I have extensive experience in drug design and development. I hold a patent and published several papers for the development of novel cell-permeable RNA-targeted antiviral aminoglycosides. I originally discovered cytochrome c - mediated mechanisms of action of mitochondria-protective aromatic-cationic tetrapeptides, Elamipretide (Bendavia or SS-31), and I was fully involved in the preclinical phase of this compound and the planning of Phase I and initial Phase II clinical trials. I actively participated in the development and Phases I, II, III, and IV (marketing phase) of a metabolic-bypass therapy platform to apply mitochondrial metabolism concepts for optimization of the synthesis of inhibitory neurotransmitters. This concept, through NeuroEssence, LLC., is presently used as nutraceutical formulation to help children with autism.
5 published publications of the mechanism of action of SS-31 (Bendavia/Elamipretide) and SS-20, as novel mitochondria-targeted compounds
Discovery and Development of aminoglycoside-based antivirals against Dengue virus and HCV
Interaction of tetrapetides, SS-31 and SS-01 with IRES of HCV RNA. Development of in vitro and ex vivo models
Role of tRNA-like domain of IRES of HCV in a regulation of viral replication.
Role of ATP metabolism in platelet reactivity and thrombosis
Publications on the Mechanisms of 5S-RNA and tRNA processing
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