemical Biology Initiative
  • Principal Research Scientist
  • Research Scientist-II
  • Principal Scientist
  • Senior Scientist-III
  • Senior Scientist-II
  • Senior Research Scientist
  • Adjunct Professor

Degrees

  • Post-doctoral fellow :
    Ph.D : Biophysics and Quantum Chemistry
    B.S and M.S :

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